Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 pot

... 2005 FEBS Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 Po-ki Ho 1,2,3 , Anissa M. Jabbour 1,2,3 , Paul G. Ekert 1,4,5 and Christine J. ... (or empty vectors) were transformed into yeast and transformants spotted onto inducing medium to visualize their impact on yeast growth. Caspase-2 can a...

Ngày tải lên: 23/03/2014, 13:20

... Bacitracin is not a specific inhibitor of protein disulfide isomerase Anna-Riikka Karala and Lloyd W. Ruddock Biocenter Oulu and Department of Biochemistry, University of Oulu, Finland Introduction Protein ... PDI inhibitors and specific antibodies have often been used to discover the function of PDI-like proteins, especially outside the ER. Bacitracin is a commonly used...

Ngày tải lên: 16/02/2014, 14:20

... similar to the corresponding preimmune yolk and was not used for further immunohistochemical studies (data not shown). Immunohistochemistry and confocal laser scanning microscopy were used to determine ... endogenous MPP5 can be detected as 70 kDa band in cell lysates, but upon coimmunoprecipitation with MPP3 it is visible as double band of 70 and 80 kDa, due to enrichment...

Ngày tải lên: 16/03/2014, 13:20

... empty vector, DAT ⁄ P25a and DAT ⁄ a-syn to obtain equal concentrations of vector DNA were incubated in the absence and presence of 0.5 m M DA for 24 h and subjected to analysis of viability by the ... analysis of DA and serotonin uptake, respectively. 3 [H]-DA was used to determine V max curves for DAT and NET, as 3 [H]-DA can also be used by NET, and 3 [H]-se...

Ngày tải lên: 14/02/2014, 21:20

... N 1 and N 2 are the sets of nodes in trees T 1 and T 2 , respectively, and () i subtree In is a function that is 1 iff the subtree i occurs with root at node n and zero otherwise, and ... 1 ()nc n is the child number of 1 n , ch(n,j) is the j th child of node n and λ (0< λ <1) is the de- cay factor in order to make the kernel value less variable...

Ngày tải lên: 20/02/2014, 12:20

... lists are then sent off to the dictionary and go through several rounds of careful analysis before actually being submitted to the dictionary. The ratio of proposed can- didates to good candidates ... as the precision of Xtract is raised from 40% to 80% with a recall of 94%. By combining statistical techniques with a sophis- ticated robust parser we have been abl...

Ngày tải lên: 08/03/2014, 07:20

... RNA, as shown by the failure of a control RNA (i.e. the antisense strand to BcBL1) to bind to any concentration of PyrR tested (Fig. 2A). Binding of PyrR to BcBL2 and BcBL3 in standard binding ... modulators of PyrR binding to pyr attenua- tor region RNA, and hence the primary regulators of pyrimidine biosynthesis. Uridine nucleotide stimulation of RNA binding is...

Ngày tải lên: 16/03/2014, 06:20

... that of DHFR. The resulting mutant fusion proteins can again be expressed in E. coli, and TMP resistance can be monitored. The genes of mutants that confer increased TMP resistance are isolated and ... ligand to a residue that is unli- kely to bind metal. The G270V residue is located next to a metal-binding residue ) this mutation is likely to cause a conformationa...

Ngày tải lên: 23/03/2014, 07:20

... to be recessive. This is handled by establishing in cue space a central location and within-cluster variance for each prime. The training sample needed for this consists of segments in which ... transforms (FFTs) of speech signals in terms of total amplitude or energy distribution ED across low, middle and high frequency parts of the vocal range and the angular freq...

Ngày tải lên: 31/03/2014, 04:20

... related and have no rele- vance to in vivo function of the protein and even less to amyloid fibrillation. As for the function [10,11,18], this is open to more research. The protein decreases apoptosis ... myoclonus epilepsy of the Unverricht–Lundborg type. In studies of CSTB-deficient mice, lack of this inhibitor was found to be associated with signs of cerebellar gr...

Ngày tải lên: 19/02/2014, 06:20