Báo cáo khoa học: Kinetic analysis of zymogen autoactivation in the presence of a reversible inhibitor pptx
Báo cáo khoa học: Kinetic analysis of zymogen autoactivation in the presence of a reversible inhibitor pptx
... Kinetic analysis of zymogen autoactivation in the presence of a reversible inhibitor Wei-Ning Wang, Xian-Ming Pan and Zhi-Xin WangNational Laboratory of Biomacromolecules, Institute of Biophysics, ... the autoactivation of zymogens, which is a particular case of the activation of zymogens. As the autocatalytic activation of zymogens plays a key role in the regulation of manyintegrated metabolic ... doi:10.1111/j.1432-1033.2004.04416.xTheoretical analysis In the case of the autocatalytic reactions, the zymogen serves as a substrate in reactions. The general mechanism of the autocatalytic reaction o f an enzyme in the presence of...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... in various organ systems. Even in organismslacking a brain, such as Caenorhabditis elegans, the nervous system plays a key role in maintaining energybalance [1–4]. In more advanced, mammalian ... intracerebroventricular administration of fatty acid synthase (FAS) inhibitors causes a dra-matic decrease in food intake and body weight, con-comitant with an increase in the level of its substrate,malonyl-CoA ... increase in malonyl-CoA promotes a decrease in neuropeptide Y and agouti related peptide in hypo-thalamic malonyl-CoA while promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... the minimal transcrip-tionally active fragment and are required simulta-neously to maintain transcription. The PHF3 protein was recovered in initial analysesand also contains a TFS2M domain ... protein domain architectures thatshare a canonical bipartite nuclear localization signaland a PHD domain (Zn finger) at the N-terminalregion. The long isoform also contains transcription fac-tor ... analyses of all splice variants link DIDO1 toother distantly related protein families involved in DNA binding and chromatin stability. Moreover,additional experimental data place the DIDO proteinin...
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Tài liệu Báo cáo khoa học: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters pdf
... recombinantenzymes free of albumin and any other AAAs. It wasfound that there was no fundamental difference in the mechanisms of inhibition and activation for either the AAA or esterase activities ... hydrolases that catalyse the deacylation of N-acyl arylamines [20,21]. SeveralAAAs have been identified in mammalian tissues[22,23]. Certain acryl acylamidases are identical tocarboxylesterases ... of retinal melatonin into 5-methoxytryptamine is cataly-sed by an eye AAA [27]. However, no clear physiologi-cal function has yet been ascribed to most mammalianAAAs. At a minimum, AAAs are...
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Tài liệu Báo cáo khoa học: An engineered disulfide bridge mimics the effect of calcium to protect neutral protease against local unfolding docx
... measure-ment of the remaining activity towards casein or the synthetic substrate 2-aminobenzoyl-Ala-Gly-Leu-Ala-4-nitrobenzylamide (Abz-AGLA-Nba), as described in the Experimental procedures. Inactivation ... stearothermophilus and itsvariants have been based on thermoinactivation meas-urements assuming that inactivation is determinedby autoproteolysis as a consequence of rate-limitingunfolding. A separate kinetic ... for a kinetic analysis of unfolding and autoproteolysis of G8C ⁄ N60C and pWT. In contrast to previous studieson the kinetics of thermoinactivation [13,24], thisapproach allows quantification of...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... depending on the input, interconnections to other information, and an automatic activity decay scheme. In addition, the decay scheme is based on the state of the information, whether it has reached ... French Because of the parallel activation of all meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active ... associates, within grammar, and as a pragmatic interpretation. Each piece of information is a thresholding device with memory. It has an activity value, initially at a resting state, that is modified...
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Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx
... SoaplabSoaplab (Senger et al., 2003)2allows a WSP todeploy a command line tool as a WS just by writ-ing a metadata file that describes the parameters of the tool. Soaplab takes care of the ... translators when they starttranslating documents for a new domain. As atthat early stage they still do not have any content in their TM, having the automatically acquiredTM can be helpful in ... registry.First, we use a domain-focused bilingualcrawler13 in order to acquire the data. Given a pair of languages, a set of web domains and a set of seed terms that define the target domain for these13http://registry.elda.org/services/127languages,...
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Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf
... disturbanceFig. 6. Diagram of the surface of duck d-crystallin (1AUWÆpdb). (A) Each subunit of the tetrameric d-crystallin shows a surface with several convexand concave areas as indicated by a , ... refraction [1–3]. Thermodynamic stabilityfor crystallins is essential in maintaining lens transparency[4]. Determining the mechanism of folding and assembly of these proteins is important for ... performed according to the methods described previously [15]. The endogenousargininosuccinate lyase activity of d2-crystallin was moni-tored as a function of the appearance of fumarate at240...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... the absence of a B chain [152]. The degrada-tion of ricin A chain is brefeldin A- insensitive and isinhibited by the proteasome inhibitor clasto-lactacystinb-lactone, resulting in the accumulation ... of ricin A chains. These stabilized ricin A chains are partlydeglycosylated by a peptide–N-glycanase-like activity.Taken together, these results indicate that the ricin A chain behaves as a ... a catalytic A chain and a Bchain linked by a single disulfide bond. The ER-tar-geted A chain is degraded by a pathway that closelyresembles ERAD when expressed in tobacco proto-plasts in the...
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Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf
... Castilla, Alejandra Duarte, Paula Maloberti,Cristina Paz and Ernesto J. Podesta´Department of Biochemistry, School of Medicine, University of Buenos Aires, ArgentinaArachidonic acid (AA) is a fatty ... cells as anexperimental system, we described an alternativereleasing mechanism for AA as a mediator of hormoneaction with the participation of an acyl-CoA synthe-tase (ACS4) and a mitochondrial ... using 300 lm AA in the pres-ence of albumin. These different results can beexplained by the fact that protein binding can increase the overall concentration of fatty acids present in anaqueous...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ