Báo cáo khoa học: The N-linked oligosaccharides of aminopeptidase N from Manduca sexta pptx

... GlcNAc antennae and the distal GlcNAc of th e chitobiose un it in N- glycans. Furthermore, the major N- glycan components on APN1 carry antennae linked to the 6-arm of core mannose. This is in accord ... character- ization of the N- glycans on the major APN1 protein, as inspection of their amino acid sequences revealed seven consensus sequences for N- glycosylation in AP...

Ngày tải lên: 23/03/2014, 13:20

... 2559 Structure of Anx(Gh1) in comparison with Anx24(Ca32) and AnxA5 The three-dimensional crystal structure of annexin G h1 contains the typical annexin fold, well known from the studies of other members of ... raised the question of how this might be accomplished by plant annexins. As mentioned earlier, the endonexin sequence as a constituent of canonical calcium bind...

Ngày tải lên: 17/03/2014, 03:20

... predicted gen- eral feature of the mechanism is the devel- opment of a strong hydrogen bond between the incoming nucleophile and the leaving group in the transition state of the reaction. The phosphate ... recorded in the absence and presence of rescue reagent concentra- tions in the range 10–200 mm. Guanidine and propar- gylamine did not exhibit a significant effect...

Ngày tải lên: 30/03/2014, 04:20

... space-filling mode. The positions of the N- terminal and C-terminal amino acid residues of the model, the position of the flexible loop region, which is omitted in the final model, and the position of the ... activation of KlPDC involves only a part of the processes in ScPDC, namely, binding of the regulatory substrate(s) in the cleft between the R and PP d...

Ngày tải lên: 30/03/2014, 10:20

... resolution and a bandwidth of 2 nm. The concentration was 1.25 l M for PHO. The spectrum was analyzed with the CDNN deconvolution program [32]. Construction and screening of the genomic library The ... structure has been elucidated [19,20], allowed the identification of the consen- sus sequences for the coordination of a dinuclear oxo-iron centre. The presence of th...

Ngày tải lên: 31/03/2014, 01:20

... finding' was any old finding not expected by the attending physician. If an important finding (as mentioned in Table 1) was found, then we determined whether any action was taken because of the ... finding' was any old finding predicted by the attending physician; a 'new unex- pected finding' was any new finding not predicted by the attending physician; and an &a...

Ngày tải lên: 25/10/2012, 10:39

... [3]. Interest in control mechanisms of cyclin B1 and cyclin B2 cell cycle-dependent transcription began early [3,30–33]. When investigating the regulation of human cyclin B1 transcription, a potential ... upregulation would indicate a function of Lin-9 in repression. This indicates that Lin-9 is involved in the activation of these genes in cycling cells. In summary, it has been sh...

Ngày tải lên: 16/02/2014, 09:20

... against the N- terminal end of helix 4 of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix 7 of the NTD of the neigh- boring ... domains in each hexamer, the dimerization interface between CTD domains belonging to neighboring hexamers, and another interface between CTD and NTD domain...

Ngày tải lên: 18/02/2014, 06:20

... the assembly-competent mutants E187A and N1 83A: the conformations of the two assembly-incompetent mutants (Y169A and L211A) in the absence of CAI are the same as the structures of any mutant when complexed to the ... CTD-binding organic compound also establishes hydrophobic contacts with regions involved in the interface between the NTD and CTD. These results open ne...

Ngày tải lên: 18/02/2014, 06:20

... 1A), and increas- ing concentrations of proBMP-2. A proBMP-2 concen- tration-dependent inhibition of the BMP-2-induced AP activity was observed (Fig. 1C). The possibility of con- tamination of the ... by noggin. In addition to the potential physiological implica- tions of our findings, the interaction of proBMP-2 with BMPR-IA and noggin allows indirect conclusions about...

Ngày tải lên: 18/02/2014, 06:20