Báo cáo khoa học: Donor substrate regulation of transketolase pptx

... enhancement of thiamin diphosphate’s affinity to apotransketolase in the presence of donor substrate is probably one of the mechanisms underlying the sub- strate-affected transketolase regulation ... Holoenzyme of transketolase (holoTK) i n the absence of substrate after subtraction of the spectra of the transketolase apoenz yme (apoTK) and thiamin diphosphate (ThDP);...

Ngày tải lên: 23/03/2014, 13:20

... of their target genes. Indeed, several examples of feedback regulation that involve miRNAs have been reported. Below, we attempt to summarize our recent understanding of feedback regulation of ... Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation Table 1. miRNAs involved in the fe...

Ngày tải lên: 14/02/2014, 19:20

... ED, Blackwell HE, Moazed D & Schreiber SL (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-depen- dent deacetylases by phenotypic screening. J Biol Chem 276, ... Identification of a small molecule inhi- bitor of Sir2p. Proc Natl Acad Sci USA 98, 15113– 15118. 53 Posakony J, Hirao M, Stevens S, Simon JA & Bedalov A (2004) Inhibitors...

Ngày tải lên: 20/02/2014, 01:20

... mechanism of regulation of both domains involves a common iron dependent process [74,75,79]. Regulation of HIFa subunits by oxygen-dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... the hydroxylation of their substrates (Fig. 2), the binding of NO to the catalytic core of PHD/HPHs and FIH-1 may block enzymatic activity, explaining the reported positive eff...

Ngày tải lên: 20/02/2014, 23:20

... subsequent degra- dation of the receptor in transfected human embryonic kidney cells [50]. Direct regulation of the EGFR by CaM The direct regulation of the EGFR upon binding of the Ca 2+ ⁄ CaM complex ... C-terminal lobe of the kinase domain of one of the monomers forming the dimeric receptor interacts with the N-terminal lobe of the apposed monomer [19,47,84]. Of relev...

Ngày tải lên: 06/03/2014, 09:22

... binding of U2AF. The lower panel shows that most of the HIV-1 3¢ss deviate from the consensus because of their low content of pyrimidine nucleotides. A B Fig. 4. Positive and negative regulation of ... further understanding of infection, spread and dissemination through splicing regulation. Such stud- ies coupled with the testing of splicing inhibitors should help the develop...

Ngày tải lên: 06/03/2014, 09:22

... out using 20 lg of AraL with varying concentrations of substrates. Kinetic parameters were determined using the enzyme kinetics software graphpad prism, version 5.03 (GraphPad Software Inc., San ... On the basis of substrate specificity and gene context within the arabinose metabolic operon, a putative physiological role of AraL in the detoxification of accidental accumulation of...

Ngày tải lên: 14/03/2014, 23:20

... Nagao et al. Function and regulation of ABCA1 FEBS Journal 278 (2011) 3190–3203 ª 2011 The Authors Journal compilation ª 2011 FEBS 3203 MINIREVIEW Function and regulation of ABCA1 – membrane meso-domain ... of both PC and free cholesterol. Indeed, ABCA1, expressed in cultured cells, mediates the secretion of both types of lipids when lipid-free apolipoprotein A-I (apoA-I), an Ta...

Ngày tải lên: 22/03/2014, 15:21

... expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and inducing that of matrix metalloproteinase-2 (MMP-2) [7,16], which in turn degrades MMP-1 cleaved collagen I [17]. Regulation of ... opposing effects of ET-1 on collagen I synthesis and breakdown clearly indicate an important role for ET-1 in the dynamic regulation of ECM and its dysregulation in disease...

Ngày tải lên: 23/03/2014, 11:20

... that of the AC isoform Rv1264 (Fig. 1A). The C-terminal class IIIc CHD of 177 amino acids shares 29% identity with that of Rv1264 (41% similarity; for alignments see [20]). The N-terminus of Rv2212 ... dependent on the presence of the N-terminal domain of Rv2212. Because the high variability in the AC activity of Rv2212 was reflected in a large variability of the extent of st...

Ngày tải lên: 30/03/2014, 10:20