Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx

... 2004 The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations Guizhi Wu, Silvia Bohn and Gerhart U. Ryffel Institut ... potential of the POU S and POU H domains of HNF1b. Domains of HNF1b involved in nephrogenesis The simplicity 14 of the Xenopus system allow...

Ngày tải lên: 23/03/2014, 13:20

... transcription factors in the regulation of prostaglandin G ⁄ H synthase 2 expression by interleukin-1 in osteoblastic MC3T3–E1 cells. J Bone Miner Res 15, 1138–1146. 6 Iniguez MA, Martinez-Martinez S, ... Manning C, Akbarali Y et al. (2003) Responses to the proinflammatory cyto- kines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and...

Ngày tải lên: 19/02/2014, 17:20

... of the Bcl-2 family, and the forkhead transcription factor FKHR [25], a proapoptotic tran- scription factor, thereby inhibiting them, the PtdIns3- K ⁄ Akt signaling pathway has emerged as the ... shown that the bcl-X gene has consensus sequences for the binding of several transcription factors, including NF-jB, AP1, and GATA-1 [29,30]. In response to a suitable...

Ngày tải lên: 19/02/2014, 06:20

... E2F4 ⁄ 5 and DP1 ⁄ 2 and a module containing the MuvB proteins Lin-37, Lin-52, Lin-54 and chromatin- associated Lin-9 and Lin-53 ⁄ RBBP4 ⁄ RbAp48. Furthermore, A-Myb and B-Myb were present in immunoprecipitations ... [87]. However, the limitation of ChIP analyses is that the exact binding location is not identified in the experi- ments. Therefore, it is not clear whether...

Ngày tải lên: 16/02/2014, 09:20

... activation domain during evolution. Domains of mouse HSF3 were swapped with the corresponding domains of chicken HSF3, and the chimeras possessing the chicken HSF3 activation domain induced the expression ... alanine-rich sequence and the DNA-binding domain is sufficient to cause the func- tional difference between the two orthologues [28]. As chicken HSF1 can bind to th...

Ngày tải lên: 18/02/2014, 04:20

... weak, and both N-terminal and C-terminal flanking sequences enhance the nuclear targeting of EGFP. Finally, several mutations in the HMG1 domain increased the mitochondrial targeting of the EGFP ... fusion proteins, implying involvement of these residues in nuclear targeting. Interestingly, mutations in three invariant residues (P66, W88, and K96) resulted in a significa...

Ngày tải lên: 07/03/2014, 05:20

... manuscript revision. JK was involved in the design and statistical analysis of the study. MS conceived and coordinated the study and was involved in the interpretation of the data and manuscript revi- sion. ... involved in drafting the manuscript. MG participated in analysis and interpretation of the data and in drafting the manuscript. PS, JS and...

Ngày tải lên: 25/10/2012, 10:39

... attributed to the physical prox- imity of the enzymes in the mini-cellulosomes and to cellulose targeting of the complexes via the CBM of the mini-scaffoldin [21]. The most active mini-cellulo- some ... genes were found to be gathered in a large operon called the cip-cel cluster, beginning with the gene encoding the scaffolding pro- tein named cellulosome-integrating...

Ngày tải lên: 18/02/2014, 08:20

... a protein with covalently attached flavin, synthesized only in bacteria grown in the presence of nicotine The DNA carrying the sarcosine dehydrogenase-like ORF63, corresponding to a protein of ... occurrence and has been described in detail for different bacteria [31,33]. The similarity of the C-terminal domain of MABO to other proteins of the sarcosine dehydrogen ase an...

Ngày tải lên: 19/02/2014, 16:20

... many other acetylated proteins, removal of the initiator methionine residue and acetylation of the glutamic acid residue is important in regulating the interaction between actin and myosin in the ... heterogeneous N-terminal peptide. Fig. 4A shows the tandem mass spec- trum of the N-terminal peptide as reported in the sequence database: the N-terminal methionine resi...

Ngày tải lên: 20/02/2014, 23:20