Báo cáo khoa học: NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical b-toxin sequence but with a-like physiological activity doc

... a novel peptide from the Mexican scorpion Centruroides noxius with a typical b-toxin sequence but with a- like physiological activity Federico del Rı ´ o-Portilla 1 , Elizabeth Herna ´ ndez-Marı ´ n 1 , ... 2, using the CLUSTAL X program, shows a clear cut separation of all the b Na-ScTxs from all the a Na-ScTxs. The a Na-ScTxs have ident...

Ngày tải lên: 23/03/2014, 12:20

... signal of the preceding amino acid, correlating the amide HN and the Ca signals, correlating the amide HN and the Ca signal of the preceding amino acid, correlating the amide NH with the Ca and ... here the high-resolution NMR structure of the human C-domain in solution, and present data on its dynamics. On the basis of the structural data, we have perfo...

Ngày tải lên: 06/03/2014, 11:20

... by the Natural Sciences and Engineering Research Council of Canada, the Alberta Heritage Foundation for Medical Research, CanBiocin Ltd (Edmonton, AB), and the Canada Research Chair in Bioorganic ... structural basis of the inhibition of the antimicrobial activity of CbnB2 by the leader and to assist future analysis of the interaction of preCbnB2 with its ABC tra...

Ngày tải lên: 07/03/2014, 15:20

... a helicase sep- arates the double-stranded DNA into single strands, and replication of the leading strand and synthesis of the Okazaki fragments is initiated by RNA primers made by the specialized ... Otting Research School of Chemistry, Australian National University, Canberra, Australia All organisms replicate DNA by copying one strand (the leading strand) in a continuou...

Ngày tải lên: 16/03/2014, 12:20

... introduction of paramagnetic probes into the interior of the micelle or the aqueous buffer. Qualitative analysis of secondary chemical shift and paramagnetic relaxation enhancement data in conjunction with dynamic ... 0.088 Ramachandran analysis Most favoured 58% Additionally allowed 31% Generously allowed 6% Disallowed 5% a The sum of all NOE violations larger than 0.015...

Ngày tải lên: 18/02/2014, 06:20

... Significantly, this structural feature of NOXtp is highly similar to that of valosine-containing protein-like ATPase from Th. acidophilum, an archaeal member of the AAA family (ATPases associated with a ... Multivariate statistical analysis of NOXtp. (a) The average (AV) of 939 translationally, but not rotationally, aligned particles with end-on orientation and the 1...

Ngày tải lên: 07/03/2014, 04:20

... The final absorbance was estima- ted from e ach curve; the absorbance at each time point was subtracted from that value. A plot of the natural logarithm of these differences vs. time was linear ... PpiA, in a structure- base d sequence alignment. All three structures show an rmsd of approxi- mately 1.6 A ˚ from that of Mt PpiA, when the C a atoms are compared u...

Ngày tải lên: 16/03/2014, 18:20

... X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b- D-galactopyranoside Sanjeewani Sooriyaarachchi 1 , Wimal Ubhayasekera 1 , ... (hereafter referred to as GGal) is found naturally as the polar head group of plant glycolipids. An estimated 16.6% of the total lipids in runner bean leaves repres...

Ngày tải lên: 23/03/2014, 04:21

... group and within a van der Waals distance of a methine carbon atom (CHA) of the porphyrin ring. In consequence, Gln57 is capable of tuning the redox potential of the heme group [7,8]. An insert of ... towards the surface of the protein and contribute to the overall negative surface potential. The major negative patch, however, is created mainly by the side chai...

Ngày tải lên: 23/03/2014, 05:22

... Analysis of N-terminal amino acid sequencing The N-terminal amino acid sequence of recombinant TTRs were determined using an automatic Edman degradation at La Trobe University, Australia, and ... was faster than that of albu- min, which is a typical characteristic of TTR of most vertebrates found in nature [21]. Native TTR in plasma exists in the tetrameric form. The mol...

Ngày tải lên: 23/03/2014, 10:21