Báo cáo khoa học: Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control doc

... Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control Margareta ... the insulin receptor in caveolae. In type 2 diabetes the tissues respond poorly to insulin, exhibiting insulin resistance that...

Ngày tải lên: 23/03/2014, 12:20

... management of data acquisition, ability to export graphics and documents from a variety of formats, format plots and text objects, and the ability to adjust the specifications and instrument settings for ... has provided fascinating insights to several factors that contri- bute to maintaining this delicate balance. Several proteins are now known to exist, some that bind...

Ngày tải lên: 17/03/2014, 09:20

... four semantic categories and the role of it is formalized into five modality functions. Based on these formalizations, information and constraints to be applied to the modality analysis procedure ... the meaning of a sentence consists of both proposition and rnodality, TM analysis of modality is as indispensable as that of proposition for natural language unders...

Ngày tải lên: 24/03/2014, 01:21

... Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity label- ling: additional evidence for a three-loop model of ... receptor. Abbreviations 5-HT 3A receptor, serotonin type 3 A receptor; a-BgTx, alpha-bungarotoxin; ACh, acetylcholine; AChBP, acetylcholine binding protein; dTC, d-tubocurar...

Ngày tải lên: 19/02/2014, 07:20

... by binding to cytosolic Ca-binding sites after flowing through the conducting pore. As Gd 3+ can bind to the Ca 2+ -binding sites of different membrane proteins we investigated the effect of this ... muscle. In the [ 3 H]ryanodine binding assay, 5 lm Gd 3+ increased the K d of the [ 3 H]ry- anodine binding of the vesicles from 33.8 nm to 45.6 nm while B max , refer- ring to t...

Ngày tải lên: 19/02/2014, 16:20

... extracellular ANP- binding domain (ECD), a transmembrane domain, and an intracellular domain consisting of an ATP-binding regulatory domain and a GCase catalytic domain [8]. ANP binding to the ECD stimulates ... change in the interdomain distance. (B) Schematic presentation of the movement of the juxta- membrane domains in response to ANP binding. Looking down- wards toward...

Ngày tải lên: 07/03/2014, 03:20

... of the TCR complex c, d, e and f chains, as well as in other immunoreceptors including the B-cell receptor [3] and several Fc receptors [4,5]. Doubly phosphorylated ITAMs form binding sites for pairs ... domain in Lck which binds to phosphotyrosines in an ITAM context with high affinity [26]. On binding of the SH2 domain of Lck to a phosphorylated tyrosine in TCRf, an...

Ngày tải lên: 08/03/2014, 02:20

... (1999) Presence of a soluble inhibitor of thyroid iodination in primary cultures of thyroid cells. Eur. J. Endocrinol. 141, 55–60. 2. Larner, J. (1983) Mediators of postreceptor action of insulin. Am. J. ... propose that the insulin mediator, as inhibitor of TPO activity, is responsible for the decrease of thyroid hormone biosynthesis in primary cultures in the pr...

Ngày tải lên: 30/03/2014, 14:20

... incorpo- rated CPOE and a moderate level of CDSS (Centricity Critical Care Clinisoft, GE Healthcare Europe, Helsinki, Finland), with full connections to monitors, ventilators, syringe pumps and also ... correspond- ing drug dose was shown, together with the different dosing schemes for renal insufficient patients (according to creatinine clearance, intermittent or continuous hemod...

Ngày tải lên: 25/10/2012, 10:39

... with F-actin via b-catenin and a-catenin; b-catenin binds to cadherin and a-catenin, which in turn interacts with F-actin (Fig. 3A) [24]. Thus b-catenin plays a pivotal role in the regulation of cell–cell ... synchronous increases in intracellular [Ca 2+ ], as described below. Synchronous increases in intracellular [Ca 2+ ] and disassembly of cadherin–catenin complexes The...

Ngày tải lên: 16/02/2014, 09:20