Báo cáo khoa học: The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis pptx

... principle demonstrating the ability of the HAMP domain region to regulate AC activity. The effect of the HAMP domain on the CHD of Rv1319cwas much less pronounced, supporting the earlier notion of a ... investigated the HAMP domain function in the context of mycobacterial class IIIb ACs. The isolated CHDs of all four isoforms were puriﬁed and had AC activityin vitro. Inclusion of the N-terminal HAMP- regionenhanced ... in the effects of the HAMP domains reside in particular features of the respective ensemble or arethey intrinsic properties of the respective HAMP domains? To answer this question we swapped the...

Tài liệu Báo cáo khoa học: "The Effect of Pitch Accenting on Pronoun Referent Resolution" ppt

... also consider the way intonation affects the interpretation of a sentence, especially the cases in which it alters the predictions of centering theories. I investigate this via a phenomenon that, ... tone and an optional leading or trailing tone. The form of the accent L, H, L+H or H+L informs about the operation that would relate the salient item to the mutual beliefs 1 of the conversants; ... effect is attentional, on the order of items in Cf; (2) the obligation to accent a pronominal for attentional r~asons depends on the variance between what the text predicts and what the speaker...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... concentrations of Arg-HClin the absence of the chaperone precluded analysis of the effect of this concentration on the protectiveability of aB-crystallin.Reduction-induced aggregation of the insulin ... aggregation. We report that the effect of these additives on the chaperone action of aB-crys-tallin is dependent on the target protein used, andtherefore the results highlight the need to assess the activity ... aB-crystallin (i.e. the effect of the additive on the aggregation of the target protein is inde-pendent and different from that of the chaperone). The standard errors associated with this theoretical...

Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

... deviation (RMSD) from the Ca atoms of the wild-type crystal structure [11] of 0.33 A˚. The electron density in the area local to the substitution is shown in Fig. 4. The positions of catalytic ... hydrogen bonds to be formed between the base G4and the sidechain of Asn122. In the second model(Fig. 1B) the structure of the hexanucelotide is, on the whole, unchanged and the majority of the interactions ... which the principal diﬀerence lies in the conformation of the second ÔGÕ in the target GAGA motifin the 28S rRNA substrate. In one model, the sidechain of Asn122 is proposed to make interactions...

Báo cáo khoa học: The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding ppt

... interactions (Fig. 4D). Effect of the M100K mutation on the stability of the native state The effect on protein stability upon introduction of aLys ligand to the heme-iron has been assessed for the M100K ... postulated to arise from the deprotonation of an ionizable group (the ‘trigger’) the nature of which is as yet unknown. For the M100Kvariant it seems likely that the deprotonation of the trigger is ... structures, one of the ferric wild type (wt) and two of the ferric M100Kvariant. The latter conﬁrm Lys–heme coordination.Also the effect Lys–heme coordination has on the unfolding of the M100K...

Báo cáo khoa học: The effect of heme on the conformational stability of micro-myoglobin doc

... side-chains of Arg45 and Lys96 (Fig. 8). These interactions conceiv-ably also contribute to the conformational stability of holo-lMb. Consistently, they are maintained over the 1.5 ns of the simulation ... in the ﬁrst0.5 ns of MD simulation, triggering the unfolding of helix E and the subsequent global unfolding of the structure. In holo-lMb, the shielding effect of the heme and the engagement of ... atoms in the center of aprotoporphyrin ring. The metal ion can form twoadditional coordinative bonds on either side of the heme plane, termed the ﬁfth and sixth coordinationpositions, which...

Báo cáo khoa học: "The Effect of Translation Quality in MT-Based Cross-Language Information Retrieval" pptx

... rather than words. The other factor is the translation resources com-prised in the MT system. Our observation showed that the size of the dictionary has a stronger effect on retrieval effectiveness ... on dictionary-based degradation comparable to the results on rule-based degrada-tion, we degrade the dictionary so that the varia-tion interval on translation quality is similar to that of ... of translation quality of MT system on CLIR performance? The possible reason might be the problem on how to control the translation quality of the MT system as what has been done to bi-lingual...

Báo cáo khoa học: "The effect of domain and text type on text prediction quality" pptx

... leave-one-out setting (359 times training on 358 questions and evaluating on the re-maining questions). The prospective application of the third series of experiments is the development of a ... next block of charac-ters (the ‘predictive unit’). If the user gets correctsuggestions for continuation of the text then the number of keystrokes needed to type the text isreduced. The unit ... togather real user data once we have a ﬁrst version of the user interface running online. For develop-ing the text prediction algorithm that is behind the initial version of the application,...

Báo cáo khoa học: The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the Vibrio cholerae ToxR protein pot

... recogni-tion, the ionic strength of the medium would beexpected to have an effect on the binding [43]. Tostudy the effect of ionic strength on the conformation of ToxRp in the presence of ZnO ... knowledge of the mechanism(s) of association and interaction of proteins with the particlesurface and the consequent effect on the structure of the protein. Towards achieving this goal we studied the ... thermodynamicparameters of binding one can speculate on the nature of the interaction between ToxRp and ZnO NPs, and the consequent effect on protein conformation. The NP-treated protein is...

Báo cáo khoa học: The effect of pH on the initial rate kinetics of the dimeric biliverdin-IXa reductase from the cyanobacterium Synechocystis PCC6803 pptx

... reciprocal of the apparent Vmaxwas plotted against the concentration of inhibitory product and the inhibition constant for the inter-cept effect (Kii) was determined from the intersection on the inhibitor ... [5].Questions on the possible function of BVR-A incyanobacteria parallel a major re-evaluation of the function of BVR-A in mammals. Once considered toplay a role solely in the elimination of excess ... and the variation of initial rate with the concen-tration of the second substrate is then used to estimatekcatand the Kmfor the variable substrate. However, the assumption that a concentration...

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