Báo cáo khoa học: The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis pptx

... principle demonstrating the ability of the HAMP domain region to regulate AC activity. The effect of the HAMP domain on the CHD of Rv1319c was much less pronounced, supporting the earlier notion of a ... investigated the HAMP domain function in the context of mycobacterial class IIIb ACs. The isolated CHDs of all four isoforms were purified and had A...

Ngày tải lên: 23/03/2014, 12:20

... also consider the way intonation affects the interpretation of a sentence, especially the cases in which it alters the predictions of centering theories. I investigate this via a phenomenon that, ... tone and an optional leading or trailing tone. The form of the accent L, H, L+H or H+L informs about the operation that would relate the salient item to the mutual...

Ngày tải lên: 20/02/2014, 22:20

... concentrations of Arg-HCl in the absence of the chaperone precluded analysis of the effect of this concentration on the protective ability of aB-crystallin. Reduction-induced aggregation of the insulin ... aggregation. We report that the effect of these additives on the chaperone action of aB-crys- tallin is dependent on the target protein used, and t...

Ngày tải lên: 18/02/2014, 16:20

... deviation (RMSD) from the Ca atoms of the wild- type crystal structure [11] of 0.33 A ˚ . The electron density in the area local to the substitution is shown in Fig. 4. The positions of catalytic ... hydrogen bonds to be formed between the base G 4 and the sidechain of Asn122. In the second model (Fig. 1B) the structure of the hexanucelotide is, on the wh...

Ngày tải lên: 19/02/2014, 12:20

... interactions (Fig. 4D). Effect of the M100K mutation on the stability of the native state The effect on protein stability upon introduction of a Lys ligand to the heme-iron has been assessed for the M100K ... postulated to arise from the deprotonation of an ionizable group (the ‘trigger’) the nature of which is as yet unknown. For the M100K variant it se...

Ngày tải lên: 07/03/2014, 17:20

... side-chains of Arg45 and Lys96 (Fig. 8). These interactions conceiv- ably also contribute to the conformational stability of holo-lMb. Consistently, they are maintained over the 1.5 ns of the simulation ... in the first 0.5 ns of MD simulation, triggering the unfolding of helix E and the subsequent global unfolding of the structure. In holo-lMb, the shielding effec...

Ngày tải lên: 16/03/2014, 06:20

... rather than words. The other factor is the translation resources com- prised in the MT system. Our observation showed that the size of the dictionary has a stronger effect on retrieval effectiveness ... on dictionary-based degradation comparable to the results on rule-based degrada- tion, we degrade the dictionary so that the varia- tion interval on translation...

Ngày tải lên: 17/03/2014, 04:20

... leave- one-out setting (359 times training on 358 questions and evaluating on the re- maining questions). The prospective application of the third series of experiments is the development of a ... next block of charac- ters (the ‘predictive unit’). If the user gets correct suggestions for continuation of the text then the number of keystrokes needed to type the...

Ngày tải lên: 17/03/2014, 22:20

... recogni- tion, the ionic strength of the medium would be expected to have an effect on the binding [43]. To study the effect of ionic strength on the conformation of ToxRp in the presence of ZnO ... knowledge of the mechanism(s) of association and interaction of proteins with the particle surface and the consequent effect on the structure of th...

Ngày tải lên: 23/03/2014, 03:20

... reciprocal of the apparent V max was plotted against the concentration of inhibitory product and the inhibition constant for the inter- cept effect (K ii ) was determined from the intersection on the inhibitor ... [5]. Questions on the possible function of BVR-A in cyanobacteria parallel a major re-evaluation of the function of BVR-A in mammals. Once consider...

Ngày tải lên: 23/03/2014, 05:22