Báo cáo khoa học: Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation Quercetin as an effective antioxidant against pro-oxidant effects of urate potx

... searches of b-amino acids were initially carried out at intervals of 30° for each torsion angle /, h,andw and were subsequently refined by varying /, w angles in intervals of 10° and setting h angle ... Torrens, Y., Beaujouan, J C. & Glowinski, J. (1993) Importance of the leucine side-chain to the spasmogenic activity and binding of substance P analogues. Int. J. Peptide...

Ngày tải lên: 08/03/2014, 08:20

... Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation Quercetin as an effective antioxidant against pro-oxidant effects of urate Paulo Filipe 1,2 , ... that • UH – wouldalsobe involved in the pro-oxidant action of urate. Interestingly, at high Cu 2+ concentration, in the presence of 0.5 l M querce...

Ngày tải lên: 23/03/2014, 12:20

... area of the White Moun- tains of California. Details of animal holding, feeding and hibernation were described in [15]. All possible measures were taken to minimise pain and discomfort during animal euthanasia ... stability of plasma glucose levels [1,3,4]. In hibernators, the aci- dotic conditions found in muscle during hibernation can lead to an increase in histidine p...

Ngày tải lên: 19/02/2014, 16:20

... UK Horseradish peroxidase (HRPC) is a member of class III of the plant peroxidase superfamily and is cap- able of utilizing hydrogen peroxide to oxidize a wide range of phenols, anilines and other synthetic ... features can also exert an important in uence in determining the electronic structure of the haem pocket. To extend our understanding of the significance of proxi...

Ngày tải lên: 07/03/2014, 21:20

... by: hE INT i¼E min complex þ N complex k B T 2 À E min protein À N protein k B T 2 À E min ligand À N ligand k B T 2 ð2Þ and as N complex ¼ N protein +N ligand , hE INT i¼DE ¼ E min complex À E min protein À ... reduction in the K i for the inhibition of AdoHcy hydrolase and a corresponding 25- and 13-fold decrease in the inhibition of HIV-1 A012 and A018 p24 antigen in PB...

Ngày tải lên: 08/03/2014, 08:20

... activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol 22, 609–613. 28 Papandreou I, Cairns RA, Fontana ... Japan Introduction Our previous studies showed that an oral low dose of donepezil, an acetylcholinesterase inhibitor and anti- Alzheimer’s disease drug, prevented ventric...

Ngày tải lên: 23/03/2014, 05:22

... of neu- rolysin and TOP was reported using internally quenched fluorescent (IQF) peptides derived from bradykinin [5] and neurotensin [6]. An outstanding feature of the hydrolytic activities of ... unspecific cleavage of other proteins and it is of particular relevance for TOP and neurolysin as they are not expressed as inactive precursors and they are present in hig...

Ngày tải lên: 23/03/2014, 21:21

... inducer of neovascularization, and plays an important role in tumor growth [5]. Eosinophil-derived neurotoxin (RNase 2) and eosinophil cationic protein (RNase 3) have antibacterial and antiviral activities. ... regarding a new class of surrogates for the phosphoryl group. Results and Discussion Sulfonimides as inhibitors of RNase A We began by determining the ability of...

Ngày tải lên: 14/02/2014, 22:20

... activity and is measured at saturating concentrations of IMP and sub-saturating concentrations of inosine. The K 50 for ATP was measured as phosphotransferase activity, while for Mg 2+ , it was measured ... behav- iour of recombinant wild-type enzyme in the presence of ATP and Mg 2+ as an activator and P i as an inhibitor. Figure 5 shows that the enzyme exists and...

Ngày tải lên: 15/02/2014, 01:20

... with guanine and hypoxanthine bases, respectively, indicating that Asp137 functions as a catalytic base [12]. However, a tight binding of N7 of the purine base and Asp137 was observed in HPRT in ... PRTFDC1 and hypoxanthine. (B) HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine. Table 2. K m and V max values for Hx and G in the presence of 1 mM...

Ngày tải lên: 15/02/2014, 01:20