Báo cáo khóa học: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy pdf
Báo cáo khóa học: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy pdf
... CAG AGC GG btf 377–5¢ AAC ATA TGG ATC AGG AAG CTC TAG ATT AC 521–5¢ AAC ATA TGG CAC GAG AAA AGT CTA CCT TC 574–3¢ TTG GAT CCT TAT GTA CTA GCA AGC AGC C 646–3¢ TTG GAT CCT TAT TGC CGA GTA CTA ... 175SSL 175 AAA 192 192SSSSS 192 ASAAA 198 198SSWLTR 198 AAAAA 206 206IRPE 206 AAPA 24 24GPVV 24 AAAA 34 34YEKK 34 AAAA S54F 54S 54 F 70 70DADMY 70 AAAMA 76 76LPKKEDAL 76 APAKADAA 112 112GPSRAVRGSVT .....
Ngày tải lên: 23/03/2014, 12:20
Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx
... titration calorimetry. Probing calcium -binding by Stains-All assay Calcium -binding to bB2- and bA3-crystallins was eval- uated by calcium probe Stains-All, a carbocyanine dye [29]. The dye binds the recombinant bA3- and ... SC, Somasunda- ram T, Gopalakrishna A & Balasubramanian D (1989) Calcium ion binding to d- and to b-crystallins. Presence of EF-hand motif in d-cry...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1 doc
... Y.Y., Tyurin,V .A. ,Thampatty,P.&Fabisiak,J.P.(1999)Mechanism- based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach. Mol. Phar- macol. ... simplicifolia), a Rutaceous tree widely distributed in Australia [1,2]. This tetracyclic alkaloid was shown to be moderately cytotoxic to a wide range of tumor cells in vitro [3,4]...
Ngày tải lên: 20/02/2014, 11:20
Báo cáo khoa học: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme–albumin doc
... of tHSA–heme and HSA–heme by binding to the low-affinity secondary sites FA2 and FA6 rather than associating with the primary-high affinity cleft FA3–FA4; and (b) reinforce the idea that HSA could ... of ibuprofen. Data analysis Kinetic and thermodynamic data were analyzed with the matlab program (The Math Works, Natick, MA, USA). The results are given as mean values of at least four ex...
Ngày tải lên: 06/03/2014, 01:20
Báo cáo khoa học: Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives ) a screening based on affinity for the UMP-CMP binding site potx
... mm) that displaced MABA-CDP were further studied in competition titrations. The IC 50 value at half-displacement was related to the D. Topalis et al. UMP-CMP kinase and acyclic phosphonate analogs FEBS ... on affinity for the UMP-CMP binding site Dimitri Topalis 1, *, Hiroki Kumamoto 2, *, Maria-Fernanda Amaya Velasco 3, *, Laurence Dugue ´ 4 , Ahmed Haouz 5 , Julie Anne C. Alexandre 1 ,...
Ngày tải lên: 07/03/2014, 09:20
Báo cáo khoa học: Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization potx
... Irr, a- pro- teobacteria that are closely related to Rhizobium, Agro- bacterium, Brucella and Bartonella contain another wide-ranging iron-responsive regulator called RirA [16–19]. RirA belongs to ... A decreased level of oligomeriza- tion was also observed in the His-free variant, although this was both before and after the addition of heme. By contrast, H3 9A, H9 3A, H9 4A and H...
Ngày tải lên: 28/03/2014, 22:21
Báo cáo khoa học: Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity pdf
... enhanced the transcrip- tional activity of Gal4-dHAND-WT, indicating that E47 bound to Gal4-dHAND and functioned as a strong transcriptional activator. Gal4-dHAND-Ala-X and Gal4- dHAND-Ala also ... residues one by one with alanine (dHAND- 1TA, 2TA, 3SA, 4TA, 5TA and 6TA; Fig. 3A) . Among these mutants, dHAND-1TA demonstrated partial but substantial decrease in phosphorylation (Fig....
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... activated by magnesium and manganese [39]. Activation of GC-B by CNP also leads to desensitization of GC-B after brief treatment with ligand, and here again, this is accom- panied by a decrease ... ANP-mediated activation [38]. Recent studies have indicated that GC -A is possibly dephosphorylated by two phosphatases, a micro- cystin inhibited phosphatase and another phosp...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... pcDNA3.1-HSP70 DPBD CTGATGGGGGACTCCTACGCCTTCAACATGAAGAGC Antisense of pcDNA3.1-HSP70 DPBD GAAGGCGTAGGAGTCCCCCATCAGGATGGCCGCCTG Sense of pcDNA3.1-HSP70 DATP-BD AAAAGGATCCAAAGTCCGAGAACTGGCAGGAC Antisense of pcDNA3.1-HSP70 DATP-BD TCGGGTACCGGATCTACCTCCTCAATGGTG B. ... cytochrome c associates with apoptosis protease-activating factor-1 (Apaf-1) and then binds to and activates caspase-9 in the p...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: "From Extractive to Abstractive Meeting Summaries: Can It Be Done by Sentence Compression?" pdf
... automatic speech recogni- tion (ASR) output. Various approaches to extractive summarization have been evaluated recently. Popular unsupervised approaches are maximum marginal rele- vance (MMR), latent ... grammar (SCFG) deletion rules. Unlike these ap- proaches that need a training corpus, (Clarke and La- pata, 2008) encoded the language model and a variety of linguistic constraints a...
Ngày tải lên: 23/03/2014, 17:20