Báo cáo khóa học: Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II potx
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... constitutes the second largest family of cyto- plasmic tyrosine kinases. In 1993, loss -of- function mutations in the BTK gene were reported as the cause of X-linked agammaglobulinemia. Of all the existing ... of all mutations in the BTK gene are missense and some of these reduce the stability of the protein. This is exemplified by mutations in the BTK motif of...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: Three-dimensional structures of thermophilic b-1,4-xylanases from Chaetomium thermophilum and Nonomuraea flexuosa Comparison of twelve xylanases in relation to their thermal stability pdf
... However, the extension of the N-terminus of TRX II has been reported to increase the thermostability [57]. The third region with effect on the thermotolerance seems to be the Ser/Thr surface. The ... some of the trends in the amino acid frequencies could be related to the thermostability of xylanases. There was found an increased occurrence of arginines in the...
Ngày tải lên: 20/02/2014, 23:20
Tài liệu Báo cáo khoa học: "Three BioNLP Tools Powered by a Biological Lexicon" doc
... of the BioLexicon, in order to illustrate the utility of the lexicon within the biomedical NLP field. The three applications are: • BLTagger: a dictionary-based POS tagger based on the ... • bigram of adjacent POS • bigram of adjacent BIOMED • bigram of adjacent POS-BIOMED During the construction of the trellis, white space is considered as the del...
Ngày tải lên: 22/02/2014, 02:20
Báo cáo khoa học: Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1 doc
... describe the identifica- tion of the novel metabolites, and the mechanism of a three- step hydroxylation by the R73V ⁄ R84A variant. In addition, we evaluated the biological significance of the recombinant ... stability of the oxygenated forms of the wild-type CYP105A1 and its variants. Figure 8 shows spectral analysis of the NADPH- dependent reduction of heme i...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Three novel carp CXC chemokines are expressed early in ontogeny and at nonimmune sites ppt
... arguably the most pleiotropic CXC chemokine. But the key to the conservation of CXCL12 is not so much the myriad of functions it is involved in, but in the critical importance of some of these functions ... in case of the deletion of one receptor, allows the other to take over the majority of its functions. The fact that fish have duplicate genes for both CXCL12...
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: "Veterinary decision making in relation to metritis - a qualitative approach to understand the background for variation and bias in veterinary medical records"
... category of motivation, but they might have been more or less focussed on each of the three levels/categories of motiva- tion. At the level of the individual cow, the veterinarians seemed to base their ... the collection of the data in and of itself as the basis for taking relevant action at the farm. They may skip the process of systematic anal- ysis of da...
Ngày tải lên: 25/10/2012, 10:45
Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... MT protect the liver and the heart against the toxic effects of ethanol [45–47]. The above results suggest that a critical aspect of the protective function of MT is the scavenging of the acetaldehyde formed ... none of the aldehydes affects the absorbance of PAR. The data for the reaction of MT with formalde- hyde were corrected for the absorbance change...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt
... Exon–intron structure of the Hu-K4 gene. (A) Position of the exons on the BAC clone CTC-492K19 (GenBank AC010271.8). The first and the last nucleotide of each exon are given. The positions of the polyadenylation ... site, the stop codon and the putative start codons ATG 1 and ATG 4 are indicated. The size of exons 1–5 is drawn in scale. (B) Alternative splicing o...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 pptx
... subunit of PDH2 and the a subunit of the T. profundus enzyme, respectively (Fig. 3), while the b1 subunit showed 56% and 64% sequence identities with the b2 subunit of PDH2 and the b subunit of the T. ... show the amino-acid alignment of the a and b subunits of PDH1, PDH2 and T. profundus dye-l-proDH. The amino-acid sequence of the a1 subunit of...
Ngày tải lên: 20/02/2014, 01:20
Báo cáo khoa học: How a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden pdf
... used to predict the outcome of disease, and to guide the choice of thera- peutic regimens. Fig. 3. Alternative tumour suppressor mechanisms of PI3K-III. Three alternative (hypothetic) tumour suppressor ... ESCRT-III is recruited, cargo is deubiquitinat- ed by deubiquitinating enzymes recruited by ESCRT-III [61], and ESCRT-III serves to sever the neck of the forming invaginat...
Ngày tải lên: 06/03/2014, 01:23