Báo cáo khóa học: Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon pot
Báo cáo khóa học: Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon pot
... Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon Tom Samiric, Mirna Z. Ilic and Christopher J. HandleySchool ... work shows that the pathways ofcatabolism for large aggregating and small leucine-rich proteoglycans are different in tendon and this may reflectthe roles that these two populations of proteoglycans ... large and small proteoglycans follow distinct separate pathways. Furthermore, it is evident that in both tendon and ligament[4] t he processes involved in the catabolism of proteoglycans are similar...
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Tài liệu Báo cáo khoa học: Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects doc
... effect being efficiently increased by a cathepsin B ⁄ cathepsin Dpretreatment. The data show a novel processing pathway for internalizedETA, involving cathepsins B and D, resulting in the production ... generated by cathepsin B and cathepsin D. (A) Native ETA (10 lg) was incubated withbovine cathepsin B or cathepsin D (5 UÆmL)1Æmg)1), or a mixture of both, at 37 °C for the indicated times in ... (B) were isolated at the indicated times after the in vivo administration of native ETA, and evaluated fortheir content of internalized toxin by nonreducing (upper blots) and reducing SDS ⁄ PAGE...
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Báo cáo khoa học: Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage docx
... glutathione and by cysteine residues in the active sites of pro-teins such as thioredoxin and peroxiredoxin. In addition, there are thiolsexposed on protein surfaces that are not directly involved ... pre-pared by disruption of bovine heart mitochondria in a blen-der, followed by collection and washing by centrifugation[45]. These preparations had negligible matrix contamina-tion, as indicated ... followed by freeze ⁄ thawing (·3) gave levels of exposed and total protein thiols similar to that shown in Fig. 1(data not shown). Denaturing proteins by incubation with8 m urea gave a total protein...
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Báo cáo khoa học: Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin pptx
... investigate the effect of sCLU and Bcl-2 overexpression on VOSO4-induced apoptosis ofHaCaT cells, DNA and proteins were isolated fromfloating and attached HaCaT NeoT, HaCaT sCLU and HaCaT ... genesinduced by proteinuria and identified usingDNA microarrays. Clin Exp Nephrol 12, 181–188.77 Perkins ND (2007) Integrating cell signalling pathways with NF-jB and IKK function. Nat Rev ... oncopro-tein was expressed at high levels in normal adult skin[35] and its expression was increased in epidermal cells in late stages of differentiation, but not in proliferativecell populations...
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Báo cáo khoa học: NblA from Anabaena sp. PCC 7120 is a mostly a-helical protein undergoing reversible trimerization in solution pot
... disrupted by sonication and centrifuged (14 000 g for 10 min at 4 °C). (NH4)2SO4wasadded to the supernatant (30% saturation, 10 min centri-fugation at 14 000 g at 4 °C), the pellet dissolved in ... thermal denaturation of NblA (C) and CD spectra at various temperatures and after recooling (D). (A) The spectra were measured in 20 mMsodium phosphate buffer, pH 7.5 (thin line)andinthepresenceof7Mguanidine ... ascer-tained by Monte-Carlo simulations of the fitted data, using10 000 iterations for each dataset. From this, the 95%confidence intervals were obtained and are reported for themolecular mass and...
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Báo cáo khoa học: Trans-splicing of a mutated glycosylasparaginase mRNA sequence by a group I ribozyme deficient in hydrolysis pptx
... schematic map of thehuman GA ORF indicating the intron inser-tion site at position 436. Mutations at posi-tions 488, 800 and 916 are frequentlyassociated with the most common lysosomaldegradation ... GA band; RNA 4, major DiGIR2 AGU and DiGIR2DP9.2 AGU band. Additional bands result from degradation of RNA during incubation at trans-splicing and RPA hybridizationconditions. Below; quantitation ... software). Thecytosine content in the part of the RPA probe protected by the different sized RNAs was calculated and includedas a theoretical value to make the intensities of different sized bands...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... a-lactalbumin(0.5 mgÆmL)1) or bovine insulin (0.25 mgÆmL)1) were incu-bated at 37 °Cin50mm phosphate buffer, pH 7.2, contain-ing 100 mm NaCl, and aggregation and precipitation wasinitiated by ... precipi-tation of insulin at intermediate and high concentra-tions, and it also increased the activity of aB-crystallin in preventing the aggregation leading to amyloid fibrilformation by a-synucleinA53T ... incubation at 37 °Cin50mm phosphate buffer, pH 7.2, without shakingfor 15 h. Single-point ThT readings were taken for a-synu-cleinA53T during incubation at 37 °Cin50mm phosphatebuffer containing...
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Báo cáo khoa học: "Large-Scale Cross-Document Coreference Using Distributed Inference and Hierarchical Models " pptx
... for learning by reading. In AAAI Spring Symposium on Learning by Reading and Learning to Read.Andrew McCallum and Ben Wellner. 2004. Conditionalmodels of identity uncertainty with application ... link anal-ysis, and inference. In International Conference onIntelligence Analysis (ICIA).Nader H. Bshouty and Philip M. Long. 2010. Find-ing planted partitions in nearly linear time using ... and Michael Hay. 2004. An integrated, conditional modelof information extraction and coreference with appli-cation to citation matching. In Uncertainty in ArtificialIntelligence (UAI), pages...
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Báo cáo khoa học: "Large Scale Collocation Data and Their Application to Japanese Word Processor Technology" potx
... conversion, focusing on the usage of large scale collocation data. In chapter 2, descriptions of the collocations used in our sys- tem and their classification are given. In chapter 3, the ... The latter is further classified into two kinds: uninter- ruptible collocations, whose concurrence relation- ship of words are so strong that they can be dealt with as single words, and interruptible ... are used in the actual segmentation process. The interruptible conceptual collocation is not treated as a single unit but as a string ofbunsetsus in the segmentation process. Each collocation...
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Báo cáo khoa học: "Large-Scale Induction and Evaluation of Lexical Resources from the Penn-II Treebank" potx
... annotation principles, one fornon-coordinate configurations, one for coordinateconfigurations, one for traces (long distance depen-dencies) and a final ‘catch all and clean up’ phase.Distinguishing ... relative subcat-egorization frequency for individual predicates”. In contrast, the system of (Briscoe and Carroll, 1997)distinguishes 163 verbal subcategorisation classes by means of a statistical ... forms associated with each predicate.Section 2 reviews related work in the area ofautomatic subcategorisation frame extraction. Ourmethodology and its implementation are presented in Section...
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