Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc

... analysis of HIF- 1a and HIF-2a protein stability and transactivation potency that have provided the greatest insights into oxygen sensing and regulation. HIF protein stability Initial biochemical ... basic DNA binding region and HLH primary dimerization inter- face. The adjacent PAS domain is comprised of approxi- mately 300 amino acids and is subdivided into two semi conserve...

Ngày tải lên: 20/02/2014, 23:20

... affected similarly, with no effect by inhibiting PLC-b (Fig. 5A), strong down -regulation of collagen I levels after inhi- bition of PC-PLC (Fig. 5B), and similar collagen I down -regulation after PLD inhibition ... strong inducer of collagen I synthesis [3,14]. Further investigations should reveal if ET-1 eli- cits induced collagen I synthesis solely via ind...

Ngày tải lên: 23/03/2014, 11:20

... exceptional vari- ability in basal enyzme activities. Although in the holoenzyme this variability was greatly reduced by addition of linoleic acid, the extent of stimulation was diminished in protein ... mixture of conformations of different specific activities, and that (b) fatty acids Fig. 4. Kinetic analyses of the stimulation of Rv2212 1)388 by 100 l M linoleic acid (A)...

Ngày tải lên: 30/03/2014, 10:20

... circularized I linear, we hybridized oligonucleotide H17 to the DNA segment of I encompassing the recognition sequence of HhaI before restriction digestion. With this modifica- tion, essentially a single ... 10 )5 n.d. Fig. 4. Investigation of ssDNA ligation activity of different DNA ligases. Oligonucleotide I (10 n M) was incubated with ligase, cleaved by HhaI, and subjected...

Ngày tải lên: 23/03/2014, 11:20

... activator of Sir2 activity [41]. Isonicotinamide was shown to directly compete with nicotinamide for binding. Nicotinamide is a potent inhibitor of the Sir2 reaction because of its aforemen- tioned ... adenine mimics. If this is the case, then it is likely that they possess activity against other NAD + binding enzymes. This effect is seen with nico- tinamide, which in addition to its Si...

Ngày tải lên: 20/02/2014, 01:20

... Supervised and Unsupervised Training for Disambiguation Michaela Atterer Institute for NLP University of Stuttgart atterer@ims.uni-stuttgart.de Hinrich Sch¨utze Institute for NLP University of Stuttgart hinrich@hotmail.com Abstract We ... attachment possibilities based on pointwise mutual information, the well-known measure of how surprising it is to see R and X together given their...

Ngày tải lên: 20/02/2014, 12:20

... explicitly assign such categories. The part of speech of a marker (conjunctive, subordinating conjunction, coordinating con- junction, preposition) determines the possibil- ities of positioning ... detailed studies of individ- ual groups of markers, such as [Vander Linden, Martin 1995] for PURPOSE markers. Besides, the Linguistics literature offers fine-grained analyses...

Ngày tải lên: 20/02/2014, 18:20

... recruit- ment of adaptor and signalling proteins, initiate multi- ple signalling events [16–20]. The EGFR is implicated in the control of cell proliferation and differentiation, cell survival, ... in an inactive but pre-dimerized ⁄ oligomerized state, which is subsequently activated after ligand binding by inducing the rotational reorga- nization of both monomers, with such an...

Ngày tải lên: 06/03/2014, 09:22

... understanding of infection, spread and dissemination through splicing regulation. Such stud- ies coupled with the testing of splicing inhibitors should help the develop- ment of new therapeutic antiviral ... infec- tious particles. IDC16 inhibits replication of macro- phage- and T cell-tropic laboratory strains, clinical isolates and strains with high-level resistance to inhibi...

Ngày tải lên: 06/03/2014, 09:22

... acidic and five aliphatic amino acids), iturin As (heptapeptide consisting of six polar amino acids and a proline) and iturin Cs (heptapeptide consisting of five polar and an acidic amino acids as ... activity [62]. Thus, the reciprocal activation of scu-PA and plasminogen constitutes a mechanism of localized initiation and propagation of pericellular proteolysis [63–66]...

Ngày tải lên: 06/03/2014, 22:21