Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf

... key role in minimizing cell injury and maintaining tissue integrity in response to damaging levels of an environmental agent. As such, the integrity of this system plays a role in modifying progression ... clinical model that is giving novel molecular mechanistic insight is adenocarcinoma of the oesopha- gus [2]. This cancer is one of the fastest rising cancers...

Ngày tải lên: 23/03/2014, 10:21

... for 2 h) cells, indicating that interaction with Smac is not required with respect to the role of HSP70 in the inhi- bition of the release of Smac and apoptosis. The role of the ATP-binding domain ... interaction of HSP70 with apoptosis signal- regulating kinase 1 (ASK1) and the inhibition of ASK1-induced apoptosis in vitro [28]. Furthermore, the ATP-bi...

Ngày tải lên: 16/03/2014, 01:20

... activities of FasL is to induce in ammation in vivo [15–18], and this in ammatory activity of FasL seems to play deleterious roles in inflammatory diseases [19–21]. Consistent with its in ammatory activity, ... death effector domain (DED) of FADD], forming death-inducing signaling complex [1–4]. Depending on the cell type, the upstream caspases activated in this comp...

Ngày tải lên: 07/03/2014, 09:20

... 132 amino acid domain C-terminal to the HD in Meis2d. We therefore suggest that the autoin- hibitory function of the Hth domain in Meis2d is likely to be a common feature of Meis family proteins. Switching ... similar isoform. It has been suggested that Pbx proteins are the major DNA-binding partners for Meis proteins, consistent with the presence of an intact...

Ngày tải lên: 16/02/2014, 15:20

... studies of the actin binding domain of spinophilin. We demonstrate that the spinophilin actin binding domain is intrinsically unstructured, and that, with increasing C-terminal length, the domain ... spinophilin sequence with the positions of the construct limits used in this study and domain borders indicated by numbers. The core actin binding domain, PP1 bindi...

Ngày tải lên: 16/03/2014, 06:20

... besides occurring in DnaG C-terminal domains, has been described only for the N-terminal domain of DnaB. The C-terminal helix hairpin present in the DnaG C-terminal domain, however, is either less ... helicase forms a hexameric ring structure with up to three molecules of the DnaG primase attached [2–4]. DnaG is composed of three main domains comprising an N-termi...

Ngày tải lên: 16/03/2014, 12:20

... program of CYANA (1.0) [31]. On the basis of these distance constraints obtained using the macro CALIBA ,a systematic analysis of the local conformation around the C a atom of each residue, including ... detected in any of the 16 conformers, while the H-bonds between Asp14 and Phe18 were missing in the majority of the 16 conformers, indicating that the struct...

Ngày tải lên: 16/03/2014, 16:20

... This is indicated by the average activity of mutants in the central domain of 26% for WAF1 and 34% for MDM2, 71% for NOXA and 61% for p53R2, and around 45% for the other four promot- ers. For ... binding and 244 and 246 are in very close proximity to DNA binding. This indi- cates that p53R2 either does not use these residues for binding or that they are not n...

Ngày tải lên: 18/02/2014, 11:20

... appears to recognize its substrate by indirect readout of a protein induced RNA structure [21]. It is therefore interesting to note that hairpin 35 of the 23S rRNA (another substrate for RluA) ... the pseudouridine formation may lie within the flipped out conformation of H69 because base flipping is obligatory for Y synthesis [4]. The cocrystal structure of E. coli...

Ngày tải lên: 18/02/2014, 16:20

... environments of BPA in the ligand-binding pocket of the ERRc. The proximity of each amino acid residue (within a distance of 5 A ˚ ) to BPA is shown in the boxes depicting the a -heli- ces. The portrait ... group of bisphenol A and estrogen-related receptor c residues Glu275 and Arg316 in the ligand-binding domain. By inducing mutations in other amino acid...

Ngày tải lên: 18/02/2014, 16:20