Báo cáo khoa học: Local binding with globally distributed changes in a small protease inhibitor upon enzyme binding ppt

... The Authors Journal compilation ª 2006 FEBS Local binding with globally distributed changes in a small protease inhibitor upon enzyme binding Zolta ´ nGa ´ spa ´ ri 1 , Borba ´ la Szenthe 2 , Andra ´ s ... discrep- ancy may be, at least in part, due to the insufficient sampling of relaxation parameters as data is available A B DC Fig. 3. (A, B) Chemical shift c...

Ngày tải lên: 23/03/2014, 10:21

... of a training data. The sec- ond term is a regularizer that is used for reducing overfitting in parameter estimation. 3 Latent-Dynamic Inference On latent conditional models, marginalizing la- tent ... latent variables are advantageous in learning (Matsuzaki et al., 2005; Petrov and Klein, 2007; Blunsom et al., 2008). Actu- ally, discriminative probabilistic latent variable models (DPL...

Ngày tải lên: 17/03/2014, 22:20

... biochem- ical data, along with previous observations that the sku mutant accumulates isovaleric acid and branched- chain amino acids, strongly indicate that a single amino acid substitution (G376V) in ... most intriguing features of the sku mutant is that the mature larva accumulates branched-chain amino a cids, leucine, isoleucine and valine, in haemolymph at levels  4 times highe...

Ngày tải lên: 18/02/2014, 04:20

... semantic analysis, and pragmatic analysis. Each stage has been designed to use linguistic data such as the lexicon and grammar, which are maintained separately from the engine, and can easily ... resources into our natural language understanding system. Client- server architecture was used to make a large volume of lexical information and a large knowledge base available to the sy...

Ngày tải lên: 20/02/2014, 18:20

... and new information in formulating a paraphrase that differs in a meaningful way from the user's question. A description is also given of the transformational grammar used by the paraphraser ... represent information assumed by the questioner to be true of the database domain. This lapeling of information within the question will allow the construction of a natural pa...

Ngày tải lên: 21/02/2014, 20:20

... pre-pro-tyrosinase (Fig. S1) can be divided approximately into three domains: a twin arginine translocase (TAT) signal peptide, a core domain con- taining the two copper -binding motifs and a C-termi- nal ... constructs without the predicted N-terminal signal peptide (amino acids 1–36), we retained amino acid 36, an alanine, rather than using amino acid 37, a lysine, because it is kn...

Ngày tải lên: 06/03/2014, 11:20

... terrain. S S AA AA AS When the settlers becomes active, chose build road. A AS SS A Use settlers or engineers to improve a terrain square within the city radius A A A SA SSSSS ✘✘ Phalanxes are ... built -in AI. 7 Results Game performance As shown in Table 1, our lan- guage aware Monte-Carlo algorithm substantially outperforms several baselines – on average winning 53.7% of all ga...

Ngày tải lên: 07/03/2014, 22:20

... with 6-aminoquinolyl-N-hydroxysuccinimidylcarbamate (using a Waters Accq-Tag amino acid analysis system; Waters Cor- poration, Milford, MA, USA) and reversed-phase liquid chromatographic separation (see [25] for a full ... ultrapure water. Free amino acids were assayed as described by Bouche- reau et al. [25]. Amino acids were characterized and quanti- fied by HPLC after precolumn deriva...

Ngày tải lên: 16/03/2014, 11:20

... AATTCTCGAGTGCTGCTGCTGCCGTTGCTGC 6F-XHO AATTCTCGAGTGCTGCTGCTGCGAATGCTGC C3K -A7 K GCCGGGATCCATGGGCAAAACGCTGAGCAAAGAGGACAAGCTCGAG HC-K 7A GCCGGGATCCATGGGCAAGCAGAATAGCGCACTGCGGCCAGACAAG MG3K6S GCCGGGATCCATGGGCAAGGCAGCATCTGCAGCAGCAGCAGACAAGCCTGTAGCC MG3K6S7K ... (5¢fi3¢) MA(9) ATATGGATCCATGGCTGCGGCAGCAGCGGCAGCAGCAGCAGACAAGCCTGTAGCC MGA(8) ATATGGATCCATGGGCGCGGCAGCAGCGGCAGCAGCAGCAGACAAGCCTGTAGCC MG...

Ngày tải lên: 16/03/2014, 16:20

... remains unclear, but one could expect that in a particular niche this structure may confer an advantage upon the bacterium, thus aiding its competitiveness in maintaining an infection. ACKNOWLEDGEMENTS We ... structural analyses on meningococcal core oligosaccharides had been per- formed following O-deacylation and/or dephosphorylation. Naturally, base-labile residues that may have be...

Ngày tải lên: 23/03/2014, 21:21