Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in afﬁnity of transthyretin to T4 and T3 pdf

Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt

... ubstrate of KDRkinase, i s then phosphorylated and activated, leading to the activation of p rotein kinase C (PKC), followed by the serine/threonine kinase, Raf1 and then the threonine/tyrosinekinase, ... clonedchemokine receptor isoform named CXCR3B [34]. W etherefore studied the involvement of this receptor in the inhibition, by PF-4, of VEGF-indu ced MAP kinaseactivation and proliferation of HUVEC. ... following the addition of PF-4(10 lgÆmL)1). This is consistent with partial inhibition of the binding of VEGF165 to its receptor [26]. How ever, the levels of tyrosine phosphorylation of the...

Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in afﬁnity of transthyretin to T4 and T3 pdf

... To determine the in uence of the N-terminal region of TTR on the binding to thyroid hormones, the con-struction of chimeric recombinant TTRs containingvariations in structure of the N-terminal ... both of which preferentially bound T3 over T4. Here, we tested that hypothesis that the structure of the N-terminal region in uence the binding of T3 and T4 to TTR by comparing the afﬁnities of T3 ... that the N-terminal region exert a greater in uence on the afﬁnity of T4 than on the afﬁnity of T3. This couldimply that the core of TTR has a major in uence in determining the afﬁnity of T3 and the...

Tài liệu Báo cáo khoa học: "Identifying Linguistic Structure in a Quantitative Analysis of Dialect Pronunciation" docx

... papers the identiﬁcation of linguistic structure in the aggregate analysis is based on the analysis of the pronunciation of the vowels found in the data set. In work presented in this paper the ... e.g., the ﬁrst vowel in the word ’Wash-ington’ or the second vowel in the word ’thirty’.Factor analysis has shown that 3 factors are most im-portant, explaining 35% of the total amount of vari-ance. ... parts: the aggregate analysis of Bulgarian di-alects on one hand, and the identiﬁcation of linguis-tic structure in the aggregate analysis on the other. In this section the work closely related to...

Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf

... following the ﬁrst helices of domains 1 and 2, respectively. The EF-hand-like calcium site of domain 2 was describedearlier, and tight binding of the ion was shown to con-tribute to the integrity of ... but rather to that of the larger maltose-bind-ing protein. This kind of protein is exempliﬁed by the Thermus thermophilus protein, PDB entry 2B3B [28]. The mode of binding the monosaccharide ... binding proteins are abundant in bacteria by virtue of theiressential roles as high -afﬁnity receptors in ABC transport systems and chemotaxis. One of the best studied of these receptors is the...

Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc

... variants of the illness are considered to beprimarily autoimmune in nature [1]. The 18.5 kDaisoform of myelin basic protein (MBP) is one of the most abundant proteins in CNS myelin; MBP maintains the ... families created by the iso-tropic mixing of the TOCSY experiments [36]. The sequence-speciﬁc assignment of these spin systems wasdeduced from the ‘ﬁngerprint’ regions of the TOCSY and NOESY experiments, ... hydrophobic interior of the micelles. These molecules act locally as strong signal-relaxing agents, causing a broadening proportional to the inverse of the average of the distance to the sixthpower...

Tài liệu Báo cáo khoa học: "An API for Measuring the Relatedness of Words in Wikipedia" docx

... calling Perl routines from the Java API.Perl routines take care of the bulk of querying ency-clopedia entries to the MediaWiki software (which in turn queries the database) and efﬁciently parsing the ... based on the link structure of the articles);3. computing paths in the Wikipedia categoriza-tion graph between the categories the articles areassigned to; 4. returning as output the set of paths ... simple inter-face to create and access the encyclopedia pageobjects and compute the relatedness scores. The information ﬂow of the API is summarized by the sequence diagram in Figure 2. The higher...

Tài liệu Báo cáo khoa học: "HOW DO WE COUNT? THE PROBLEM OF TAGGING PHRASAL VERBS IN PARTS" docx

... assignment. In the case of to gun down the ambiguity of to is enhanced by the ambiguity of gun, and a mistake in tagging gun will automatically lead to an incorrect tagging of to as a ... between the verb and the particle in order to optimize the perfor- mance of the tagger. 3. THE EXPERIMENT 3.1. DATA The first step in testing this hypothesis was to evalu- ate the current ... preposition instead of verb + particle. This error influences the tagging of other words in the sentence as well. One typical error is found in infinitive constructions, where a phrase like to gun...

Tài liệu Báo cáo khoa học: Solution NMR structure of ﬁve representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity doc

... conformers. The case of the nystatin A1 is interesting regarding itsinteraction with the sterols and its incorporation intomembranes. Unlike to ﬁlipin III, a polyene antibioticbelonging to the group of ... for a minimum rmsd of the pimaricinheavy atoms led to a single type of main-chain conforma-tion (Fig. 4A, left). This is likely due in part to the particularmacrolactone ring of pimaricin, which ... polyenes are certainly the important elementscontributing to the high structural order found in the models of pimaricin, rimocidin, candidin and vacidin A. The extended polyenes constrain the polyol...

Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf

... aggregation bybinding to multiple repeats of a single-stranded DNAbinding protein (hPOT1 in humans), which in turninteracts with other proteins in the core telomerecomplex, notably TPP1, to regulate ... cells, these areassociated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete withthese proteins and induce the single-stranded ... representative of the totality of the single-stranded overhang, and which may be important for these ligands being able to differentiate telomeric quadruplexes from others in the genome.It has...

Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf

... N-termi-nal domain. Mutations in the tip of the minidomain were found to affect the stop codon speciﬁcity of the factor. The results provide new insightsinto the possible role of the C-domain in the process ... RFactivity [15]. The combination of the humanM-domain and C-domain, in the absence of the N-domain, is able to bind to the mammalian ribosome and to induce the GTPase activity of eRF3 [16].It ... minido-main of eRF1 did not change the GTPase activity of eRF3. The minidomain in the crystal structure is near the N-terminal domain, which plays a key role in stopcodon recognition. The ability of the...

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