Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3 pdf

... ubstrate of KDR kinase, i s then phosphorylated and activated, leading to the activation of p rotein kinase C (PKC), followed by the serine/ threonine kinase, Raf1 and then the threonine/tyrosine kinase, ... cloned chemokine receptor isoform named CXCR3B [34]. W e therefore studied the involvement of this receptor in the inhibition, by PF-4, of VEGF-indu ced MAP kina...

Ngày tải lên: 19/02/2014, 16:20

... To determine the in uence of the N-terminal region of TTR on the binding to thyroid hormones, the con- struction of chimeric recombinant TTRs containing variations in structure of the N-terminal ... both of which preferentially bound T3 over T4. Here, we tested that hypothesis that the structure of the N-terminal region in uence the bindin...

Ngày tải lên: 23/03/2014, 10:21

... papers the identification of linguistic structure in the aggregate analysis is based on the analysis of the pronunciation of the vowels found in the data set. In work presented in this paper the ... e.g., the first vowel in the word ’Wash- ington’ or the second vowel in the word ’thirty’. Factor analysis has shown that 3 factors are most im- portant, ex...

Ngày tải lên: 20/02/2014, 12:20

... following the first helices of domains 1 and 2, respectively. The EF-hand-like calcium site of domain 2 was described earlier, and tight binding of the ion was shown to con- tribute to the integrity of ... but rather to that of the larger maltose-bind- ing protein. This kind of protein is exemplified by the Thermus thermophilus protein, PDB entry 2B3B [28]. Th...

Ngày tải lên: 23/03/2014, 04:21

... variants of the illness are considered to be primarily autoimmune in nature [1]. The 18.5 kDa isoform of myelin basic protein (MBP) is one of the most abundant proteins in CNS myelin; MBP maintains the ... families created by the iso- tropic mixing of the TOCSY experiments [36]. The sequence-specific assignment of these spin systems was deduced from the ‘fingerpr...

Ngày tải lên: 19/02/2014, 07:20

... calling Perl routines from the Java API. Perl routines take care of the bulk of querying ency- clopedia entries to the MediaWiki software (which in turn queries the database) and efficiently parsing the ... based on the link structure of the articles); 3. computing paths in the Wikipedia categoriza- tion graph between the categories the articles are assigned...

Ngày tải lên: 20/02/2014, 12:20

... assignment. In the case of to gun down the ambiguity of to is enhanced by the ambiguity of gun, and a mistake in tagging gun will automatically lead to an incorrect tagging of to as a ... between the verb and the particle in order to optimize the perfor- mance of the tagger. 3. THE EXPERIMENT 3.1. DATA The first step in testing this...

Ngày tải lên: 20/02/2014, 21:20

... conformers. The case of the nystatin A1 is interesting regarding its interaction with the sterols and its incorporation into membranes. Unlike to filipin III, a polyene antibiotic belonging to the group of ... for a minimum rmsd of the pimaricin heavy atoms led to a single type of main-chain conforma- tion (Fig. 4A, left). This is likely due in part to the parti...

Ngày tải lên: 21/02/2014, 03:20

... aggregation by binding to multiple repeats of a single-stranded DNA binding protein (hPOT1 in humans), which in turn interacts with other proteins in the core telomere complex, notably TPP1, to regulate ... cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these prote...

Ngày tải lên: 06/03/2014, 09:22

... N-termi- nal domain. Mutations in the tip of the minidomain were found to affect the stop codon specificity of the factor. The results provide new insights into the possible role of the C-domain in the process ... RF activity [15]. The combination of the human M-domain and C-domain, in the absence of the N-domain, is able to bind to the mammali...

Ngày tải lên: 06/03/2014, 11:20