Báo cáo khoa học: The structural basis of calpain behavior p

Báo cáo khoa học: The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway pdf

... positions of the corresponding side chain, Arg220, the NADPH cofactor and the substrate analog hexose in the MUR1 structure (Fig. 11). Some of the distances between these groups are rather long ... Stereoview of the RMD monomer. The cofactor-binding domain and the substrate- binding domain are shown in aqua and light sand, respectively; the APPR portion of the cofa...

Ngày tải lên : 16/03/2014, 01:20

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Báo cáo khoa học: "The Linguistic Basis of Text Generation" doc

Ngày tải lên : 18/03/2014, 02:20

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Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc

... implications of the observed VpUcyt structure One of the most studied activities of VpU is the induc- tion of CD4 degradation in the endoplasmatic reticu- lum of infected CD4 + cells. Only the cytoplasmic domain ... calculation of preliminary protein structures [79]. radar runs in an iterative manner. The input of the ﬁrst cycle consisted of the 3D NOESY data,...

Ngày tải lên : 18/02/2014, 06:20

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Báo cáo khoa học: A structural overview of the PDI family of proteins docx

... in the structures of the isolated b¢ domain and full-length proteins. In the crystal structure of the b¢x fragment of human PDI, the C-terminal part of the x-linker turns back to contact the ... characterization of a number of PDIs has provided new insights into the structural role of this region. The structures of the full-length proteins ERp57 and yeast...

Ngày tải lên : 15/03/2014, 23:20

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Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"

... intravenous lines). The observers were not involved in the daily care of the patients, and ICU physicians were not aware of this part of the observation. As a consequence, the clinical relevance of the predefined ... for other infections, and the absence of radiological signs of pulmonary congestion might have resulted in another fluid therapy regimen. We did not sco...

Ngày tải lên : 25/10/2012, 10:39

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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... turns of the DNA double helix yields binding of the two or three NF-Y complexes on the same side of the DNA. Conservation of spacing is required for optimal promoter activity because changing the ... site in activating the Cdc2 promoter. Binding of the activating E2Fs during the cell cycle to the promoter alternates with binding of E2F4 in quies- cent cells. Mu...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: intersubunit interactions during virus assembly doc

... helix 4 of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix 7 of the NTD of the neighboring subunit. The NTD–CTD ... model of the NTD hexamer from MLV, the superimposed model of the NTD hexamer from HIV-1, the high-resolution X-ray model of the modiﬁed CA hexamer from HI...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: designing inhibitors of capsid assembly ppt

... which corresponds to the a-helix 7 of NTD. This region is important for the formation of CA hexamers [6]; therefore, this peptide could inhibit the formation of the hexamers, and assembly of the HIV-1 ... the X-ray structure of the nonmu- tated-CTD–CAI complex [28] (Fig. 2A, main panel). The aromatic moiety of Phe3, together with Leu6 and Ile1, are the residues...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx

... Furthermore, the pro-peptide of GDF-8 impairs interaction of the mature part with its receptors [16]. In the case of BMP-9, the pro-peptide appears not to alter signiﬁcantly the activity of the mature ... biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor b (TGFb) ⁄ BLP superfamily. The role...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

... present for the last four residues at the C-terminus. The stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regions ... inhibitors of hACMSD, of which 1,3-dihydroxyacetonephosphate (DHAP) was the most potent and was therefore selected for our structural investigation. Our results...

Ngày tải lên : 18/02/2014, 06:20

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Báo cáo khoa học: The structural basis of calpain behavior pptx

Báo cáo khoa học: The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway pdf

Báo cáo khoa học: "The Linguistic Basis of Text Generation" doc