Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide pdf
Báo cáo khoa học: P NMR studies of energy metabolism in xanthosine5¢-monophosphate overproducing Corynebacterium ammoniagenes pot
... ratios (glu/glc) in the medium were adjusted to a molar ratio of 0.31. The 31 P NMR illustrated the two distinct phases of the cellular energetic status due to the availability of the sub- strates from the medium. ... supplementation of the carbon skeleton and the tricarboxylic acid (TCA) cycle for maximization of ATP production was discussed. However, direct est...
Ngày tải lên: 23/03/2014, 17:22
Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc
... conditions that would allow high-resolution NMR studies of MBP in an environ- ment most closely mimicking the native myelin sheath. Although there have been previous NMR studies of other MBP-derived polypeptides ... shows the electrostatic surface charge of residues P5¢ to P16¢ of the proposed structures of FF 2 from two orthogonal view angles. The partitioning of...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity doc
... bond between the hydrogen of OH9 (H O 9) and the oxygen of OH7 (O H 7) which can contribute to the stabilization of the C7–C9 region of the macrolide. Structural analysis of nystatin A1 The spectral ... However, for the C1–C7 segment, the two hydroxyl groups on C3 and C5 are, respectively, hydrogen bonded with the CO groups of C1 and C7 in the majority of th...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
... vitamin A-deficient rats. In the liver of rats with hypervitaminosis the results showed a decrease in theamountofp53andanincreaseofthec-Jun .The gureshows that the expression of p53 is time course dependent. ... was analyzed by the Levene test; in those cases in which the variances were unequal, the data were adequately transformed before the ANOVA . The null hypothesis was...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... iden- tified as the major and the minor forms of the holo- ACP structure, on the basis of their percentage contri- butions (65% and 35%, respectively) to the overall structure of the protein. The structures ... estimated on the basis of the linear regression of the fraction number of the molecular mass markers cytochrome c (CyC), carbonic anhydrase (CA), and B...
Ngày tải lên: 16/03/2014, 10:20
Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... the projection of the tilt of the z axis on the x¢,y¢ plane (defined direction of tilt of z and the x¢ axis), and j % a + c defines the location of the rhombic (x, y) axes. The orientation of the ... in the 1 H NMR data of Pe HbO 2 . The static structure of neither WT nor rWT metMb would allow the TyrE7 ring reorientation without significant distortion...
Ngày tải lên: 23/03/2014, 17:22
Báo cáo khoa học: An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein pot
... the ATP7B protein that the second metal-binding domain constitutes the pre- ferred one for the uptake of the first metal ion by the ATPase from the chaperone, as a result of the specific- ity of ... preferential interaction of the chaperone with the second domain seems unlikely also in the case of ATP7B. The selectiv- ity, if any, for the interaction of one...
Ngày tải lên: 30/03/2014, 15:20
Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx
... mice [28]. The instability of DA at the neutral pH of the cytosol causes the forma- tion of toxic aminochromes, and these species are not formed when DA is protonated at the acidic pH of the storage ... counter. Values are the mean of six replicates. The specific uptake was determined by subtracting the uptake counts in the absence of inhibitor from the uptake...
Ngày tải lên: 14/02/2014, 21:20
Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obes- ity and related metabolic diseases, and discuss whether these ANGPTLs could be targets for the prevention and treatment of these conditions. Suppression ... adipose tissue of ANGPTL2 null mice compared with that of wild-type mice [15]. These results raise the possibility that blocking ANGPTL2 signaling simultaneously su...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... observation). In the ternary complex, the histone H3 peptide binds in a deep chan- nel that divides a pair of acidic lobes, one of which is composed of residues from the SET-I region and the other of residues ... present. This is because the con- struct used to determine the structure of the MLL1 SET domain lacks the evolutionarily conserved Win motif in the region...
Ngày tải lên: 16/02/2014, 14:20