Báo cáo khoa học: Metabonomics in pharmaceutical R & D doc

... under way to investigate the reporting needs and standardization of reporting arrangements for metabonomics studies. The Standard Metabolic Reporting Structures group (http:// www.smrsgroup.org) ... lower left quad- rant and in the corresponding loadings plot, this region indicated that NMR peaks from 2-AA (2-aminoadipate) were important, and thus this is a biomarker of the hydrazine-indu...

Ngày tải lên: 23/03/2014, 09:21

... paper we presented a new method for unsu- pervised learning of dependency parsers. In con- trast to previous approaches that constrain model parameters, we constrain model posteriors. Our approach ... outperforms the standard EM algorithm and a discounting Dirichlet prior. We have several ideas for further improving our constraints, such as: taking into account the direc- tionality of the e...

Ngày tải lên: 07/03/2014, 22:20

... cysteine and thrionine transporter. D- Serine Selected references Occurrence Enriched in the mammalian brain and in some insects [24,30] Target receptor NMDAR [10,22,93] Actions Modulates NMDAR transmission, ... MK-801 NMDA +DNQ DsdA Fig. 2. The role of endogenous D- serine in NMDAR-elicited neurotoxicity. The removal of D- serine by D- serine deaminase enzyme (DsdA) completely prev...

Ngày tải lên: 30/03/2014, 04:20

... All residue swapping procedures therefore involved the GAF B regions. We hoped to prototypi- cally identify individual residues or narrow regions in the cyaB1 and rPDE2 tandem GAF domains that dis- criminate ... mPDE2 GAF domain crystal structure [12]. Of the 12 amino acids identified as interaction partners for cGMP, only four bind directly to the pur- ine moiety and are thus potentially in...

Ngày tải lên: 19/02/2014, 02:20

... Kremer, W., Maurer, T., Doker, R. & Kalbitzer, H .R. (2000) Pressure-induced local unfolding of the Ras binding domain of RalGDS. Nat. Struct. Biol. 7, 547–550. 50. Suarez, M.C., Lehrer, S.S. & ... of change induced by pressure. Changes in secondary structure upon dissociation and denaturation To further confirm the urea-induced changes in secondary structure, we analyzed the UV C...

Ngày tải lên: 19/02/2014, 12:20

... operation act performance performance action act deed operation performance action act deed deed act deed doing act action deed act action deed instrument act proceeding act proceeding action ... thesaurus is then considered; this involves a method for defining the meanings or uses of words, and a procedure for classifying them. It is suggested that word uses may be defined in t...

Ngày tải lên: 19/02/2014, 19:20

... fold regions needed for the handshake contacts is essential. Their N-termini are required for interaction with neighbouring DNA while the C-termini provide docking domains for internucleosomal interactions. ... example, during radiation-induced DNA damage or other events lead- ing to double stranded breaks (DSBs) in DNA, a his- tone variant present at the DNA damage point may act as a marke...

Ngày tải lên: 20/02/2014, 02:22

... m M 2,4-dinitrophenolhydrazine in 2 M HCl, incu- bated at room temperature and neutralized. The derivatized proteins were separated by SDS/PAGE, transferred to a nitrocellulose membrane and treated as previous ... fixed by immersion in 2% paraformaldehyde/ 0.2% glutaraldehyde in NaCl/P i for 2 h at room tempera- ture, contrasted with 1% uranyl acetate. The resulting material was dehydrat...

Ngày tải lên: 20/02/2014, 11:20

... system, developed in the TALK project in cooperation between several academic and industrial partners, employs the Information State Update paradigm, extended to model collab- orative problem solving, ... and a set of XSLT trans- formations to yield the output strings. Output in German and English is produced by accessing dif- ferent dictionaries in a uniform way. In order to facili...

Ngày tải lên: 20/02/2014, 12:20

... would never be found in a writ- ten text. extended in order to maintain a coherent discourse structure for the modelling of the producer. Thus rhetorical relations describing planning processes ... combined D[ ROM, I newly generated sentence is incorporated in the cur- rent discourse structure. Although the production took place under a cer- tain amount of pressure, the righ...

Ngày tải lên: 20/02/2014, 18:20