Báo cáo khoa học: PACSIN 1 forms tetramers via its N-terminal F-BAR domain pdf

... article. PACSIN 1 oligomerization A. Halbach et al.782 FEBS Journal 274 (2007) 773–782 ª 2007 The Authors Journal compilation ª 2007 FEBS PACSIN 1 forms tetramers via its N-terminal F-BAR domain Arndt ... of PACSIN 1 with an N-terminal F-BAR domain and a C-terminal SH3 domain. The F-BAR domain was formerly known as theCDC15-NT domain, and includes a con-served region, also named the FCH domain, and ... arranged PACSIN moleculesbind to each other via a large globular domain and form a barrel-likestructure. Together, these results demonstrate that the N-terminal F-BAR domain of PACSIN 1 forms...

Báo cáo khoa học: "Dynamic Nonlocal Language Modeling via Hierarchical Topic-Based Adaptation" pdf

... X ~ - X X Z - X* X Z* -* 1 x - X ~z _ x x z 15 -NN e z ~e z - 206 19 5 19 2 ( -10 %) 460 405 389(-33%) 202 444 19 3 394 19 2 390 19 6 411 Table 1: Perplexity results for topic ... trigram model in 17 0 Case 1: fnode (Wl) ~ 0 P root (w2lwl) , ~1 fnode (w21wl) "?node (Wl) + ,~2/~node (W,.) Pnode (I/] 211 1) = -~ (1 ) ~1 ~2) Pp t(node) (~ 21~ ) ~.ode (~I) Pnode ... are used: one 17 1 It is at least on the Serb side a real setback to the peace a3 cA ~ o.~ o Topi¢ ID 0. 016 0. 014 "~ 0. 012 ,.~ 0. 01 o.l~le o.oo4 o ' I t ~11 P~ce~c I history)...

Báo cáo khoa học: Regulation of ascidian Rel by its alternative splice variant pdf

... Hokkaido University,Sapporo 060-0 812 , Japan.Fax: + 81 11 706 4900, Tel.: + 81 11 706 3754,E-mail: yoko@pharm.hokudai.ac.jpAbbreviations: RHD, Rel homology domain; IKK, IjBkinase;GST, glutathione ... 5¢-TTTCGGTTTGTAATGTTAGT-3¢ (As-rel2bp 16 56 16 47); genome reverse R3 primer, 5¢-GAATACGAACCCAAACAA-3¢ (As-rel2 bp 211 7– 210 0); genomereverse R4 primer, 5¢-TGTCTTCATGTGGGACAA-3¢(As-rel1 bp 14 41 14 34)] using an Expand ... 5¢-CTGCTGGATAGATGATGC-3¢ (As-rel2 bp 9 41 958); genome forward F4 primer,5¢-ACTTATTTTTCTCGCACA-3¢ (As-rel2 bp 17 00 17 17);genome reverse R1 primer, 5¢-TCTGATTGAGGTTAGTGG-3¢ (As-rel2 bp 15 80 15 63); genome reverse...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... DE- 81 ﬁlter paperS103Y 112 R207 /19 9K173 /16 5G145/D137D142 /13 4E1 41/ 133L75/67D2 01/ 193G77/69G197 /18 9G145/D137ABFig. 2. Superposition of PRTFDC1 with HPRT-ImmGP (Protein Data Bank code: 1BZY) ... 0.9 2.9 · 10 6± 1. 0 · 10 6 (10 0%)GuaninePRTFDC1 36 .1 ± 14 .3 2.9 ± 0.7 1. 36 ± 0.34 3.9 · 10 4± 9.3 · 10 3(0.09%)HPRT 9.9 ± 0.2 899 ± 11 7 406 ± 53 4.5 · 10 7± 1. 0 · 10 7 (10 0%)M. Welin et ... 40 60 80 10 0 12 0S/V200 250[Hx] (µM)0 50 10 0 15 0 200 250[Hx] (µM)[G] (µM)[G] (µM)0 12 010 0806040200 10 20 30 40 50 602.0 12 002520 15 10 50 10 008006004002000 1. 5 1. 00.50.0Fig....

Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc

... B-II: 0 .1% SDS, 1% Triton X -10 0, 2 mmEDTA, 500 mm NaCl, 20 mm Tris ⁄ HCl, pH 8; B-III:0.25 m LiCl, 1% Nonidet P-40, 1% sodium deoxycholate,1mm EDTA, 10 mm Tris ⁄ HCl, pH 8; B-IV: 1 mmEDTA ,10 mm ... containing 1% SDS, 10 mmEDTA, 50 mm Tris ⁄ HCl, pH 8. Lysates were centrifuged at 14 000 g for 10 min at 4 °C, and the supernatant obtainedwas diluted 10 -fold using IP buffer [0. 01% SDS, 1. 1%Triton ... After 1 h of incubation at 4 °C, the immunoprecipi-tates were centrifuged (at 14 000 g, 10 min, 4 °C) andwashed twice each with four buffers (B-I: 0 .1% SDS, 1% Triton X -10 0, 2 mm EDTA, 15 0 mm...

Tài liệu Báo cáo khoa học: Caveolin-1 inﬂuences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells docx

... 7 8 910 111 213 PDIP2X7R-CopFlotillin -1 BTriton X -10 0soluble insolubleP2X7RCav -1 Flotillin -1 T1TfRFig. 2. (A) Solubility of Caveolin -1, Flo -1 and P2X7receptor in Triton X -10 0. E10 ... Caveolin -1 protein in E10cells, we designed two different shRNAs targetedto the mouse Caveolin -1 mRNA. Figure 6B showsCav -1 12345678 910 111 213 14P2X7RFlotillin -1 -CopPDITfR 1 2 3 4 56789Cav -1 P2X7RFlotillin -1 -CopPDITfRABFig. ... Res 76, 653–6 61. 18 Vial C & Evans RJ (2005) Disruption of lipid raftsinhibits P2X1 receptor-mediated currents and arterialvasoconstriction. J Biol Chem 280, 30705–30 711 . 19 Kim M, Jiang...

Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx

... 30408Rsym 15 .0 A˚– resolution limit (%) 11 .4 (38 .1* )Completeness (%) 10 0 (10 0*)I ⁄ rI 6.0 (1. 9*)Wilson B (A˚2) 11 .57Multiplicity 3.7Rwork(%) 16 .0Rfree(%) 19 .3*Outer shell: 1. 9 1. 8 A˚Structure ... peptidase (EC 3.4. 21 ); protein-ase K (EC 3.4. 21. 64); Vibrio sp. peptidase(EC 3.4. 21 ).(Received 7 September 2005, revised 25October 2005, accepted 31 October 2005)doi :10 .11 11/ j .17 42-4658.2005.05040.xProteins ... intramolecular quenching.Biochemistry 31, 6 011 –6 018 . 17 Gron H & Breddam K (19 92) Interdependency of thebinding subsites in subtilisin. Biochemistry 31, 8967–89 71. 18 Larsen AN, Moe E, Helland R,...

Tài liệu Báo cáo khoa học: Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter docx

... via the bipartite Ets-AP1 element. Mol. Endocrinol. 11 , 11 29 11 44.40. Robinson, M.J. & Cobb, M.H. (19 97) Mitogen-activated proteinkinase pathways. Curr. Opin. Cell Biol. 9, 18 0 18 6. 41. ... Guenet,J.L.,Carle,G.F.&Wagner,E.F. (19 97)Structureandchromo-somal assignment of the mouse fra -1 gene, and its exclusion as acandidate gene for oc (osteosclerosis). Oncogene 15 , 11 71 11 78.57. Nutt, J.E. & Lunec, J. (19 96) ... melanoma cells by the N-terminal domain of adenovirusE1A 12 S protein. J. Cell Biochem. 85, 54– 71. Ó FEBS 2003 Fra -1 and the 2G SNP (Eur. J. Biochem. 270) 4225Fra -1 targets the AP -1 site/2G single...

Báo cáo khoa học: Nck-1 selectively modulates eIF2aSer51 phosphorylation by a subset of eIF2a-kinases docx

... St., Rm W 315 , Montreal,QC, Canada H3A 2B2Fax: +1 514 398 3923Tel: +1 514 398 5844E-mail: louise.larose@mcgill.ca(Received 16 August 2007, accepted 19 September 2007)doi :10 .11 11/ j .17 42-4658.2007.0 611 0.xPhosphorylation ... eIF2α(Vector =10 0%)020406080 10 0 12 0 14 0 16 0% of peIF2α / total eIF2α(PKR + Vector =10 0%)-+-+peIF2αSer 51 eIF2αNckWTGCN2ΔNck -1 12 34WT + p425GAL1WT + p425GAL1-Nck -1 GCN2Δ+ p425GAL1Glucose ... gÆL )1 ),magnesium sulfate (heptahydrate) (0 .10 gÆL )1 ), calciumchloride (0 .15 gÆL )1 ), sodium bicarbonate (1. 2 gÆL )1 ),supplemented with 10 % dialyzed fetal bovine serum(Invitrogen) and 1% ...

Báo cáo khoa học: Isoquinoline-1,3,4-trione and its derivatives attenuate b-amyloid-induced apoptosis of neuronal cells pdf

... 0.006 0.2 01 ± 0.006 0 .13 6 ± 0. 014 1. 122 ± 0.043 1. 640 ± 0.089Compound 4 0.657 ± 0.086 0.064 ± 0.004 0 .14 8 ± 0.0 31 0 .11 3 ± 0. 016 2.360 ± 0 .15 5 1. 811 ± 0. 315 Compound 5 0.303 ± 0.0 51 0.055 ± 0.004 ... 1. 529 ± 0.2 41 0 .14 9 ± 0. 015 0.474 ± 0.083 0.386 ± 0.034 1. 913 ± 0 .15 2 1. 574 ± 0.284Compound 2 0.537 ± 0.035 0 .11 3 ± 0. 011 0 .13 7 ± 0.006 0. 218 ± 0.024 0.835 ± 0. 016 1. 300 ± 0 .12 7Compound 3 0.859 ... conferredabde fcA 12 0B 10 0806040200–––20Aβ25−35 (μM)Ac-DEVD-CHO (μM)compound 1 (μM)20 205220 20 20 20 20 20 20***** 1 10––30 20 10 5 1 ––––––––C35302520 15 10 50Aβ25−35Ac-DEVD-CHO...

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