Báo cáo khoa học: The intrinsic structure of glucose transporter isoforms Glut1 and Glut3 regulates their differential distribution to detergent-resistant membrane domains in nonpolarized mammalian cells potx
... replacement of neither the C-terminal nor the N-terminal amino acids of Glut1 domains with the corresponding amino acids of Glut3 had any significant effect on the distribution of Glut1 in CHO-K1 cells ... between Glut1 and Glut3 are the N-terminus and the C-terminus, and the large intracellular loop between transmembrane domains 6 and 7. As a...
Ngày tải lên: 23/03/2014, 09:20
... mechanism is still incomplete. In light of the reported ACMSD upregulation in the liver of streptozotocin-induced diabetic rats and the suppres- sion of such elevation following insulin injection [21,22], ... homeostasis. Indeed, the enzyme stands at a branch point of the tryptophan to NAD pathway, and deter- mines the final fate of the amino acid, i.e. transf...
Ngày tải lên: 18/02/2014, 06:20
... an important role in building the Greek key structure and in designing the metal binding site and the active cavity of the system. The analysis of the H-bonds in the present structure has been ... assigned by the analysis of the H NHB experiment. In each subunit the metal ions were included by allowing copper t o bind to Ne2 of His48 and His120...
Ngày tải lên: 21/02/2014, 03:20
Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
... protein stain- ing. The ratio of the upper protein band to the lower one was estimated to be approximately 2 by densitometric scanning. Activity staining of the enzyme indicated that the upper band reconstituted ... a D in the N-terminal and by three than b D in the C-terminal, respectively. In the final structure, all residues of the a chain (Met1–Glu555),...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: The crystal structure of NlpI A prokaryotic tetratricopeptide repeat protein with a globular fold potx
... FEBS the full-length HOP, they act to facilitate the assembly of multichaperone regulatory complexes. The struc- tural independence of these TPR domains, and the presence of independent ligand-binding ... that they are discrete domains. TPR domains, or even subsets of TPRs within a domain [12], are often studied independently. In the course of a wider effort towar...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
... changes in the purified lipid A and in the lipid A moiety of intact LPS were reported [4]. The binding of LPS to oxyHb results in the oxidation of theHbtometHbandhemichrome[3].Incontrasttothe lack of ... cross-linked hemoglobin, both smooth LPSs produced a rate of oxidation faster than the corresponding rough LPSs, indicating the importance of the binding o...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx
... clear that the plant protein is not able to bind metal cations in the conformation found in the crystal structure. Neither the first nor the other domains are able to coordinate cations in these regions, ... side. In the case of Anx24(Ca32), a number of hydrophobic and aromatic residues are found on the surface of the mem- brane-binding side. When compari...
Ngày tải lên: 17/03/2014, 03:20
Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf
... following the first helices of domains 1 and 2, respectively. The EF-hand-like calcium site of domain 2 was described earlier, and tight binding of the ion was shown to con- tribute to the integrity of ... but rather to that of the larger maltose-bind- ing protein. This kind of protein is exemplified by the Thermus thermophilus protein, PDB entry 2B3B [28]....
Ngày tải lên: 23/03/2014, 04:21
Báo cáo khoa học: The crystal structure of a xyloglucan-specific endo-b-1,4glucanase from Geotrichum sp. M128 xyloglucanase reveals a key amino acid residue for substrate specificity potx
... end of the active site cleft, which accounts for its exo mode of action. In contrast, XEG lacks a corresponding loop at this site, thereby allowing binding to the middle of the main chain of the ... corresponding to the exo-loop of OXG-RCBH. The coordinates and structure factors have been deposited in the Protein Data Bank (PDB) (accession code 3A0F). The...
Ngày tải lên: 23/03/2014, 05:22
Báo cáo khoa học: The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) pdf
... in host response events, including the participation of host CypA in binding the capsid protein Gag of HIV-1 during infec- tion in humans and packaging into HIV virions, and the association of ... partners: PPIL1 binds to the SNW domain-containing protein 1 (SKIP), and CypH binds to the small ribonucleoprotein Prp4 [18,31–33]. Interestingly, in both of thes...
Ngày tải lên: 23/03/2014, 07:20