Báo cáo khoa học: Protein kinase Ce: the mitochondria-mediated signaling pathway pot

... downstream of the signaling pathways, branches into two pathways: the mitochondria-inde- pendent path way and the mitochondria-mediated pathway. The former pathway involves the proteolytic activation ... mitochondria-mediated apoptosis and protein kinase Ce. Therefore, by focusing on these relation- ships, in particular the anti-apoptotic effects of protein kinase...

Ngày tải lên: 23/03/2014, 07:20

... of brain regions. There are two types of LTP in the hippocampus [15]; one is LTP in the pathway from the Schaffer collaterals to CA1 (SC- CA1) and the other is the pathway from the mossy fibers ... e-subspecies of protein kinase C in the rat brain; presynaptic localization of the e-subspecies. Brain Res 607, 241–248. 5 Tanaka C & Nishizuka Y (1994) The protein...

Ngày tải lên: 23/03/2014, 07:20

... difficulties entering the S phase. The reason for the accumulation of cells in the G 1 phase may be due to the slightly lower kinase activity of the (S > A) 6 mutant Rio1p kinase during the G 1 phase ... several pathways in yeast (as may be deduced from the fact that two orthologues occur in higher eukaryotes) [13]. The biological role of Rio1p or even the pathways i...

Ngày tải lên: 18/02/2014, 16:20

... secreted from the cell or localized to the ER lumen, and membrane proteins, such as those in the plasma membrane or in other organelles of the secretory pathway. Soluble proteins cross the membrane ... detergent. Membrane protein integration During the synthesis of a membrane protein, hydro- phobic TM segments move from the aqueous interior of the channel through the lat...

Ngày tải lên: 07/03/2014, 06:20

... separately from the other TRs, because they signif- icantly outnumber the other types of repeats, and having them in the same group would obscure the effect related to the other repeats. The amino ... cytoplasmic proteins were predicted to be the most structured, whereas in eukaryotes, the most struc- tured portion of the repeats was found in the membrane proteins. Our stu...

Ngày tải lên: 15/03/2014, 11:20

... confirm this hypothesis, the influence of the concentrations of NADP + and MEP 5 ,the substrates of the reverse reaction, and of NADPH and DXP 3, the products of the reaction, on the total amount ... NADPH-dependent reduction of the oxo group to give the final product. In the reactions catalyzed by the two enzymes, the ketol-acid and the DXP isomero- reductase, the for...

Ngày tải lên: 21/02/2014, 03:20

... catalytically com- petent state. A further concern is whether the protein kinase activity of DNA-PKcs is really associated with the EJ reaction in the context of protein DNA coaggregative networks. ... of nucleoproteins in human cellular fractions and that they mediate the separation of large protein DNA aggregates from aque- ous solution. The interaction among the aggregati...

Ngày tải lên: 19/02/2014, 06:20

... of other protein kinases masking the PKA-catalysed part. Indeed, protein kinases other than PKA, including tyrosine kinases, have been demonstrated to directly phosphorylate GIRK1 [12]. The observation ... previously [18]. To assess the role of the S ⁄ Ts in the regulation of GIRK1 via PKA in a manner that is unbiased by the eventual contributions of the other subunits in a...

Ngày tải lên: 07/03/2014, 00:20

... Tec transcription via the NF-jB signaling pathway. These findings provide further insight into the transcriptional regulation of the TFKs and the role of NF-jB signaling in lymphocyte development and the immune ... Jiangsu, China Introduction The tyrosine kinase expressed in hepatocellular carci- noma (Tec) is a non-receptor tyrosine kinase belonging to the Tec family of...

Ngày tải lên: 07/03/2014, 00:20

... Gal-Jun(1±223) contains the Gal4 DNA-binding domain fused to the transactivation domain o f Jun. The pCMVnlac encodes the sequences for the b-galactosidase gene under the control o f the cytomegalovirus ... [37]. The association of Ras-GRF2 with dematin, an actin binding and bundling protein, provides a potential coupling mechan ism between Ras signaling a nd the a ctin c...

Ngày tải lên: 17/03/2014, 11:20