Báo cáo khoa học: Protein kinase Ce: function in neurons pot

... of PKCe may in uence the function of actin binding proteins, leading to actin rearrange- ment and neurite induction. In addition, the binding of PKCe to PIP 2 may contribute towards inhibition ... coiled-coil- containing protein kinase (ROCK), indicating that attenuation of the RhoA-ROCK pathway is involved in the process [9]. Additionally, activation of Cdc42 is implicated in PK...

Ngày tải lên: 23/03/2014, 07:20

... (DNA-PK), which is fundamentally involved in this pathway, is a nuclear serine ⁄ threonine protein kinase, and is a member of the PI3K-related kinase subfamily of protein kinases. DNA-PK is activated ... focusing on these relation- ships, in particular the anti-apoptotic effects of protein kinase Ce on mitochondrial function, we highlight the importance and significance of pro...

Ngày tải lên: 23/03/2014, 07:20

... aprotinin, leupeptin and pepstatin, twice in kinase buffer, and used for in vitro kinase assays. In vitro kinase assays Recombinant human protein kinase CK2 holoenzyme (0.5 U, corresponding to ... G 1 phase [11]. Keywords atypical protein kinase; casein kinase 2 substrate; cell-cycle phase-dependent degradation; protein protein interactions; Rio1 protein kinase 2 1...

Ngày tải lên: 18/02/2014, 16:20

... dominant negative protein kinase C; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; JNK, c-Jun N-terminal kinase; PKC, protein kinase C; NaCl ⁄ P i , phosphate- buffered saline; nPKC, novel protein ... expressed in L-MAT, a human lymphoblastic T-cell line. In this report, we provide the following evidence that the protein kinase C (PKC)h activity is func- tionally involved...

Ngày tải lên: 23/03/2014, 13:20

... shown to bind to and inhibit the ser- ine–threonine protein phosphatase calcineurin [5]. The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is highly ... chronic in ammation [6–8]. There are data showing decreased calcineurin activity in AD, and other studies have shown that calcineurin inhibition results in tau phos- phorylation on...

Ngày tải lên: 16/03/2014, 11:20

... diverge. In 10a-3, the beginning of ADV is most plausibly interpreted with respect to the TF. The end of ADV in turn provides an anaphoric interpretation point for RT 3. Since ET 3 is interpreted ... processing clause 2 Applying the FMH again, RT 2 is the new TF going into clause 3. Examples 7a and 7b here diverge in what subsequently happens to the TF. In 7a, RT 3 can be anaph...

Ngày tải lên: 17/03/2014, 20:20

... pronominal in Japanese, and the (unstressed) overt pronoun in English. The resulting constraint complements the original Centering, accounting for its apparent violations and providing a ... marked on the verb inflection. The basic Centering role in Japanese can be obtained by changing the word pronoun to zero pronominal in (1) (Kameyama 1985). In the following discourse frag...

Ngày tải lên: 31/03/2014, 17:20

... from referring anaphors in that they cannot be questioned (e.g., *When what comes to trucks ?). 3 Synchronising Units The domain which contains potential antecedents is not given in syntactic ... paired with an A and they jointly form a Synchronising Unit (SU). In longer turns, each main clause functions as a separate unit along with its sub- ordinate clauses. Single I's c...

Ngày tải lên: 31/03/2014, 21:20

... calmodulin; ClpC, caseinolytic protease C; Cpn, chaperonin; FNR, ferredoxin-NADP + -oxidoreductase; Hip, Hsp70-interacting protein; Hop, Hsp70/Hsp90-organizing protein; Hsp, heat shock protein; IEM, ... domains are degenerate 34-amino acid repeats forming anti-parallel a-helices known to be involved in an array of protein protein interactions (generally with non-TPR proteins) [41]. Bo...

Ngày tải lên: 07/03/2014, 03:20

... membrane. The proteins carrying biotin were detected by the reaction with alkaline phosphatase-conjugated avidin: lane 1, intact PC; lane 2, PC- (CT + BCCP). Ó FEBS 2004 Protein engineering of pyruvate ... engineered in such a way as to divide the protein into two at the boundary of the BC and CT domains (Fig. 1). The properties of the resulting two proteins, PC-(BC) and PC-(CT + BCCP),...

Ngày tải lên: 16/03/2014, 16:20