Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
... 3. Autocatalytic cleavage of the mutants S15 3A -PCSK9, Q19 0A -PCSK9, R19 4A -PCSK9, D20 4A -PCSK9, K22 2A -PCSK9, R23 7A -PCSK9, D23 8A -PCSK9, D37 4A -PCSK9, C37 5A -PCSK9, S37 6A -PCSK9, T37 7A -PCSK9, C37 8A -PCSK9 ... other vertebrates. In conclusion, there is a single, large, evolutionarily conserved protrusion on the surface of the catalytic domain of...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
... induce a conforma- tional transition that modifies the intra-subunit interaction between the regulatory and the catalytic domains. This interaction is followed by the formation of a catalytically activated ... surface plasmon resonance analysis, and the rate of phosphorylation of Ser16 by cAMP- dependent protein kinase. Comparison of the inhibitory properties of the...
Ngày tải lên: 17/03/2014, 09:20
Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx
... states along the activation pathway, and not reaching the active photointermedi- ate, Meta II. The kinetic parameters of formation and disappearance of these altered photointermediates were evaluated. ... to the reduced degree of Gt activation observed. In terms of the thermal stability, the active conformation of the G51V mutant was less stable than the active confo...
Ngày tải lên: 22/03/2014, 16:20
Báo cáo khoa học: "What is the Minimal Set of Fragments that Achieves Maximal Parse Accuracy?" potx
... in the fragment frontiers to 12 and a restriction of the depth of unlexicalized fragments to 6. No other constraints were warranted. There is an important question why maximal parse accuracy ... quarter of all nonempty subjects in the WSJ appear in such a configuration. In order to isolate the contribution of nonheadword dependencies to the parse accuracy, we eliminate...
Ngày tải lên: 23/03/2014, 19:20
Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... influence the parameters, and the fractional contribution of the additional lifetime was close to zero. Figure 5 shows the typical time-dependent donor decays for the D 1 –CFP bearing donor alone and ... (two each) from the arginine-rich epitope (217RRRRKR222) of the third intra- cellular loop were exchanged (D 2 R1: 217AARRKR222, D 2 R2: 217AAAAKR222, D 2 R3: 217AAAAAA222),...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khoa học: Investigations into the ability of an oblique a-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide pot
... centrally located in the apolar face of the AP1 a- helix, and previous studies have shown that similarly located glutamate residues are important for the antimicrobial action of other a- AMPs also predicted ... x n are the molar fractions of the components and p is the surface pressure. These data were then recorded as the variation of DG Mix with monolayer surface p...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: "Investigations on Word Senses and Word Usages" ppt
... Erk University of Texas at Austin katrin.erk@mail.utexas.edu Diana McCarthy University of Sussex dianam@sussex.ac.uk Nicholas Gaylord University of Texas at Austin nlgaylord@mail.utexas.edu Abstract The vast ... WSsim annotations. We therefore repeated the analysis for Usim on the subset of data in WSsim and provide the correlation in the middle section of table 5. The...
Ngày tải lên: 08/03/2014, 00:20
Báo cáo khoa học: Studies on structure–function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway ppt
... molecular mass standards. Small angle X-ray solution scattering with synchrotron radiation. Data were collected on the X33 camera of the European Molecular Biology Laboratory outstation at Hasylab at ... Under all conditions used, the reaction rate is directly proportional to the EcIPDC concentration and independent of the concentration of the auxiliary enzyme, confirming t...
Ngày tải lên: 08/03/2014, 02:20
Báo cáo khoa học: "Completing on the partial basis parses of ill-formed sentences of discourse information" docx
... complete parses, it reflects the grammar rules of the parser, and a matching pattern with a part of speech rather than an actual word on one side can be regarded as a relaxation rule, in the sense ... PP AJ N PP V PP what information is available about the AS/400 system. Candidates AJ N V AJ AJ DET N N for the POS AV AV of each word PN PP Phrases what informati...
Ngày tải lên: 08/03/2014, 07:20
Báo cáo khoa học: "Investigations on Event-Based Summarization" pptx
... triples. After analysis of triples they connect nodes (words or phrases) by way of se- mantic relationships. Yoshioka and Haraguchi (2004) adopt a similar approach to build a map, but they regard ... as the nodes of the map. After construction of a map representation for documents, Vanderwende et al. (2004), and Yo- shioka and Haraguchi (2004) all employ PageR- ank algo...
Ngày tải lên: 17/03/2014, 04:20