Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx

... FEBS 29 55 Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20 S proteasome Gustavo M. Silva 1 ,2 , Luis E.S. Netto 2 , Karen F. Discola 2 , Gilberto M. ... SG (20 01) Inactivation of human G. M. Silva et al. Cysteinyl-based modification of the 20 S proteasome FEBS Journal 27 5 (20 08) 29 42 29 55 ª...

Ngày tải lên: 23/03/2014, 07:20

... impor- tant roles in maintaining immune homeostasis and pre- venting autoimmunity. These regulatory cells can either develop in the thymus or differentiate in the periphery. The central role of cytokines ... IFN- Fig. 2. Itk in uences the balance of conven- tional and innate T-cell lineages. In the absence of Itk, there is a reduction of con- ventional CD4 +...

Ngày tải lên: 28/03/2014, 22:21

... membrane maintains the cytosolic and mitochondrial compartments in equilibrium. We were interested in investigating whether in the fibroblasts of the two TK2 patients the operation of the network ... efficiency in Ca and Pa cells (Fig. 2A), con- firming the involvement of TK2 in the phosphorylation of thymidine in both cell lines inferred above (Table 1) f...

Ngày tải lên: 30/03/2014, 02:20

... previously [21 25 ], and DG D ° values in the presence of these osmolytes are given in Table 1. How- ever, DG D ° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethyl- glycine ... backbone and the osmolytes leading to the preferential hydration of the protein domain is the driving force of protein stabiliza- tion or fo...

Ngày tải lên: 07/03/2014, 00:20

... and SCL-MI Each labeled dataset was split into a training set of 1600 instances and a test set of 400 instances. All the experiments use a classifier trained on the train- ing set of one domain ... bars, the first letter is the source domain and the second letter is the target domain. The thick horizontal bars are the accura- cies of the in- domain classifiers fo...

Ngày tải lên: 08/03/2014, 02:21

... respect to the positioning of the ligands and the conformations of the residues lining the binding site (Table 2) . In an initial comparison of the ligand positions of tetracycline, dox and atc in TetR, ... increased coordinate errors during the refinement of the atomic positions and hence a less accurate ligand positioning in site II. Accordingly, the...

Ngày tải lên: 16/03/2014, 00:20

... 16.8 StB-Y31 23 .7 25 .7 G4R 20 .9 25 .9 Prefibrillar StB-wt 25 .3 24 .5 StB-Y31 24 .7 27 .0 G4R 26 .7 26 .9 Pore formation of stefin B into lipid membranes S. Rabzelj et al. 24 58 FEBS Journal 27 5 (20 08) 24 55 24 66 ... stefin B: in uence of pH and TFE on fibril growth and morphology. Amyloid 14, 23 7 24 7. 32 Gorbenko GP & Kinnunen PK (20 06) The role of lip...

Ngày tải lên: 30/03/2014, 04:20

... of the active site was better in the protein bear- ing the N2 domain than in the protein bearing the Nc domain. Thus, the accessibility of the active site in the N2 proteins was independent of ... of the water–lipid interface. Also, both the N-terminal and C-terminal domains of hoPL were involved in the inactivation of the protein at the water–t...

Ngày tải lên: 16/03/2014, 06:20

... anti-apoptotic members of the bcl -2 family including bcl -2 and bag-1. For instance, the prosurvival activity of ERK1 /2 in PC 12 cells may proceed via CREB-stimulated expression of bcl -2 [40]. Furthermore, in HSV2-infected ... signaling ERK1,alsoknownasp44mitogenactivatedproteinkinase (MAP kinase), and ERK2 (p 42 MAP kinase) are closely related protein kinases of...

Ngày tải lên: 30/03/2014, 14:20

... mediator of lethal sepsis, triggering the production of proinflammatory cytokines and liver injury [13]. Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform ... drug-metabolizing dysfunction during sepsis FEBS Journal 27 8 (20 11) 23 07 23 17 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 23 17 Role of Kupffer...

Ngày tải lên: 14/02/2014, 18:20