Báo cáo khoa học: RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum pdf
Báo cáo khoa học: RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum pdf
... 2008 The Authors Journal compilation ª 2008 FEBS 2931 RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum Chieka ... positions of the introns are indicated by red lines, and the numbers above indicate the positions of the introns as described...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... Similarly, the 33 ordered residues in the T structure (that are disordered in the N form) are not related to the Tris-binding site resi- dues in any way. Thus, the effect of Tris binding on the glutaminase ... aa; nine aa in total) were located near the interface of the physiological dimer. The C- terminal domain may contain structural features involved in prot...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site potx
... of 3.8 A ˚ .In PR V82A , the change in the position of the main chain atoms placed the Cb atom of Ala82 within reasonable van der Waals distance of indinavir (4.1 A ˚ ), resulting in a loss of ... oxygen of Gly27, the OD1 of Asp29¢ and the NE atom of Arg8. The N4 atom of indinavir interacted with the carbonyl oxygen of Gly27¢. The indinavir O1 and O...
Ngày tải lên: 23/03/2014, 12:20
Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
... demonstrating that the binding of Glc at the active site indeed induces a large-scale domain move- ment that closes the active site cleft and creates the stereochemical environment for binding of the ... involved in the binding of D-glucose in the super-open state (PDB identity: 1v4t). The structural images were generated using PYMOL, version 0.99. Activation of gl...
Ngày tải lên: 30/03/2014, 04:20
Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
... RNA-binding and enoyl-CoA-hydratase activity. In addition, it was shown that muta- tions in the AUH gene are linked to MGA1. Here we present kinetic data of the purified gene product of AUH using ... hydratase’). The RNA- binding activity of the human protein and also of the murine homologue was investigated further, its biologi- cal function, however, remained unclea...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites doc
... were determined (Table 1). The binding affinities of the inhibitor to both binding sites, yielding the IE or EI complex, were only slightly different. On the other hand, the binding affinity of the second ... Ile8 of the peptide interacting with the Tyr752 hydroxyl group of the enzyme. A hydrophobic interactionofthesidechainofMet1ofTat(1–9)withthe phenyl ring of the...
Ngày tải lên: 20/02/2014, 11:20
Báo cáo khoa học: Heterologous synthesis of cytochrome c¢ by Escherichia coli is not dependent on the System I cytochrome c biogenesis machinery ppt
... c 552 proteins, respectively. The band denoted by the asterisk on the right-hand side is the result of nonspecific staining of the extracts containing the PH c 552 protein. Biogenesis of cytochrome c¢ H. Inoue et ... results that the co-expression of the ccm genes in the pEC86 plasmid and the presence of the DsbD protein are not necessarily required for the...
Ngày tải lên: 06/03/2014, 00:20
Báo cáo khoa học: Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells pot
... by the main fuel sources in muscle and by insulin through directly altering the expression of the human PDK2 and PDK4 isoforms. In addition to our findings, insulin has been shown to decrease the ... expression of these isoforms. The regulatory in uence of glucose, fatty acids and insulin on PDK2 and PDK4 mRNA expression We examined the effects of the two predominant...
Ngày tải lên: 07/03/2014, 17:20
Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging pdf
... 5.1-fold, respectively. Increased protein level of TFAM induced by D-Gal To further understand the expression of TFAM protein in the inner ear, western blot analysis was performed. The protein levels of TFAM in the ... in mutant mtDNA harboring the com- mon deletion. By applying the specific probe, we can even detect the presence of the common deletion in the...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: Intracellular degradation of somatostatin-14 following somatostatin-receptor 3-mediated endocytosis in rat insulinoma cells doc
... min. The recov- ery of surface binding sites was determined as described above. Interestingly, during the first 15 min of incuba- tion, surface binding recovered to 76%. However, incu- bation of ... subtypes in their inter- action with arrestins indicate the existence of internali- zation and trafficking pathways that are specific for the SSTR subtypes. Determining the fate...
Ngày tải lên: 16/03/2014, 06:20