Báo cáo khoa học: Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases docx

... (1993) Activation of the zymogen of hepatocyte growth factor activator by thrombin. J Biol Chem 268, 22927–22932. 11 Miyazawa K, Shimomura T & Kitamura N (1996) Acti- vation of hepatocyte growth ... Activation of HGFA by tissue kallikreins FEBS Journal 275 (2008) 1003–1017 ª 2008 The Authors Journal compilation ª 2008 FEBS 1017 Activation of hepatocyte...

Ngày tải lên: 23/03/2014, 07:20

... the activation of RhoA which occurs within 5 min of TGFb stimulation. This activation lasts for a short time (15 min to 3 h, depending on the cell type) and is followed by the activation of down- stream ... NET1, the inhibitory Smad7 protein and the RhoB gene. Activation of cofactors such as serum response factor, AP1, GATA and myosin enhancer factor 2 via p38 MAPK or oth...

Ngày tải lên: 07/03/2014, 01:20

... demonstrate that suppres- sion of p38 kinase activation by SB203580, as well as suppression of JNK1 activation by JNK inhibitor I and AS-jnk1, caused equal inhibition of c-Jun phos- phorylation. ... Sciences, Faculty of Science, University of Auckland, New Zealand 2 Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University...

Ngày tải lên: 07/03/2014, 12:20

... active form of tPA and Plg simultaneously and by bringing the two components together, it acts as a cofactor in the activation of Plg to plasmin. The ability of TN to accumulate by one or another ... in Fig. 3 as a plot of the reaction velocity v a vs. the concentration of Plg. The analysis reveals the kinetic parameters of the activation of Plg by tPA in the presence...

Ngày tải lên: 17/03/2014, 03:20

... (1992) Human epidermal growth factor: high resolution solution struc- ture and comparison with human transforming g rowth factor alpha. J. Mol. Biol. 227, 271–282. Ó FEBS 2004 Folding of EGF ... Role of the 6–20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Sci. 7, 1738–1749. 17. Valcarce, C., Bjork, I. & Stenflo, J. (1999) The epiderma...

Ngày tải lên: 23/03/2014, 13:20

... evolutionarily guaranteed by the presence of a variety of ligands, or by dimerization and trans -activation with other family member receptors of ErbB [2,3]. Additionally, the potency and dynamics of EGFR signaling ... 5239 Introduction Epidermal growth factor receptor (EGFR) is a mem- brane tyrosine kinase that is involved in the regulation of a wide variety of biologica...

Ngày tải lên: 30/03/2014, 01:20

... hydrocarbo ns. To ev aluate the effect of membrane properties a nd distinct phospholipids o n t he activity of human CYP1A1 purified insect cell-expressed human CYP1A1 and of human NADPH-P450 reductase were reconstituted ... increased by the introduction of anionic lipids, but not by that of nonbilayer lipids. Thus, c harged lipids affect the stereose- lectivity of the epox...

Ngày tải lên: 08/03/2014, 10:20

... the C-terminus of the p180 subunit of human DNA poly- merase a-primase [26]. The genome of JCV is 69% homologous to that of SV40 and expresses an analogous set of proteins [31]. The core origins of replication ... governed by a host factor such as nuclear factor I (NF-I) required to facilitate initiation of replication in vivo but not in vitro, perhaps by alleviating n...

Ngày tải lên: 17/03/2014, 03:20

... the loss of phosphatidylinositol 4,5-bisphosphate and a resul- tant reduction in Ca 2+ sensitivity of TRPM4b [9,10]. Launay et al. proposed that depolarization of cells after activation of TRPM4b by ... indicated by arrow; solid lines) or untreated (dashed lines). (B) Quantitative analysis of the amplitude of Ca 2+ released by ionomycin (left) and the amplitude of Ca 2+...

Ngày tải lên: 23/03/2014, 09:21

... of high affinity binding site location. The AChBP, which is secreted by the glial cells of the snail, Lymnaea stagnalis , is a truncated homologue of the extracellular amino terminal domains of ... Loop D of the LGIC family. (A) Amino acid sequence align- ments of residues lying in loop D of the a1, c and d subunits from Torpedo californica (T. Ca) nAChR, human (H) a1 nAChR s...

Ngày tải lên: 19/02/2014, 07:20