Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
... 6116–6127 ª 2007 The Authors Journal compilation ª 2007 FEBS 6127 Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 Monica Averna, ... capacity of calpain. The physiological rele- vance of this novel property of HSP90 is also dis- cussed. Results Degradation of NOS isozymes i...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Space, time and nitric oxide – neuronal nitric oxide synthase generates signal pulses pptx
... described the rise of the absorbance, which slightly falls off after 500 ms. This is a reasonable mea- sure of the time frame formation of the ferrous oxygen complex, which is limited by the rate of ... °C at the present level of detail, demon- strating pulsed catalysis under these conditions. This confirms the central premise of the model: the progres- sive...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging pdf
... the com- mon deletion. By applying the specific probe, we can even detect the presence of the common deletion in the inner ear in the control group. The proportions of the common deletion in the ... of TFAM induced by D-Gal To further understand the expression of TFAM protein in the inner ear, western blot analysis was performed. The protein levels of...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: Metal exchange in metallothioneins – a novel structurally significant Cd5 species in the alpha domain of human metallothionein 1a ppt
... model of Cd 4 a-rhMT 1a in two orientations rotated by 90°, emphasizing the crevice site on the domain. One of the proposed ligands of the fifth Cd 2+ ion, Cys34, is highlighted by the arrow and the ... compared with the Zn 3 b domain of MT 3, indicating non-isostructur- al replacement of Cd 2+ for Zn 2+ in this particular MT isoform. This charge state distributio...
Ngày tải lên: 16/03/2014, 06:20
Tài liệu Báo cáo khoa học: Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins pdf
... thus their expression in H. perforatum tissues could not be distin- guished from each other, the general name HpPKS2 is used in this study. Phylogenetic analysis The overall similarity of the ... Expression of HpPKS2 was found to correlate with the concentration of hyp- ericins in H. perforatum tissues and HpPKS2 is thus a candidate gene for the biosynthesis of hyper...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 pptx
... subunits of PDH1, PDH2 and T. profundus dye-l-proDH. The amino-acid sequence of the a1 subunit of PDH1 showed 31% and 32% identi- ties with the a2 subunit of PDH2 and the a subunit of the T. profundus ... stream from the 5¢-terminus of the predic- ted ORF, is the proper initial codon for a2. The N-ter- minal amino-acid sequences of the b2 and c2 subunits co...
Ngày tải lên: 20/02/2014, 01:20
Báo cáo khóa học: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy pdf
... to Btf is specifically and selectively disrupted by the disease-associ- ated S54F missense mutation in emerin. The implications of these findings for possible EDMD disease mechanisms are discussed. Materials ... unpublished results). This group of interactors support gene expression models for emerin function and, potentially, the disease mechanism of EDMD and further suggest...
Ngày tải lên: 23/03/2014, 12:20
Báo cáo khoa học: Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding docx
... [28], indicating that the potential of the flavin couples is the sole determinant of the redox equilibrium within the enzyme under these conditions, and hence of the nature of the equilibrium perturbation ... site is contained within the FAD-binding domain of the protein (Fig. 2). The electron density for the NMN portion of the coenzyme is poorly define...
Ngày tải lên: 23/03/2014, 17:22
Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... proteolytic degradation by calpain. The efficiency of this effect is directly related to the level of intracellular HSP90 expression, generating a high HSP90 to NOS ratio, which favours both the ... complexes of NOS with HSP90 are crucial in determining the in vivo resistance of NOS and HSP90 to calpain degra- dation. Results Levels of HSP90 and NOS is...
Ngày tải lên: 30/03/2014, 04:20
Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... of insect Spa ¨ tzle cystine-knot domains. Fig. S3. Analysis of the relative abundance of two Spa ¨ tzle isoforms in M. sexta. This supplementary material can be found in the online version of ... peptide is underlined. The proteolytic activation site is indicated with ’i’. The N-terminal sequence, determined by Edman degradation, of the activated form of Spa...
Ngày tải lên: 06/03/2014, 09:22