... containing x-conotoxins, j-conotoxins,d-conotoxins, and lO-conotoxins; the M superfamily,containing l-conotoxins, w-conotoxins, and jM-cono-toxins; the S superfamily, containing r-conotoxins and ... 1.9 s (n ¼ 5). Insets: superimposed traces of the nicotine responses obtained in a typicalTE671 cell and in an a3b4-expressing cell during control and toxin perfusion. Left inset: the traces ... sequence determination and cloning of the cDNAencoding two novel peptides, SrIA and SrIB, found in the venom of Conus spurius. The pattern and the spa-cing of their cysteines indicate that they...