Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf

... clustered in the vicinity of the Inr might serve in transcription initiation (Fig. 1). Analysis of the 1.5-kb 5¢ flanking region, attempting to get further insight into the possible regulation of PP17 ... doi:10.1046/j.1432-1033.2003.03475.x role in intracellular lipid metabolism rather than in secretory protein sorting, taking into account that there is a high-level am...

Ngày tải lên: 23/03/2014, 21:20

... 609, included in D.M. 116 ⁄ 1992 of the Italian Ministry of Health. Focal cerebral ischemia Brain ischemia was induced by MCAo in male Wistar rats (280–320 g) by intraluminal filament, using the ... known to protect the brain against focal ischemia [35]. In order to investigate the role of the endocannabinoid system in the neuroprotection affo...

Ngày tải lên: 23/03/2014, 07:20

... higher rate of fibrillation, is opposite to the results obtained when a-synuclein was incubated in the absence of MPTP. When a-synuclein was incubated alone in the presence of dopamine, it led to inhibition ... solid line), in the presence of 100 l M neurotoxin ( • , dotted line), in the presence of 200 l M neurotoxin ( , dotted line) and in the presence of...

Ngày tải lên: 14/02/2014, 19:20

... The dele- tion of either ERG4 or NCP1 in the cla4D background is lethal, indicating that CLA4 and these genes, encod- ing proteins involved in sterol synthesis, may function in the same pathway(s) ... version of the enzyme Ura3 with an arginine at the extreme N-terminus, is targeted for degradation by the enzymes of the N-end rule. A pro- tein–protein interac...

Ngày tải lên: 18/02/2014, 13:20

... alanine mutation of this enzyme reduced the flavin binding energy by 0.5 kcalÆmol )1 [50]. In pea FNR, the sulfhy- dryl group of C266 is 6.17 A ˚ from the closest point of the isoalloxazine ring, ... of this residue in this enzyme is more permissible [59]. Another interesting outcome of our study is the fact that, in all cases, the mutations introduced dimin...

Ngày tải lên: 18/02/2014, 17:20

... binding of cadmium than zinc in metallothioneins and the preference of zinc in the more flexible b-domain. In addition to the already described differences in flexibility of the b-domain in MT isoforms ... to the different metal affinities for zinc and cadmium in the two separate domains [13], the b-domain has been implicated in zinc homeostasis and the tight...

Ngày tải lên: 07/03/2014, 15:20

... Nevertheless, information on the kinase-mediated phosphorylation of KAT1 and the target sites involved in the regulation of channel activity is scarce. In this study, we investi- gated the effect ... in plants, similar signaling pathways exist which connect the application of phorbol esters to the activation of certain kinases analogous to PKC. This is in lin...

Ngày tải lên: 22/03/2014, 21:21

... reversed by inhibition of the active export of drugs either by binding of inhibitors on sites located on the efflux pumps or by indirect inhibition of Pgp either through modulation of its lipid environ- ment ... to the kinetics of daunorubicin uptake into the resistant cells, the uptake rate was measured as the amount of drug taken up within 15 min after addit...

Ngày tải lên: 30/03/2014, 04:20

... states shows that binding of the substrate (nicotinic acid) is accompanied by the induced fit of helix F and helix E [10]. Rearrangement of helix F during the binding event results in a change in the torsional ... and increase the flexibility of the enzyme active site. The increased flexibility in the substrate-binding site leads to the increase in K m , i.e...

Ngày tải lên: 30/03/2014, 13:20

... the rates of respiration of mouse liver mitochondria. ACI, accep- tor control index, the rate of respiration in the presence of AsO 4 divided by the rate of respiration before the addition of ... mediated by a relief of inhibition by cyclophilin D was evident in the form of slightly increased respiration rates during arsenolysis. However, the modulatio...

Ngày tải lên: 14/02/2014, 19:20