Báo cáo khoa học: A decade of Cdc14 – a personal perspective Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria pdf

... regulation of aerobic metabolism and the induction of cell death, and new insight into the regulatory mechanisms operating in vivo.AbbreviationsAGC, aspartate ⁄ glutamate metabolite carrier; ... which the energization state (and thus the capacity to accu-mulate Ca2+) was shown to in uence the spatio-tem-poral pattern of the typical propagating Ca2+wavesinduced by IP3[45]. In mammals, ... similar to that proposed for the modu-lation of capacitative Ca2+ in ux, has been proposedby Nicholls and coworkers for the modulation of Ca2+activation-inhibition of glutamate and voltageoperated...

... reduction in sumoylation andincrease in transcriptional activation. Enhancing sumoy-lation by contransfection of PIASy had a negative effect on both Myb-induced and basal level reporter activation.Furthermore, ... subnuclear fractionation, whichindicates that sumoylation might be involved in modulating the protein–protein interactions of c-Myb.Materials and methodsPlasmids The yeast bait plasmid pDBT-hcM ... for the activity of the factor.Even a conservative mutation (KfiR) keeping the chargeunchanged, causes a large enhancement of the activity of c-Mybbothintransfectionassaysandwhenactivationofanendogenous...

... should have been. At the time, Bk was per-ceived as a mediator of pain and in ammation respon-sible for paralytic vasodilatation in the course of acutepancreatitis. The reasoning was as follows: ... PGI2-dependent mechanism [ 79] . In cultured bovine aorticendothelial cells lipophylic statins, i.e. atorvastatin,simvastatin and lovastatin (but not a hydrophilicpravastatin) at a concentration of 30 lm ... cardiovascular disorders, but they do support the idea of administrating of low doses of ASA along withACE-I (Fig. 3).Statins In our in vivo model statins (e.g. atorvastatin andsimvastatin) produce...

... 460, 90 9 9 13. 89 Hong H, Takahashi K, Ichisaka T, Aoi T, KanagawaO, Nakagawa M, Okita K & Yamanaka S (20 09) Suppression of induced pluripotent stem cell generationby the p53–p21 pathway. Nature ... Following trans-plantation and discontinuation of anti-retroviral ther-apy, no HIV-1 virus was detected in the patient over a 20-month period [22,23]. A combination of gene andcell therapy has also ... showed that the p53 pathwayacts not only as a tumor suppressor, but also sup-presses iPSC generation as determined using smallinterfering RNA and p53 mutation [ 89] . These findingsindicate the need...

... factor-depen-dent regulation of rDNA transcription [11].Acetylation is another post-translational modifica-tion that regulates the activity of UBF and SL1. Acet-ylation of TAFI68 by the the ... molecular path-ways that transmit information on the growth state of a cell population to the Pol I transcription apparatusrepresents a challenging and rewarding subject of research. The Pol I transcription ... RNAUBFTIF-IAT0Fig. 2. Cartoon depicting the structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation. The sites of transcription initiation...

... related yeast Kluveromyces lactis contain a uniquetranscription activation domain N-terminal to the DBD [4,5]. The HSF is a pre-existing transcriptionactivator that binds to an array of a 5-bp ... subcellular localization.Indeed, Kuge et al. [14] demonstrated that Yap1 nuc-lear retention is mediated by the cysteine-rich domain(CRD) located at the C-terminus of the protein whichcontains ... between Yap2 and Yap1 in the C-terminal CRD (residues 57 0–6 50 in Yap1 and 33 0–4 09 in Yap2) was used to further provide an insight into the function Yap2. Domain swapping of the Yap1 c-CRDby that of...

... importin -a nuclear import pathway, provided that CLIC4 can undergo a conforma-tional rearrangement that exposes the NLS in an extended conformation.DatabaseStructural data are available in the ... S-nitrosylation of CLIC4 has been found to induce a conformationalchange which destabilizes the native conformation.Such a destabilization may facilitate the interactionbetween the otherwise helical ... 7 2–4 96 ). The major binding site spanningARM repeats 2–4 has a similar conformation to the equivalent region in apo importin -a (7 0–5 29) , with anrmsd of 0.16 A ˚(46 C a atoms) across the inner...