... Laboratory of Insect Geneticsand Bioscience, Department of Agriculturaland Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo113-8657, ... Agricultural and Life Sciences, University of Tokyo, Japan5 Department of Biotechnology, Graduate School of Agricultural and Life Sciences, University of Tokyo, JapanIntroductionIsovaleryl-CoA ... structure.Consequently, the side-chain atoms of Val376 overlapwith those of Ile369, Leu372 and Thr383 with inter-atomic distances of < 3 A˚in the mutant structure(Fig. 7B). To avoid these overlaps,...