Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx

... DNA-binding domain (DBD) at the amino-terminus and the oligomerization domain in the central region of the protein [1,4]. The HSF DBD belongs to the ‘winged’ helix-turn-helix family of DNA-binding ... interactions. In HSF DBD– HSE co-crystals, the protein–protein interface consists of the helix 2 amino-terminus, the turn and the wing [15]. Unlike other winged helix-turn-helix protei...

Ngày tải lên: 18/02/2014, 04:20

... pairs of primers, which amplify overlapping 5¢- and 3¢-parts of ZF5 cDNA, were designed using Primer software developed by V. Prutkovsky and O. Sokur of the Institute of In uenza, Ministry of Health of ... Kuteikin KB (1994) Identification of a GC element in the promotor of the murine L32 ribosomal protein L32 gene and the 3¢-ter- minal region of the human apolipoprotein A...

Ngày tải lên: 07/03/2014, 05:20

... comple- mentarity of binding surfaces determine the binding orien- tation of the peptide in complex with CaM. The second interesting feature is the conformation of the CaMKK binding domain peptide in complex ... structure of the CaM/C24W complex [67]. The binding of the C20W peptide of the Ca 2+ -pump CaM-binding domain to only the C-terminal lobe of CaM demonstrates that...

Ngày tải lên: 17/03/2014, 09:20

... in nonselective protein degradation inside lysosomes, and is involved in the processing of other proteins and hor- mones such as trypsinogen and thyroglobulin [1–3]. Secreted cathepsin B is often ... mutations in this region, including mutations to prolines. On the basis of these results, a model for autocata- lytic activation of cysteine cathepsins is proposed, involving pr...

Ngày tải lên: 07/03/2014, 03:20

... self- reproduction, gaining a maximal biomass production at a given total flux is obviously equivalent to maintaining a given rate of biomass production at a minimum of the total flux. Insofar, the principle of maximal ... production is a special case of the more general principle of flux minimization. It has to be noted, furthermore, that mini- mization of fluxes in a metabolic...

Ngày tải lên: 07/03/2014, 15:20

... basic f-amino group of the coordinating K100, with the H-bonded water molecule found in the X-ray structure increasing the electron donating power of the coordinating amino group which in turn ... changes being minimal the trapping of two main-chain confor- mations and increased B-factors at 295 K suggests that the presence of the coordinating Lys in some way can in uence the d...

Ngày tải lên: 07/03/2014, 17:20

... (PDP). To date, four isoforms of PDK (PDK1–4) and two isoforms of PDP (PDP1–2) have been identified in humans [3–5]. These isoforms display unique tissue dis- tribution [3–5] and varied kinetic and regulatory ... suggesting that the MAPK signalling cascade is not involved in transducing the insulin-to-PDK transcriptional signal. The ability of U0126 to inhibit insulin-stimulate...

Ngày tải lên: 07/03/2014, 17:20

... 4B). We also confirmed inhibition of protein synthesis by monitoring expression of c-Fos protein, which is a Fig. 2. Activation of ERK1 ⁄ 2 pathway is involved in miR-221 ⁄ 222 induction. (A, B) PC12 ... sustained activation of ERK1 ⁄ 2by NGF, but not the transient activation of ERK, could effectively induce miR221 and 222 in PC12 cells. Finally we identified the BH3-onl...

Ngày tải lên: 16/03/2014, 01:20

... photosynthesis, metabolism of fatty acids, some amino acids, choline and betaine, and synthesis of vitamin B 6 , vitamin B 12 , folate, and protoporphyrin. FAD is also the coenzyme of glutathione ... oxidase-dependent folding of secretory proteins also depend on FAD [3–5]. In plants, FAD is involved in ascorbate (ASC) bio- synthesis and recycling, thus playing a crucial role...

Ngày tải lên: 16/03/2014, 04:20

... chemokine receptors, including CCR-2 and CCR-3 [12,13]. The role of MCP-4 ⁄ CCL13 in disease is less well defined, but recent studies suggest that it is involved in inflammatory cell recruit- ment in ... involved in the joint degrada- tion process in RA. Thus, MCP-4 ⁄ CCL13 might have roles not only in the proliferation of synovial cells but also in the invasion of...

Ngày tải lên: 16/03/2014, 05:20