Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt

... occupancy of MLL1, H3K4 trimethylation and RNAP II with Hox gene expression indicates the critical roles of MLL1 and H3K4 trimethylation in dif-ferential Hox gene expression during the cell cycle. ... homeobox-containing (Hox) genes (HoxA5, HoxA7 and HoxA10) are differentially expressed during the cell cycle, and the recruitment of MLL1 and H3K4 trimethylation levels are modulated in the promoter of these Hox ... at the beginning of the S phase(0 h), and these marks were attenuated for the rest of the cell cycle (10 and 20 h), correlating with the expression of the gene (Fig. 6C,D). The correlation of promoter...

Báo cáo khoa học: Functional association of the AAA complex and the peroxisomal importomer potx

... 5B and 6). These dataemphasize the speciﬁcity of the AAA–peroxin–Pex15p association and are in agreement with the idea of shut-tling of the AAA peroxins between cytosol and perox-isome with ... that the association of Pex15p with the com-ponents of the import machinery does not depend on the AAA peroxins. Moreover, these data indicate thatat least one of the contact sites of the AAA ... contaminate the eluates (Fig. 3A and data not shown), thereby con-ﬁrming the speciﬁty of the isolation. Taken together,these data indicate a close association of the mem-brane-bound AAA complex and the...

Báo cáo khoa học: Functional association of human Ki-1⁄57 with pre-mRNA splicing events docx

... colocalized with the Cajal body protein marker p80-coilin in the nucleus of HEK293 cells treated with Adox (Fig. 7Ai–iii). Thisﬁnding may, in addition, strengthen the hypothesis of the involvement of ... NationalInstitute of Mental Health, Bethesda, MD, USA). The intensities of all isoforms were summed, set as 100%, and used to normalize the intensity of each band.Microscopy analysesFor the subcellular ... (GST-fusion) and incubated with supernatants of cell lysates as indicated. Arrows indicate the detected proteins. Arrowheads point to the position of the control protein GST. The additional bands observed...

Báo cáo khoa học: Dynamic reorganization of the motor domain of myosin subfragment 1 in different nucleotide states docx

... the spheres with a radius of the length of the ﬂuorophores (< 103A˚3), indicating that the motion of the labels reﬂects the motion of the protein segment towhich they are attached. The ... open and closed conformations to provide the structural basis of the interaction of myosin with actin. The ﬂexibility of the 50 kDa upper domain was high in the open conformation and further ... changes within the motor domain of myosin, which lead to the sliding of the thick and thinﬁlaments relative to each other. Some of the intermediatestates of ATP hydrolysis are short-lived and thus...

Báo cáo khoa học: "Dynamic compilation of weighted context-free grammars" pot

... regular expression a(a). A dynamic substitution consists of the application of the substitution a to ~, during the process of recognition of a word sequence. Thus, after substitution, the language ... supports dynamic grammar changes without recompilation. Fur- thermore, the algorithm can be executed on de- mand: states and transitions of the automa- ton are expanded only as needed for the ... about the correct transcription of a spoken utterance, they instead generate a range of al- ternative hypotheses with associated probabil- ities. An essential function of the grammar is then...

Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx

... only (without the addition of ﬁbroblast homogenate) is applied to the HPLC-system the same picture appears. Thus, it seems, that the fronting, the shoulder and the tailing is due to acetyl-CoA and ... deﬁciencies of each of the six dif-ferent steps within the leucine degradation pathway(Fig. 1) cause their own characteristic disease [1]. The enzymes of this pathway are primarily located in the mitochondria. ... substrate [15]. The gene encodingthis bifunctional protein was named AUH (‘AU bind-ing homolog of enoyl-CoA hydratase’). The RNA-binding activity of the human protein and also of the murine homologue...

Tài liệu Báo cáo khóa học: New activities of a catalytic antibody with a peroxidase activity ppt

... hydroxylamines, the rate of complex formation is lower in the presence of the antibody, with a decrease in the rate constant of  7% beingobserved with hydroxylamine 1 andof>40%withthemore bulky ... a hydrophobicpocket with no change of the Fe(II) spin state and noreplacement of any of the two axial ligands of the iron,His18 or RNO, by an amino acid side-chain of the antibody protein.Binding ... prevent the binding of a ligand, such as nitrosoalcane, to the iron of MP8, it brings a partial steric hindrance on the distal face of MP8 and thus controls access of the nitrosoalcane ligandto the...

Tài liệu Báo cáo khoa học: "Semantic Classification of Noun Phrases Using Web Counts and Learning Algorithms" ppt

... relations. Over the set of 5 semantic rela-tions defined by Nastase and Szpakowicz (2003), they achieve an accuracy of 45.7% for the task of assigning one of 5 semantic relations to each of the 600 ... dataset of 597 examples. The data is labeled with two different sets of semantic relations: one set of 30 relations with fairly specific meanings, and another set of 5 rela-tions with more ... to sum the number of hits for the term on its own, the term followed by 'a' and the term followed by &apos ;the& apos;. In-stead of conducting separate queries for each of these forms,...

Báo cáo khoa học: Functional dissection of Escherichia coli phosphotransacetylase structural domains and analysis of key compounds involved in activity regulation potx

... protein.On the other hand, in order to evaluate the contri-bution of the N-terminal end to the formation of the ﬁnal oligomeric state of Pta, the native conformationalstate of the truncated ... but not identical, to the spectrum of the entire protein (Fig. 4). The differences among the spectra may be due to the lack of different regions of the N-terminal end in the truncated Ptas.Pta-F1Pta-F2Pta-F3100200 ... foracetyl phosphate, with a relatively high kcatvalue(227.6 s)1; Table 1).On the other hand, despite the absence of the N-ter-minal end in the three truncated Ptas, the afﬁnity for the two substrates,...

Báo cáo khoa học: "Semantic Types of Some Generic Relation Arguments: Detection and Evaluation" pptx

... for the other.Generalization per argument is, on the one hand,useful because none of the arguments share a seman-tic category with the corresponding arguments of allnegative examples. On the ... the re-quirement of the syntactic closeness of the argu-ments. Further, their deﬁnitions have various restric-tions on the nature of the arguments. Short descrip-tion of the relation types ... Arguments:Detection and EvaluationSophia KatrenkoInstitute of InformaticsUniversity of Amsterdam the Netherlandskatrenko@science.uva.nlPieter AdriaansInstitute of InformaticsUniversity of Amsterdamthe...

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