Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt

... occupancy of MLL1, H3K4 trimethylation and RNAP II with Hox gene expression indicates the critical roles of MLL1 and H3K4 trimethylation in dif- ferential Hox gene expression during the cell cycle. ... homeobox-containing (Hox) genes (HoxA5, HoxA7 and HoxA10) are differentially expressed during the cell cycle, and the recruitment of MLL1...

Ngày tải lên: 23/03/2014, 06:20

... 5B and 6). These data emphasize the specificity of the AAA–peroxin–Pex15p association and are in agreement with the idea of shut- tling of the AAA peroxins between cytosol and perox- isome with ... that the association of Pex15p with the com- ponents of the import machinery does not depend on the AAA peroxins. Moreover, these data indicate that at leas...

Ngày tải lên: 07/03/2014, 12:20

... colocalized with the Cajal body protein marker p80-coilin in the nucleus of HEK293 cells treated with Adox (Fig. 7Ai–iii). This finding may, in addition, strengthen the hypothesis of the involvement of ... National Institute of Mental Health, Bethesda, MD, USA). The intensities of all isoforms were summed, set as 100%, and used to normalize the intensity of each b...

Ngày tải lên: 16/03/2014, 02:20

... the spheres with a radius of the length of the fluorophores (< 10 3 A ˚ 3 ), indicating that the motion of the labels reflects the motion of the protein segment to which they are attached. The ... open and closed conformations to provide the structural basis of the interaction of myosin with actin. The flexibility of the 50 kDa upper domain was high...

Ngày tải lên: 23/03/2014, 15:21

... regular expression a(a). A dynamic substitution consists of the application of the substitution a to ~, during the process of recognition of a word sequence. Thus, after substitution, the language ... supports dynamic grammar changes without recompilation. Fur- thermore, the algorithm can be executed on de- mand: states and transitions of the automa- ton...

Ngày tải lên: 31/03/2014, 04:20

... only (without the addition of fibroblast homogenate) is applied to the HPLC-system the same picture appears. Thus, it seems, that the fronting, the shoulder and the tailing is due to acetyl-CoA and ... deficiencies of each of the six dif- ferent steps within the leucine degradation pathway (Fig. 1) cause their own characteristic disease [1]. The enzymes of this pat...

Ngày tải lên: 19/02/2014, 07:20

... hydroxylamines, the rate of complex formation is lower in the presence of the antibody, with a decrease in the rate constant of  7% being observed with hydroxylamine 1 andof>40%withthe more bulky ... a hydrophobic pocket with no change of the Fe(II) spin state and no replacement of any of the two axial ligands of the iron, His18 or RNO, by an amino acid...

Ngày tải lên: 19/02/2014, 12:20

... relations. Over the set of 5 semantic rela- tions defined by Nastase and Szpakowicz (2003), they achieve an accuracy of 45.7% for the task of assigning one of 5 semantic relations to each of the 600 ... dataset of 597 examples. The data is labeled with two different sets of semantic relations: one set of 30 relations with fairly specific meanings, and an...

Ngày tải lên: 20/02/2014, 12:20

... protein. On the other hand, in order to evaluate the contri- bution of the N-terminal end to the formation of the final oligomeric state of Pta, the native conformational state of the truncated ... but not identical, to the spectrum of the entire protein (Fig. 4). The differences among the spectra may be due to the lack of different regions of the N-term...

Ngày tải lên: 06/03/2014, 11:20

... for the other. Generalization per argument is, on the one hand, useful because none of the arguments share a seman- tic category with the corresponding arguments of all negative examples. On the ... the re- quirement of the syntactic closeness of the argu- ments. Further, their definitions have various restric- tions on the nature of the arguments. Short descrip...

Ngày tải lên: 08/03/2014, 01:20