Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx

... compilation ª 2008 FEBS Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice Anna Lord 1 , Hillevi Englund 1 , Linda So ¨ derberg 2 , Stina Tucker 2 , ... pro- nounced with a probe trial at 24 h. Interestingly, high levels of protofibrils, but not total Ab, were associated with inferior spatial learning, at...

Ngày tải lên: 23/03/2014, 06:20

... : 2000 in blocking solution for 30 min. Cells were rinsed in NaCl ⁄ P i several times and incubated in blocking serum containing anti-mouse IgG (Vectastain) for a fur- ther 30 min. Staining was ... 2). These data indicate that both peptides accumulate in inclusion bodies, and that Ab(L1–40) is the dominant protein in the inclusion bodies. In contrast, the major protein in the Ab...

Ngày tải lên: 18/02/2014, 13:20

... histidine, isoleucine, leucine, phenyl- alanine, proline, serine, threonine, tyrosine, and valine for [U- 13 C]glucose experiments and aspartate, isoleucine, leu- cine, phenylalanine, serine, ... E4P (1)4) P5P U P5P (1)5) 1 P5P (1)5) Amino acid Serine U Serine (1)3) Serine (2)3) Serine (1)2) 1 Serine (1)3) Serine (2)3) Serine (1)2) Glycine U Glycine (1)2) 1 Glycine (1)2) Substrate Glucose U G...

Ngày tải lên: 20/02/2014, 23:20

... use of online learning as one possible way to successfully incorporate user feedback in IMT systems (Ortiz- Mart ´ ınez et al., 2010). In the online learning setting, models are trained sample ... length model, inverse and direct phrase- based models, source and target phrase length mod- els and a reordering model. 4 Online Learning In the online learning paradigm, learning pr...

Ngày tải lên: 07/03/2014, 22:20

... extinction coefficients (Table 1). Kinetic constants were determined using the initial rate method. Initial rates (v) were determined from linear regression fitting to at least 10 experimental points ... forms of hypoxanthine (Hx) and inosine (Ino), guanine (Gua) and guanosine (Guo), and xanthine (Xan) and xanthosine (Xao). Note that the monoanions of the latter are still 6-oxopurines, like the...

Ngày tải lên: 31/03/2014, 09:20

... amyloid b-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nat Med ... specifically increased in astrocytes in the cortical area of AD patients where neurodegeneration was evident [14], indicating that lipid metabolism, including that of LPC, may be change...

Ngày tải lên: 06/03/2014, 01:20

... 3,5,3¢,5¢-tetraiodo-l-thyr- onine (thyroxine) and retinol by binding to the retinol- binding protein when it is loaded with retinol [1]. TTR is mainly expressed in the adult liver, the choroid plexus of the brain, and ... pro- lines and alanines [46,47], and increased hydrogen bonding of the polypeptide chain [48–50]. In addition, improved intersubunit contacts within oligomeric pro- te...

Ngày tải lên: 16/03/2014, 01:20

... to (head- lines of) a news corpus. A headline is retrieved if it contains at least one of the overused words and is dated within the peaking interval or the day be- fore the beginning of the ... linked to ongoing events in the blogger’s life. Second, the blog contents tend to be unmoderated and subjec- tive, more so than mainstream media—expressing opinions, thoughts, and feeling. Finally,...

Ngày tải lên: 24/03/2014, 03:20

... that determine the interindividual variation in b 2 GPI plasma levels. Here we report the existence of a mutation at position )1(CfiA) in the 5¢ flanking region of b 2 GPI, which is in linkage disequilibrium ... of interindividual variation in b 2 GPI plasma levels, ranging from immunologically undetectable to as high as 35 mgÆdL )1 , with a mean value of 20 mgÆdL )1 in whitepeopl...

Ngày tải lên: 31/03/2014, 07:20

... obtain CXRs after insertion of endotra- cheal tubes, intravenous lines and chest drains, but not after insertion of nasogastric tubes. In addition, CXRs were obtained in the case of worsening ... purposes) attending physician; and 'old expected finding' was any old finding predicted by the attending physician; a 'new unex- pected finding' was any new finding not predic...

Ngày tải lên: 25/10/2012, 10:39