Báo cáo khoa học: Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes Viktor Viglasky potx

... Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes Viktor Viglasky Department of Biochemistry, ... carcinogenesis. The telomeric regions of DNA and nucle- ase hypersensitive elements of human c-myc and PDGF-A promoters repre- sen...

Ngày tải lên: 23/03/2014, 06:20

... 11cRAL to cone photoreceptors in cone-dominant species. Identification of an alterna- tive visual cycle will contribute to the understanding of the functional differ- ences of rod and cone photoreceptors. Structured ... (ortho- logue of human RPE65) and retains all of the known key residues for the enzymatic activity of RPE65. Similar to the other RPE-specific RPE65, RPE...

Ngày tải lên: 14/02/2014, 14:20

... signalling and resistance to apoptosis through downregulation of tBid, providing further details on how EGF receptor and proteasome inhibitors can contribute to the induction of apoptosis and the ... changes that occur during apoptosis. The mitochondrial release of cytochrome c and second mitochondria-derived activator of caspase (Smac ⁄ DIABLO) allows for the formation o...

Ngày tải lên: 16/02/2014, 09:20

... transport of pro-transforming growth fac- tor (TGF)-a [37], CD8a or the frizzled receptor Fz4 [38], as well as in the Golgi retention of p24a, a mem- ber of the p24 family of cargo receptors [39]. In ... complex formation and activation of pro-MT1-MMP. (A) Lysates of bbHT1080 cells trans- fected with pCDNA3.1 Zeo+ vector control (lane 1), pCDNA3.1 Zeo+ and furin (lane 2), pCDN...

Ngày tải lên: 18/02/2014, 04:20

... result is the first demonstration of the assembly of catalytic subunits of an invertebrate AChE into asymmetric forms. The evolution of the T peptide and tetrameric forms of AChE However, one question ... the hydroly- Fig. 2. Amino acid sequences of T peptides found in vertebrates and deuterostome and protostome invertebrates. Top, alignment of T amino acid sequences: Ve...

Ngày tải lên: 18/02/2014, 17:20

... previously and shown in Fig. 1C, Tom20 and Tom22 migrate closely together on this gel system [30]. Tom70 and Tom71 also migrate closely together on the gel, and the relative intensity of Coomassie staining ... primary structure with many strands of alternating hydrophi- lic and hydrophobic residues and a high abundance of aromatic residues that tend to be placed at the sta...

Ngày tải lên: 19/02/2014, 07:20

... transcription factors such as nuclear factor-jB and nuclear factor of activated T cells. Neutralization of COX-2 is the goal of many anti-inflammatory drugs. As an activator of COX-2 induction, ESE-1 ... as well. Together with our previous reports of the role of ESE-1 as an inducer of nitric oxide syn- thase in endothelial cells and as a mediator of pro-inflammatory cytokine...

Ngày tải lên: 19/02/2014, 17:20

... kinetics of unfolding and autoproteolysis Unfolding of pWT and G8C ⁄ N60C at the standard calcium concentration of 5 mm was monitored by far- UV CD spectroscopy, showing conformational changes of the ... of unfolding and autoproteolysis of G8C ⁄ N60C and pWT. In contrast to previous studies on the kinetics of thermoinactivation [13,24], this approach allows quantificati...

Ngày tải lên: 19/02/2014, 17:20

... which aspects of PROMODES-H in comparison to PRO- MODES led to the above described differences in performance. For this reason we broke down the summary measures of precision and recall into their original ... cross-validation into training and test subsets with the ratio of 9:1 we randomly split the data into training, validation and test sets with the ratio of 8:1:1. We...

Ngày tải lên: 20/02/2014, 04:20

... such as blogs and forums, and use information retrieval tasks for measuring their ability to properly process dialectal Arabic content. The work of Irvine and Klementiev (2010) is sim- ilar to ours ... over 6,000 screens, with the top 25 annotators supplying about 80% of the labels, and the top 50 annotators supply- ing about 90% of the labels. We consider a sentence to...

Ngày tải lên: 20/02/2014, 04:20