Báo cáo khoa học: Energy barriers for HET-s prion forming domain amyloid formation potx

... The HET-s prion displays a globu- lar a-helical domain appended to a natively unfolded domain termed the prion- forming domain (PFD). This PFD is the C-terminal 218–289 fragment responsible for prion ... 2009) doi:10.1111/j.1742-4658.2009.07202.x The prion- forming domain comprising residues 218–289 of the fungal prion HET-s forms infectious amyloid fibrils at physi...

Ngày tải lên: 23/03/2014, 05:22

... us- ing two sources of information: (1) the Inter- net for gathering statistics for word-word co- occurrences and (2)WordNet for measuring the semantic density for a pair of words. We report ... average accuracy of 85.7% for nouns, 63.9% for verbs, 83.6% for adjectives and 86.5% for adverbs, slightly less than our re- sults. Moreover, for applications such as infor- m...

Ngày tải lên: 08/03/2014, 06:20

... precursors for amyloid formation. J Biol Chem 279, 14111–14119. 74 Plakoutsi G, Bemporad F, Calamai M, Taddei N, Dobson CM & Chiti F (2005) Evidence for a mecha- nism of amyloid formation ... b 2 m amyloid Fig. 4. Prion- like conversion during amyloid formation. (A) Summary showing the structures of wild-type b 2 m (PDB code 2XKS) and a model of I T . Above, keys for t...

Ngày tải lên: 28/03/2014, 22:20

... the patient has options for ‘survival’ that they did not have before, even though they are dependent on ‘life support’. There are now variables Commentary Medical treatment for the terminally ill: ... to accept the pie in the sky bye and bye long shot cure’. If the patient can just be maintained comfortably for long enough, then a cure may eventually become possible. 3. Surrogates disli...

Ngày tải lên: 25/10/2012, 10:45

... (http://riodb.ibase.aist.go.jp/rcmg/ggdb/) provides users with easy access to information on glyc- ogenes. In the GGDB, the information on each glyco- gene is stored in XML format: gene names (gene symbols), enzyme names, ... malignant transformation. Lectin microarray – a powerful technology for selection of lectins for cancer glyco-biomarkers The lectin microarray system is an emerging...

Ngày tải lên: 16/02/2014, 08:20

... simulation in water of the 50 lowest -energy struc- tures [55], the 10 lowest -energy structures were selected as representative of the Anp32a LRR domain structure and used for statistical analysis. In ... into the groove formed by the concave surface of the LRR domain. Stabilizing interactions could form between His230 of PP2A-C and Asp119 and Asn94 of Anp32a. A salt bridge could for...

Ngày tải lên: 18/02/2014, 17:20

... cleft formed by the two domains. A common functional conformational change has been reported in this protein family, which involves switching from an open form to a sugar-transporter bindable form, ... N -domain and c-CD are much fewer than those between the C -domain and c-CD (Fig. 3B), region N-II plays an important role to form the TvuCMBP–c-CD complex (Fig. 5A). The positions and the co...

Ngày tải lên: 19/02/2014, 00:20

... product P40 of MPN142, formerly called ORF6 gene. Combining mass spectrometry with a method for sulfonating specifically the free amino terminal group of proteins, the cleavage site for a typical signal ... SPase typical for Gram-positive bacteria or for Gram-negative bacteria (such as LepB) has been identified in M. pneumoniae, although a SPase I activity has been shown to be essential...

Ngày tải lên: 19/02/2014, 18:20

... S 1 , which contains all of the information that is in the input sentence. The part of the information that is implicit in the sentence (tense, voice, and so forth) is made explicit in S 1 . ... well take the form of a program written in a pseudo code, program- mable on a general-purpose computer. Earlier estimates 9 that the amount of storage neces- sary for syntactic information...

Ngày tải lên: 19/02/2014, 19:20

... is a transformation of the Penn Treebank (PTB) data into CCG deriva- tions, and it is the standard corpus for English CCG parsing. Other CCG corpora have been induced in a similar way for German ... James R. Curran e -lab, School of Information Technologies University of Sydney NSW, 2006, Australia {dominick.ng,james.r.curran}@sydney.edu.au Abstract Optimising for one grammatical repres...

Ngày tải lên: 19/02/2014, 19:20