Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc
Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc
... detectable binding. To determine whether the decrease in binding affinity in the other chimeras was the result of protein instability and misfolding orwas merely a byproduct of the localization of chimeras in ... our modeling of the C5aR places the TM1 residues (I38, V42, V46, L49,L53 and W60) on the lipid-facing portion of the TM.Furthermore, mapping of the essential residues in TM1 of the C5aR did ... suggestingthat the lipid-facing residues within a single TM segment are not essentialfor oligomerization. These studies highlight the importance of the lipid-facing residues in the complement factor...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge ... affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these morphemes in an attempt to determine in which ... HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon 9 meanings for subsequent time intervals of the process. Depending...
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Báo cáo khoa học: A novel mass spectrometric approach to the analysis of hormonal peptides in extracts of mouse pancreatic islets ppt
... performed in orderto get an overview of the many compounds of the pancreaticislet extract (Fig. 1a). The prominent signals in the spectrumoriginated from products of proinsulin. Two insulin variantsare ... is produced in the pancreatic a-cells and in the L-cells of the intestines. The post-translational process-ing of proglucagon is tissue-specific. In the pancreatica-cells, the main products ... 60–80% of the islets and as insulin makes up almost20% of the proteins in the b-cells, proinsulin-derivedpeptides can be expected to constitute quantitatively pre-dominant components of the extracts....
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Báo cáo khoa học: A novel splicing variant form suppresses the activity of full-length signal transducer and activator of transcription 5A pot
... splicing variant of STAT5A,STAT5A_DE18, from a cDNA library of the mousebrainstem. The variant protein was generated by aframeshift in the C-terminal region, resulting in dele-tion of the ... 793 amino acid protein composed of aa-helical coiled-coil domain, a DNA-binding domain, an SH2 domain, and a C-terminal transactivation domain. The deletion of exon 18 (52 bp) in the STAT5A_DE18 ... splicing, suggesting that these variants areinvolved in specific functions. The physiological role of STAT5A_DE18 may involve the regulation of STAT5function in the brainstem, considering that...
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Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx
... function.Expression of defensin-coding andcathelicidin-coding genes The final combination of peptides at a specific locationreflects the signaling of pattern ⁄ pathogen-associatedreceptors as well as that of other ... in the triggering of an immuneresponse and in the natural process of elimination of activated antigen-presenting cells and termination of the immune response [90].HealingInfection and injury ... an in ammatory disease of the small intestine and ⁄ or the colon. As mentionedalready, in the small intestine, the pathogenesis is asso-ciated with a reduced expression of the Wnt signalingpathway...
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Tài liệu Báo cáo khoa học: Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebrafish (Danio rerio) doc
... lumen[43,44]. Considering the importance of the intestinalbarrier in the process of oral prion infection, this find-ing might help clarify the entry and routing of PrPSc in the early steps of infection. ... dpf in enterocytes of the pos-terior part of the intestine (Fig. 5M,Q,R). This lastfinding should be of interest because in terms of func-tion, the fish intestine is highly regionalized both in ... both in the larva and in the adult [38]. The posterior segment of the fish intestine is the absorption site of intact pro-teins, which might thus escape intracellular degrada-tion [39]. In the mammalian...
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Tài liệu Báo cáo khoa học: An engineered disulfide bridge mimics the effect of calcium to protect neutral protease against local unfolding docx
... Ger-many). The amount of intact protein was calculated from the intensity of the protein band.Autoproteolysis in sample solutions containing <20lgÆmL)1protein was followed by determining the ... the introduction of the disulfide bridge (at5mm CaCl2and 25 ° C) is obtained. The in uence of calcium ions on the unfoldingkinetics The in uence of the calcium ion concentration onunfolding ... increase in the Gibbs free energy of activation of unfolding undernative conditions. Using the linear extrapolation model[27], the rate constant for the unfolding of G8C ⁄ N60C in the absence of...
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Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx
... help them during the designphase, being able to reuse workflows (or parts of them) and thus avoiding reinveinting the wheel.4 Using the tools to work with NLPAll the aforementioned tools were installed, ... crawl the webpages in the domains and gather pairs of web documents in the target languages that belong to the targetdomain. Second, we apply a sentence aligner.14It takes as input the pairs of ... continue processing the rest of the input data if the workflow is robust (i.e. makesuse of retry and parallelisation) and the error isconfined to a WS (i.e. it does not affect the rest of the...
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Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot
... lysine or arginineresidue. Hence, peptide fragments not featuring alysine or arginine residue in the C-terminal ends ortruncated in the N-termini by some amino acids rela-tive to the preceding ... Critchley DR (1996) Acidicphospholipids inhibit the intramolecular associationbetween the N- and C-terminal regions of vinculin,exposing actin-binding and protein kinase C phosphory-lation sites. ... acidic phospholipids inhibit intra-molecular association between the N- and C-terminalregions of vinculin, exposing actin-binding and proteinkinase C phosphorylation sites on serines 1033 and1045...
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Báo cáo khoa học: Interaction between catalytically inactive calpain and calpastatin Evidence for its occurrence in stimulated cells docx
... concentra-tions of the metal ion [45]. The addition of E64, a syn-thetic inhibitor of calpain, did not modify the intensity of the signal observed in the presence of Ca2+alone. The increase in the mAb-binding ... presence of Ca2+, the addition of equimolar amounts of calpasta-tin induces an increase of approximately one order of magnitude in the affinity of calpain for mAb 56.3,indicating that, in these ... stimulation with the Ca2+ionophore(Fig. 6B), the intensity of calpain staining increased 7–8-fold, indicating that the protease was now mainlypresent in the high-affinity form. In these conditions,...
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