Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc

... detectable binding. To determine whether the decrease in binding affinity in the other chimeras was the result of protein instability and misfolding or was merely a byproduct of the localization of chimeras in ... our modeling of the C5aR places the TM1 residues (I38, V42, V46, L49, L53 and W60) on the lipid-facing portion of the TM. Furthermore, mapping...

Ngày tải lên: 23/03/2014, 04:21

... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge ... affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these morph...

Ngày tải lên: 21/02/2014, 20:20

... performed in order to get an overview of the many compounds of the pancreatic islet extract (Fig. 1a). The prominent signals in the spectrum originated from products of proinsulin. Two insulin variants are ... is produced in the pancreatic a-cells and in the L-cells of the intestines. The post-translational process- ing of proglucagon is tissue-specific. In...

Ngày tải lên: 17/03/2014, 10:20

... splicing variant of STAT5A, STAT5A_DE18, from a cDNA library of the mouse brainstem. The variant protein was generated by a frameshift in the C-terminal region, resulting in dele- tion of the ... 793 amino acid protein composed of a a-helical coiled-coil domain, a DNA-binding domain, an SH2 domain, and a C-terminal transactivation domain. The deletion of exon 18 (52 bp...

Ngày tải lên: 23/03/2014, 04:20

... function. Expression of defensin-coding and cathelicidin-coding genes The final combination of peptides at a specific location reflects the signaling of pattern ⁄ pathogen-associated receptors as well as that of other ... in the triggering of an immune response and in the natural process of elimination of activated antigen-presenting cells and termination of the imm...

Ngày tải lên: 18/02/2014, 06:20

... lumen [43,44]. Considering the importance of the intestinal barrier in the process of oral prion infection, this find- ing might help clarify the entry and routing of PrP Sc in the early steps of infection. ... dpf in enterocytes of the pos- terior part of the intestine (Fig. 5M,Q,R). This last finding should be of interest because in terms of func- tion,...

Ngày tải lên: 19/02/2014, 16:20

... Ger- many). The amount of intact protein was calculated from the intensity of the protein band. Autoproteolysis in sample solutions containing <20 lgÆmL )1 protein was followed by determining the ... the introduction of the disulfide bridge (at 5mm CaCl 2 and 25 ° C) is obtained. The in uence of calcium ions on the unfolding kinetics The in uence of the cal...

Ngày tải lên: 19/02/2014, 17:20

... help them during the design phase, being able to reuse workflows (or parts of them) and thus avoiding reinveinting the wheel. 4 Using the tools to work with NLP All the aforementioned tools were installed, ... crawl the webpages in the domains and gather pairs of web documents in the target languages that belong to the target domain. Second, we apply a sentence aligner....

Ngày tải lên: 22/02/2014, 03:20

... lysine or arginine residue. Hence, peptide fragments not featuring a lysine or arginine residue in the C-terminal ends or truncated in the N-termini by some amino acids rela- tive to the preceding ... Critchley DR (1996) Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C pho...

Ngày tải lên: 07/03/2014, 06:20

... concentra- tions of the metal ion [45]. The addition of E64, a syn- thetic inhibitor of calpain, did not modify the intensity of the signal observed in the presence of Ca 2+ alone. The increase in the mAb-binding ... presence of Ca 2+ , the addition of equimolar amounts of calpasta- tin induces an increase of approximately one order of magnitude in t...

Ngày tải lên: 07/03/2014, 12:20