Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt

... MINIREVIEW LRRK2 in Parkinson’s disease: genetic and clinical studies from patients Udhaya Kumari 1,2 and E. K. Tan 1,2 1 Department of Neurology, Singapore General Hospital, Singapore, Singapore 2 ... WD40 domain. Because WD40 domain is involved in mediat- ing protein–protein interactions, the LRRK2 G2385R variant may impact on interactions with substrates and ⁄ o...

Ngày tải lên: 23/03/2014, 04:20

... and alpha-synuclein in Parkinson’s disease. Antioxid Redox Signal 11, 2167–2187. 4 Kumari U & Tan EK (2009) LRRK2 in Parkinson’s disease: genetic and clinical studies from patients. FEBS J ... in concert with a number of conserved domains, including a GTPase domain. Multidomain proteins that encode functional kinase domains often utilize intrinsic protein kinase...

Ngày tải lên: 23/03/2014, 04:20

... FEBS MINIREVIEW LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles Zhenyu Yue Department of Neurology and Neuroscience, Mount Sinai School of Medicine, ... York, NY, USA Introduction Clinical symptoms of patients carrying Parkinson’s dis- ease (PD)-associated mutations of leucine-rich repeat kinase 2 (LRRK2) are indistinguishable...

Ngày tải lên: 23/03/2014, 04:20

... microdomains in which specific proteins could be recruited and possibly, to interact. Because cardiolipin is relevant for mPTP regulation and this inner membrane phospholipid is diminished in thyroid insufficiency, ... blot. Protein loading was determined by using anti-ANT polyclonal IgG. (C) Cytochrome c content in mitochondria (M) and in supernatants (SS) recovered after rBAX in...

Ngày tải lên: 07/03/2014, 05:20

... subtilisin in the presence of 98% (w/w) of KCl was tentatively explained by either rigid salt structure protecting the enzyme in organic solvents or polar environment of salt helping in maintaining ... side chains of amino acid residues of enzymes is important in nonaqueous media as well. Hence pH tuning (placing the enzyme in water at optimum pH of the enzyme, and lyophilizing) r...

Ngày tải lên: 16/03/2014, 16:20

... binding partner, specifically the globular domain IV of the b1 chain of laminin [23]. In vitro binding studies similarly indicated binding of acetyl- cholinesterase to laminin-1 [24], which was inhibited by ... site inhibitors (fasciculin, propi- dium and gallamine) and an anti-acetylcholinester- ase mAb. Increasing the ionic strength, or decreasing the pH decreased this binding [23,24...

Ngày tải lên: 23/03/2014, 07:20

... grammar modulo the terminal vocabulary and the rules which insert terminals. Another way of stating this is that the lexicon of Indonesian is finite but of an indefinite size (what Gurevich ... Third, weak generative capacity is in any case not a very interesting property of a formal grammar, especially from a linguistic point of view, since linguistic models are judged by other ....

Ngày tải lên: 24/03/2014, 02:20

Ngày tải lên: 29/03/2014, 08:20

... of TAGs. Finally the decrease in phospholipids, increase in free FAs and TAGs were accompanied by an increase in the FS content of this transformed yeast, probab ly to compensate for the change in the ... 3 M NaCl and purification from agarose (Nucleospin Extract purification kit), t he two fragments were hybridized due to the overlapping regions from the direct primer and the...

Ngày tải lên: 30/03/2014, 15:20

... from the source to all the English words (including the empty one), edges from all the French words (including the empty one) to the sink, an edge from the sink to the source, and edges from ... outgoing flow of an English word and the ingoing one of a French word must equal 1. We also have connections entering the English words, from a source, and leaving the French o...

Ngày tải lên: 17/03/2014, 07:20