Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc

... MINIREVIEW LRRK2 in Parkinson’s disease: function in cells and neurodegeneration Philip J. Webber and Andrew B. West Department of Neurology, Center for Neurodegeneration and Experimental ... but in concert with a number of conserved domains, including a GTPase domain. Multidomain proteins that encode functional kinase domains often utilize intrinsic protein kinase a...

Ngày tải lên: 23/03/2014, 04:20

... mitochon- dria into the cytosol through inactivation with Bcl-xL and Bcl-2 [69]. Inactivated Bax and Bad bind 14-3-3, the phosphoserine ⁄ threonine binding proteins in the cytosol. 14-3-3 prevents Bax and ... and probably its close paralog cas- pase-10 [46]. Pro-caspases exist in living cells and casp- ases are indispensable for the proliferation of some cell lines. When decid...

Ngày tải lên: 14/02/2014, 22:20

... specific domain. 1 Introduction In the past few years, there has been an increasing interest in research on developing systems for effi- cient recording of and access to multimedia meet- ing data 1 . ... user input from all modalities (speech, typing and pointing) and provides mul- timodal responses in the form of graphical, textual and vocal feedback. The dialogue manager contain...

Ngày tải lên: 20/02/2014, 12:20

... subsequent investigations of multilogue interaction. Information States We assume information states of the kind developed in the KoS framework (e.g. (Gin- zburg, 1996, forthcoming), (Larsson, 2002)) and ... increasedincidence and increasing active participant size. We plan to carry out more detailed work, both corpus–based and experimental, in order to evaluate the status of MAG a...

Ngày tải lên: 08/03/2014, 04:22

... examined that had arginine in this position may, in fact, represent GMDs. We are currently working to test experimentally whether exchange of arginine and glutamine at this position can interconvert ... aeruginosa isolates, and is maintained on the cell surface in chronic infec- tions. A-band O polysaccharide is apparently immuno- logically invisible to the host in the initial sta...

Ngày tải lên: 16/03/2014, 01:20

... Shen JR, Inoue Y & Sherman LA (1994) Role of disulfide linkage and putative intermole- cular binding residues in the stability and binding of the extrinsic manganese-stabilizing protein to the photosystem ... Yocum CF (1994) Role of disulfide linkage and putative intermole- cular binding residues in the stability and binding of the extrinsic manganese-stabilizing protein to the...

Ngày tải lên: 30/03/2014, 16:20

... FEBS MINIREVIEW LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles Zhenyu Yue Department of Neurology and Neuroscience, Mount Sinai School of Medicine, ... illustration of domain structures and alignment for LRRK2 and LRRK2 structure-related proteins. ANK, N-terminal ankyrin repeat domain; DEP, Dishevelled, EGL-10, pleckstrin d...

Ngày tải lên: 23/03/2014, 04:20

... WD40 domain. Because WD40 domain is involved in mediat- ing protein–protein interactions, the LRRK2 G2385R variant may impact on interactions with substrates and ⁄ or regulatory proteins. Preliminary ... MINIREVIEW LRRK2 in Parkinson’s disease: genetic and clinical studies from patients Udhaya Kumari 1,2 and E. K. Tan 1,2 1 Department of Neurology, Singapore General Hospital...

Ngày tải lên: 23/03/2014, 04:20

... proteins, PFK2, TDH3, GPM1 and -3, ENO2, PDC5 and ADH6 showed interaction with the yeast E3 ubiquitin ligase RSP5 in a binding assay using protein chips [44]. For PFK, GPM, PDC and ADH this is in ... ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin pro- tein ligase (E3). E3 ubiquitin ligase binds directly to the substrate proteins and thereby reg...

Ngày tải lên: 18/02/2014, 06:20

... and (S)-4-AHCP (including atom numbering as in pdb-file). GluR2 ligand-binding core in complex with (S)-4-AHCP B. B. Nielsen et al. 1640 FEBS Journal 272 (2005) 1639–1648 ª 2005 FEBS binding and ... seven-membered ring system; this residue is replaced by the smaller Ser721 in GluR5. Homology modelling of the ligand-binding core of GluR5 and docking of (S)-4-AHCP to this model has s...

Ngày tải lên: 30/03/2014, 16:20