Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc

... MINIREVIEW LRRK2 in Parkinson’s disease: function in cells and neurodegeneration Philip J. Webber and Andrew B. WestDepartment of Neurology, Center for Neurodegeneration and Experimental ... but in concert with anumber of conserved domains, including a GTPasedomain. Multidomain proteins that encode functionalkinase domains often utilize intrinsic protein kinaseactivity distinct ... mitogen-activated protein kinase; MAPKK, MAPK kinase; MLK, mixed-lineage kinase; PD, Parkinson’s disease; RIP1, receptor-interactingserine ⁄ threonine kinase-1; ROC, Ras of complex proteins; TRADD, tumor...

Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc

... mitochon-dria into the cytosol through inactivation with Bcl-xL and Bcl-2 [69]. Inactivated Bax and Bad bind 14-3-3,the phosphoserine ⁄ threonine binding proteins in thecytosol. 14-3-3 prevents Bax and ... and probably its close paralog cas-pase-10 [46]. Pro-caspases exist in living cells and casp-ases are indispensable for the proliferation of some celllines. When deciding between maintaining ... 433okadaic acid (OA) and protein kinase inhibitor stauro-sporine (ST) are typical inhibitors that promote celldeath. Both inhibitors increase MAPK-involved celldeath signaling leading to caspase...

Tài liệu Báo cáo khoa học: "Archivus: A multimodal system for multimedia meeting browsing and retrieval" doc

... speciﬁc domain.1 Introduction In the past few years, there has been an increasinginterest in research on developing systems for efﬁ-cient recording of and access to multimedia meet-ing data1. ... user input from all modalities(speech, typing and pointing) and provides mul-timodal responses in the form of graphical, textual and vocal feedback.The dialogue manager contains only linguisticknowledge ... http://www.icsi.berkeley.edu/Speech/EARS/rt.htmltry out and consistently use novel input modalitiessuch as voice, including more complex natural lan-guage, and that in particular in this domain, suchmultimodal interaction can help...

Báo cáo khoa học: "Scaling up from Dialogue to Multilogue: some principles and benchmarks" doc

... subsequent investigations of multilogueinteraction.Information States We assume information states ofthe kind developed in the KoS framework (e.g. (Gin-zburg, 1996, forthcoming), (Larsson, 2002)) and ... increasedincidence and increasing active participantsize. We plan to carry out more detailed work, bothcorpus–based and experimental, in order to evaluate thestatus of MAG and, correspondingly ... leads in particular to the fol-lowing two benchmarks protocols for querying, assertion, and grounding interaction in multilogue:(5) a. Multilogue Long Distance short answers(MLDSA): querying...

Báo cáo khoa học: The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway pdf

... examinedthat had arginine in this position may, in fact, representGMDs. We are currently working to test experimentallywhether exchange of arginine and glutamine at thisposition can interconvert ... aeruginosa isolates, and is maintained on the cell surface in chronic infec-tions. A-band O polysaccharide is apparently immuno-logically invisible to the host in the initial stages ofinfection, ... the sugar nucleotide-modifying SDR family, folding into two domains: aRossmann fold domain, which binds cofactor, and amixed a/b domain, which binds substrate and conferssubstrate nucleotide...

Báo cáo khoa học: Functional dissection of two Arabidopsis PsbO proteins PsbO1 and PsbO2 doc

... Shen JR, Inoue Y & Sherman LA(1994) Role of disulﬁde linkage and putative intermole-cular binding residues in the stability and bindingof the extrinsic manganese-stabilizing protein to thephotosystem ... Yocum CF(1994) Role of disulﬁde linkage and putative intermole-cular binding residues in the stability and binding of theextrinsic manganese-stabilizing protein to the photosys-tem II reaction ... deleted using genetic methods in cyanobacteria[6,7] and in green algae [8], and such mutants havebeen maintained under heterotrophic conditions. In contrast, no PsbO mutant has been obtained in higherplants...

Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf

... FEBSMINIREVIEW LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic rolesZhenyu YueDepartment of Neurology and Neuroscience, Mount Sinai School of Medicine, ... illustration of domain structures and alignment for LRRK2 and LRRK2 structure-related proteins. ANK, N-terminal ankyrinrepeat domain; DEP, Dishevelled, EGL-10, pleckstrin domain; GEF, guanine-exchange ... pro-teins (e.g. ROCO family proteins) in various modelsystems, including lower eukaryotes and invertebrates, in order to obtain clues for building important hypoth-eses. The rapidity and efﬁciency...

Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt

... WD40domain. Because WD40 domain is involved in mediat-ing protein–protein interactions, the LRRK2 G2385Rvariant may impact on interactions with substrates and ⁄ or regulatory proteins. Preliminary ... MINIREVIEW LRRK2 in Parkinson’s disease: genetic and clinicalstudies from patientsUdhaya Kumari1,2 and E. K. Tan1,21 Department of Neurology, Singapore General Hospital, Singapore, Singapore2 ... multidomain protein comprising (fromN-terminal to C-terminal), armadillo (ARM), ankryn(ANK), LRR, Ras of complex proteins (ROC), C-ter-minal of ROC (COR), mitogen-activated proteinkinase kinase kinase...

Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc

... proteins,PFK2, TDH3, GPM1 and -3, ENO2, PDC5 and ADH6 showed interaction with the yeast E3 ubiquitinligase RSP5 in a binding assay using protein chips [44].For PFK, GPM, PDC and ADH this is in ... ubiquitin-activating enzyme (E1),ubiquitin-conjugating enzyme (E2) and ubiquitin pro-tein ligase (E3). E3 ubiquitin ligase binds directly tothe substrate proteins and thereby regulates the speci-ﬁcity ... We did observe anincrease in the TDH1 mRNA level, encoding one ofthe GAPDH isoenzymes, in line with earlier reports ofinduction of this transcript in heat-shocked cells and under glucose starvation...

Báo cáo khoa học: Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP potx

... and (S)-4-AHCP(including atom numbering as in pdb-ﬁle).GluR2 ligand-binding core in complex with (S)-4-AHCP B. B. Nielsen et al.1640 FEBS Journal 272 (2005) 1639–1648 ª 2005 FEBSbinding and ... seven-memberedring system; this residue is replaced by the smallerSer721 in GluR5.Homology modelling of the ligand-binding core ofGluR5 and docking of (S)-4-AHCP to this model hasshown that the binding ... differences in the ligand-binding site between GluR2 and GluR5are the respective substitutions of Leu650 and Met708 in GluR2 to the smaller residues Val685 and Ser741 in GluR5 (numbering as in TrEMBL entry...

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