Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc

... An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein Tomoji Maeda 1 , Toshihiro Marutani 2, *, ... directly interacting with the sub- strate proteins and helping to transfer ubiquitin to them. Therefore, to determine whether NCT is the substrate of Synovi...

Ngày tải lên: 23/03/2014, 04:20

... substantial amount of train- ing, including the reading of coding instructions for the two versions of the scheme (6 pages for the basic scheme and 17 pages for the full scheme), four training ... We wish to thank our annotators, Vasilis Karaiskos and Ann Wilson, for their patience and diligence in this work, and for their insightful, crit- ical, and very u...

Ngày tải lên: 22/02/2014, 03:20

... in2 Improvement of Automatic Indexing by Syntactic Analysis in3 Improvement of Automatic Indexing by Semantic Approaches in4 Probabilistic Methods of Indexing in5 Indexing Functions in6 ... second round are in general higher than in the first one. This is an argument against the oft cited Delphi hypothesis that the feedback-mechanism - i.e. that the data of...

Ngày tải lên: 17/03/2014, 19:21

... none of the linguistics in this section follows from the system. The aim of the discussion is to give an idea of the power of the anaphoric component and of the kinds of linguistics that can ... between the I-structures ANT and ANA when one of ANT's sisters is ANA's ancestor. The MiMo defini- (18) c_command(Ant,Ana) :- sister(Ant,X),...

Ngày tải lên: 18/03/2014, 02:20

... (NE) since anglicisms representing other parts of speech are relatively infrequent in German (Yeandle, 2001). Tokens were looked up twice, in the German and the English database and parts of hyphenated ... train- ing on the internet and testing on the space travel data, and CD2, training on the space travel and test- ing on the internet data. We chose these two d...

Ngày tải lên: 23/03/2014, 19:20

... from the English side of the corpus. In- stances of the English collocation are found and the mutual information is calculated between the instances and various single word candidates in aligned ... and R. L. Mercer. Analysis, statistical transfer, and synthesis in machine translation. In Proceedings of the Fourth International Conference on The- ore...

Ngày tải lên: 31/03/2014, 06:20

... (FR ⁄ YA). The asterisk (*) marks the histidine residue involved in covalent binding of the FAD cofactor in GUO, ALO and GLO. The FAD-binding domain [2] is underlined. N. G. H. Leferink et al. ... the Netherlands l-Ascorbic acid (vitamin C) is an important antioxi- dant, redox buffer and enzyme cofactor for many organisms. Plants and most animals can synthesize l...

Ngày tải lên: 23/03/2014, 07:20

... On the other hand, the synthesis of pro-b-conglycinin was ini- tiated when the seeds achieved a mass of 40 mg. The synthesis of pro-b-conglycinin increased until the seeds grew to 70 mg and then ... equivalent to the synthesis levels of both b-conglycinin and glycinin. The synthesis of proglycinin was initiated when the seeds achieved a mass of 50 mg, and inc...

Ngày tải lên: 23/03/2014, 09:21

... zebrafish RPE65a and RPE65c. Fig. S2. Immunostaining of zebrafish retinal section using antibodies for GS and RPE65c. Fig. S3. Hypothesized molecular mechanisms of the in vitro assay system and the intra-retinal ... and retinoid-binding pro- teins between photoreceptors and retinal pigment epi- thelium (RPE); it is essential for maintaining normal vision [3,4]. The key s...

Ngày tải lên: 14/02/2014, 14:20

... shock and multiorgan failure [3–6]. The role of LeTx in anthrax pathogenesis is complex, however, and probably involves the impairment of the innate and adaptive immune responses in a number of ... Medicine and Pathobiology, University of Toronto, Canada Introduction Bacillus anthracis lethal toxin (LeTx) is a binary toxin that is released by the bacterium du...

Ngày tải lên: 16/02/2014, 09:20