Báo cáo khoa học: Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates potx

... Journal compilation ª 2009 FEBS Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates Anton P. Bussink 1 , Marri Verhoek 1 , Jocelyne ... chitin- binding domain, a hinge region and a 39 kDa catalytic domain in which enzymatic activity resides [13]. The enzyme is secreted into the circulation as 50 kDa pro...

Ngày tải lên: 23/03/2014, 04:20

... tagging. 4 Machine learning components in Argo In order to ensure flexibility in building workflows, we split the machine learning capability into three distinct processing components, namely feature ... visible in the middle of Figure 1. 122 (a) Training (b) Tagging Figure 2: Two generic workflows demonstrating the use of the Feature Generator component for (a) training and (b) tagging....

Ngày tải lên: 16/03/2014, 20:20

... to distin- guish the types depending on whether an information or information sharin~ interaction zs involved. C interaction is przmarily information seeking, although some sharing interaction ... which have more of ~ining function. Training in- volves more of information sharing, while service in- volves more of providing infornmtion requested by the user. 2. Information about t...

Ngày tải lên: 17/03/2014, 19:20

... be most effective in improving chunking results. Indeed, our experi- ments show that introducing morphological fea- tures improves chunking quality by as much as 3-point in F-measure when compared ... errors: bracketing [a][b] instead of [a b] Merge errors: bracketing [a b] instead of [a][b] Short errors: bracketing “a [b]” or “[a] b” in- stead of [a b] Long errors: bracketing “[a...

Ngày tải lên: 23/03/2014, 18:20

... embedding each of these examples in a context that reinforces one of the meanings. For instance, gapping is felicitous in passage (3), where con- text supports the symmetric reading, but is infelicitous ... felicitous in these cases. This account also explains similar differences in fe- licity for other coordinating conjunctions as discussed in Kehler (1994), as well as why gapp...

Ngày tải lên: 08/03/2014, 07:20

... data). In addition to the b 2 GPI quantitative polymorphisms, we have originally described a common protein polymorphism in the b 2 GPI gene [39] and both polymorphisms were found to be tightly linked ... measured using the Bio-Rad Protein Assay Kit (Bio-Rad Laboratories, Hercules, CA, USA) according to the manufacturer’s instructions. Bovine serum albumin was used as standard to dete...

Ngày tải lên: 31/03/2014, 07:20

... followed their own definitions of different scoring values, such as excluding certain scores (see examples in table 1). They find the def- initions incorrect. If the veterinarian strictly follows ... observations regarding Table 1: Table of metritis score definitions and examples of present usage in practice. Scores Clinical signs - vaginal examination Cases Practical scoring Decision mak...

Ngày tải lên: 25/10/2012, 10:45

... GS staining (B3), and 4¢,6-diamidino-2-phenylindole (DAPI) staining (B4), respectively. (B5-8) High magnification images of the boxed area in (B4) showing RPE65c staining (B5), GS staining (B6), ... enzymes and retinoid-binding pro- teins between photoreceptors and retinal pigment epi- thelium (RPE); it is essential for maintaining normal vision [3,4]. The key step in the retinoid visual c...

Ngày tải lên: 14/02/2014, 14:20

... protein kinase; MCF, macrophare chemotactic factor; MCIP, modulatory calcineurin-interact- ing protein; MDCK, Madin Darby canine kidney; MEF, mouse embryonic fibroblast; MEK, MAP kinase/ERK kinase; ... glycogen synthase) is insufficient to accurately explain insulin-stimulated changes in the concentration of intracellular species and partitioning of glucose disposal in skeletal muscle. Insu...

Ngày tải lên: 14/02/2014, 14:20

... have anti -in ammatory activity. Since 2006, several patients carry- ing a fusion protein, originating from a translocation joining genes encoding the kinases ITK and spleen tyrosine kinase (SYK), ... signaling proteins carrying domains also found in BTK. In 2009, an inactivating mutation in the ITK gene was shown to cause susceptibility to lethal Epstein–Barr virus infec- tion. Both k...

Ngày tải lên: 14/02/2014, 18:20