Báo cáo khoa học: Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma pot

... S100A9 and LASP-1 may play an important role in the development and progression of CRC. Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the ... role in the progression and metastasis of CRC. In summary, the techniques of proteomic analysis provide a dramatic means of screening for genesis- and...

Ngày tải lên: 23/03/2014, 03:20

... performed with this preparation. The 1 H NMR chemical shifts and the grouping of the signals in pairs (one pair at d H 3.30 and 3.19, and the other at d H 3.03 and 2.95; see below) resembled those of ... between the LPS of wild-type R C1 and phase variant 811 [ 24] or between the L PS of the avirulent wild-type 5097 and the corresponding mutant 137 [17]....

Ngày tải lên: 08/03/2014, 10:20

... cells with developmental potentials that are indistinguish- able from that of the mother cell. This process is cen- tral to development, as well as to the maintenance of adult tissues in complex and ... cells (Fig. S1). On the other hand, the northern blotting and quantitative real-time PCR analysis also showed that the expression of differentiation marker genes such...

Ngày tải lên: 07/03/2014, 00:20

... Seg C and SegTag L are the predictions of the three coarse- grained solvers. For the three words at the begin- ning and the two words at the end, the three predic- tors agree with each other. And these five ... the reference of previous systems that represent state -of -the- art results. The comparison of the accuracy between our stacked sub-word system and...

Ngày tải lên: 17/03/2014, 00:20

... ifference i n the internal ¯exibility of t he molecules. The rigid nature of the second b strand is consistent with the presence of the indole r ing of Trp25 bridging strands 1, 2 and 3. It should ... and and in the 20±25 loop, as well as in the P2¢ and P 3¢ positions of the binding loop. The residues with the greatest Dd NH values are Thr16 and, more...

Ngày tải lên: 08/03/2014, 10:20

... hypothesis in a local neighborhood of the current-best hypothesis, leading to a much more ef- ficient algorithm in terms of the number, N, of hy- potheses evaluated (Rastrow et al., 2011b); the ... accuracy of 97.2% on BN. We train the syntactic discriminative LM, with head-word and POS tag features, using the faster parser and tagger and then rescore the ASR hypoth...

Ngày tải lên: 16/03/2014, 19:20

... vascu- lar tissue of cotyledons and mature leaves, whereas, in the flowers, the anthers, connectives and filaments and the base and tip of the stigmata were stained. Similar to BPM2, BPM3 and BPM5 promoter:GUS ... cotyledons and in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were stained in the vascular...

Ngày tải lên: 18/02/2014, 06:20

... may affect the metabolism of the target cells in more ways than just the therapeutic purpose of the introduced gene. The normal function of nucleoside kinases is to provide the cells with deoxyribonucleo- tides ... : 4 in these cells. In the presence of exogenous dNs, the Dm-dNK expressing H9 cells showed a significant increase of 10- and sixfold of the dTTP p...

Ngày tải lên: 20/02/2014, 01:20

... function of the kinetic constants of the enzymes involved in that pathway [3]. Application of this method pointed to the inhibition of the rate of synthesis of ATP by the glycolytic route as a potential ... with H 2 O 2 , which produced a decrease in both the consumption of glucose and synthesis of ethanol. The apparent effect of H 2 O 2 on glycolysis was f...

Ngày tải lên: 17/03/2014, 10:20

... chaperone therapy. Synthesis of proteins takes place at ribo- somes, and newly synthesized proteins are secreted to the lumen of the ER. The ER has developed a ‘quality-control system’ to ensure the full ... proteins from reentering the refolding process, and serves as a signal for targeted ERAD. Inhibition of ER a-mannosidase I often delays the degradation of gl...

Ngày tải lên: 30/03/2014, 03:20