Báo cáo khoa học: The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation pptx
Báo cáo khoa học: The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation pptx
... invertebrate Caenorhabditis elegans, two of the three enzymes of reductive pyrimidine degradation havepreviously been characterized. The enzyme catalysing the final step of pyrimidine breakdown, 3-ureidopropionase ... overdosing[16,17]. In the genome of the nematode Caenorhabditis ele-gans, only the reductive pathway (and none of the alternative routes) is present. The first two enzymes of reductive pyrimidine degradation ... 3-ureidopropionase is involved in the synthesis of the pantothenate moity of coenzyme Aand 3-aminopropionate can serve as osmoprotectant[9]. Those different roles in metabolism might beresponsible for the observed...
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Báo cáo khoa học: The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides pot
... as the ODN h ybridizes to the center of the input target RNA. The asterisk indicates the input targetRNA; the arrow indicates the digested product bands. The amount of digested product obtained ... To investigate the nature of the differences in response t o a ntisense ODNs we analyzed the RNase H levels in the cell lines, as RNase H is claimed to be a keycomponent in the mechanism of inhibition ... compartmentaliza-tion of a component in the in vivo system. On the otherhand, we cannot exclude the possibility that the substantialamount of 5.5-kb mRNA present in all cells encodes amajor contributor of the...
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Báo cáo khoa học: "The effect of domain and text type on text prediction quality" pptx
... Twitter and Facebook updates) are of a dif-ferent style and lexicon than documents typed in of ce software (Westman and Freund, 2010). In addition, the topic domain of the text also in u-ences ... questions and evaluating on the re-maining questions). The prospective application of the third series of experiments is the development of a text predic-tion algorithm in an online care platform: an ... the query ‘faq’with the language restriction Dutch. After clean-ing the pages from HTML and other coding, the resulting corpus contained approximately 1.7 Mil-lion words of questions and answers.4.2...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... metalloproteinases in vitro and eliminates pro-duction of avb3 integrin, a protein missing in normalmelanocytes but often manufactured during the inva-sive phase [141]. Hsp27 over expression in melanomacells ... activity and packing, magnifying the consequences of these changes and promoting cataractformation more than anticipated.Evidence linking cataract and a-crystallin post-trans-lational changes ... demonstrating the protein’s importance in cell maintenance [149]. sHSPs prevent aggregation of oxidized and damaged proteins as organism’s age,extending life-span and delaying disease onset [150].These...
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Báo cáo khoa học: Structural basis of p63a SAM domain mutants involved in AEC syndrome ppt
... with other SAM domains or by interactingwith other proteins [23]. The SAM domain of the pro-tein Smaug, however, has been shown to participate in RNA binding [24,25]. The exact role of p63a andp73a ... of these mutations can be seen in Fig.3.To analyse the effect of these mutations, the p63aSAM domain containing some of the point mutationsabove were cloned and expressed. The expression of point ... furthersupported by mutations occurring in the p63 SAMdomain resulting in the activation of Hsp70.Mutations can inactivate a protein either by alteringfunctionally important residues or by the...
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Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx
... alsopresent in the HNF1b protein. Depending on the splicevariant, there is a 26 aa insertion between the POUSandPOUHdomain in the HNF1b protein. This variant is found in mammalian and also ... proteins. Boxes include 75% of the values,and the vertical line represents the group median, and whiskers represent the outer quartile. The P-value calculated using the Mann–Whitney testand the ... structural ana-lysis of the HNF1a protein indicates that the POUSdomaininteracts with the 21 aa loop of the POUHdomaintocreatea stable in terface between the two DNA binding domains.This...
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Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx
... also included 17 selected insect hexamerins, 23crustacean hemocyanins, 4 crustacean pseudohemocyanins,20 chelicerate hemocyanins, 5 myriapod hemocyanins and1 onychophoran hemocyanin in the ... insect hex-amerins, crustacean hemocyanins, crustacean pseudohemocyanins, chelicerate hemocyanins, myriapod hemocyanins and one onychophoranhemocyanin. The onychophoran hemocyanin (EpiHc1) was ... TdoHc2 and LsaHc2). We also includedselected insect hexamerins, crustacean hemocyanins,crustacean pseudohemocyanins, chelicerate hemocya-nins, myriapod hemocyanins and one onychophoranhemocyanin...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... thought to be determined by a number of fac-tors, including the rate of unfolding, the amino acidsequence of the protein, the experimental conditionsand the nature of the intermediate state(s) ... increase the activity of aB-crystallin against DTT-induced precipi-tation of insulin at intermediate and high concentra-tions, and it also increased the activity of aB-crystallin in preventing the ... interact with a number of functionalgroups, including the aromatic side chains of someamino acids, through a stacking mechanism [42]. The interaction of arginine with aromatic amino acids of aB-crystallin...
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Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx
... 2008)doi:10.1111/j.1742-4658.2008.06522.x The folding of eukaryotic DNA into the 30 nm fibre comprises the firstlevel of transcriptionally dormant chromatin. Understanding its structureand the processes of its folding and unfolding ... crosslinking of nucleosomes and digestion of the DNA to mononucleosome size of samples con-sisting of a mixture of hepta-, octa- and nonanucleosomes and half the amount of hexa- and decanucleosomes ... nucleosomes in the mainpeak, indicates that crosslinking is almost complete in the middle of the fibre, but some of the end-nucleo-somes are not crosslinked to the rest and thereforemust originate...
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![Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx](https://media.store123doc.com/images/document/14/br/gc/small_Y97X8XlBli.jpg)
Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx
... the binding affinity wasobserved in the case of binding of the M.HhaI with the X+CG ⁄ CGM duplex containing the (+)-cis-B[a]P-N2-dG adduct on the 5¢-side of the target dC residue. The binding ... M.HhaIconsists of two domains, the large domain containing the S-adenosyl-l-methionine (AdoMet) binding siteand the catalytic center, and the small domain contain-ing the target recognition domain (Fig. ... with the intercalativeconformation of the (+)-cis adduct and the minor-groove conformation of the (+)-trans adduct, the lat-ter interfering with interactions of the catalytic loops of the MTases...
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