Báo cáo khoa học: The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation pptx

... invertebrate Caenorhabditis elegans, two of the three enzymes of reductive pyrimidine degradation have previously been characterized. The enzyme catalysing the final step of pyrimidine breakdown, 3-ureidopropionase ... overdosing [16,17]. In the genome of the nematode Caenorhabditis ele- gans, only the reductive pathway (and none of the alternative rou...

Ngày tải lên: 23/03/2014, 03:20

... as the ODN h ybridizes to the center of the input target RNA. The asterisk indicates the input target RNA; the arrow indicates the digested product bands. The amount of digested product obtained ... To investigate the nature of the differences in response t o a ntisense ODNs we analyzed the RNase H levels in the cell lines, as RNase H is claimed to be a key c...

Ngày tải lên: 08/03/2014, 10:20

... Twitter and Facebook updates) are of a dif- ferent style and lexicon than documents typed in of ce software (Westman and Freund, 2010). In addition, the topic domain of the text also in u- ences ... questions and evaluating on the re- maining questions). The prospective application of the third series of experiments is the development of a text predic- tion algorit...

Ngày tải lên: 17/03/2014, 22:20

... metalloproteinases in vitro and eliminates pro- duction of avb3 integrin, a protein missing in normal melanocytes but often manufactured during the inva- sive phase [141]. Hsp27 over expression in melanoma cells ... activity and packing, magnifying the consequences of these changes and promoting cataract formation more than anticipated. Evidence linking cataract and a-crystallin...

Ngày tải lên: 19/02/2014, 18:20

... with other SAM domains or by interacting with other proteins [23]. The SAM domain of the pro- tein Smaug, however, has been shown to participate in RNA binding [24,25]. The exact role of p63a and p73a ... of these mutations can be seen in Fig.3. To analyse the effect of these mutations, the p63a SAM domain containing some of the point mutations above were cloned and...

Ngày tải lên: 22/03/2014, 16:20

... also present in the HNF1b protein. Depending on the splice variant, there is a 26 aa insertion between the POU S and POU H domain in the HNF1b protein. This variant is found in mammalian and also ... proteins. Boxes include 75% of the values, and the vertical line represents the group median, and whiskers represent the outer quartile. The P-value calculated using th...

Ngày tải lên: 23/03/2014, 13:20

... also included 17 selected insect hexamerins, 23 crustacean hemocyanins, 4 crustacean pseudohemocyanins, 20 chelicerate hemocyanins, 5 myriapod hemocyanins and 1 onychophoran hemocyanin in the ... insect hex- amerins, crustacean hemocyanins, crustacean pseudohemocyanins, chelicerate hemocyanins, myriapod hemocyanins and one onychophoran hemocyanin. The onychophoran hemocyanin (EpiHc1) wa...

Ngày tải lên: 18/02/2014, 08:20

... thought to be determined by a number of fac- tors, including the rate of unfolding, the amino acid sequence of the protein, the experimental conditions and the nature of the intermediate state(s) ... increase the activity of aB-crystallin against DTT-induced precipi- tation of insulin at intermediate and high concentra- tions, and it also increased the activity of...

Ngày tải lên: 18/02/2014, 16:20

... 2008) doi:10.1111/j.1742-4658.2008.06522.x The folding of eukaryotic DNA into the 30 nm fibre comprises the first level of transcriptionally dormant chromatin. Understanding its structure and the processes of its folding and unfolding ... crosslinking of nucleosomes and digestion of the DNA to mononucleosome size of samples con- sisting of a mixture of hepta-, octa- an...

Ngày tải lên: 18/02/2014, 18:20

... the binding affinity was observed in the case of binding of the M.HhaI with the X + CG ⁄ CGM duplex containing the (+)-cis-B[a]P- N 2 -dG adduct on the 5¢-side of the target dC residue. The binding ... M.HhaI consists of two domains, the large domain containing the S-adenosyl-l-methionine (AdoMet) binding site and the catalytic center, and the small domain con...

Ngày tải lên: 19/02/2014, 00:20