Báo cáo khoa học: Making sense of G-quadruplex and i-motif functions in oncogene promoters pot

... poses interesting compu- tational and linguistic challenges. For instance, we need to handle the noise inherent in matching based on acoustic similarity, because of possible varia- 504 tions in ... (SD) models and the other ob- tained using speaker-independent (SI) models. The speaker-independent model was trained on 85 hours of out -of- domain general lecture material and con-...

Ngày tải lên: 17/03/2014, 04:20

... II NM23-H2 5′ 3′ 3′ 5′ OFF ABC E D 5′ 3′ 3′ 5′ OFF Fig. 5. Cartoon showing the involvement of NM23-H2, nucleolin and a G-quadruplex- interactive compound in modulating the activation and silencing of the NHE III 1 in ... contaminat- ing protein that is either an accessory protein or a minor recombinant protein [34]. Studies show that an R88A mutation (arginine to alanine) in th...

Ngày tải lên: 23/03/2014, 03:20

... sentence in those reviews collected from each domain with the features described in Section 3.1. We divided the data for training and testing. We then trained our model using the training set and ... set of pro and con sentences in online reviews using clue phrases for pros and cons in epinions.com in order to train our system. We applied it to label sentences both o...

Ngày tải lên: 20/02/2014, 12:20

... analysis of protein spots was performed by matching corresponding spots across different gels. Each of the matched protein spots was rechecked manually. Intensity volumes of individual spots were ... overexpression of enolase 1 and malic enzyme 1 supports the induction of fatty acid metabolism. The reduction in d-amino acid oxi- dase 1 expression in the kidney proteome is inte...

Ngày tải lên: 23/03/2014, 03:20

... dopamine treatment, overexpres- sion of a-synuclein significantly affected the levels of four proteins [stathmin 1, glutathione S-transferase (GST)p, Ran 1 binding protein and C1q binding pro- tein], ... suggested to be linked to early stages of PD pathogenesis [26]. Interestingly, in our model, dopamine induces an increase of the actin bundles regulator fascin 1 [27] and discord...

Ngày tải lên: 15/02/2014, 01:20

... important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining stable phenotypes. We would argue that a single ... time-consuming and greatly in uenced by individual handlers. IntelliCages are automated learning cages where animals carrying transponders are housed in groups and trained in...

Ngày tải lên: 16/02/2014, 09:20

... contribute to in amma- tory injury. Taurine may offer an advantage in because of it increase the reduced L-arginine/ADMA ratio. Thus, taurine pro- tects cells from in ammatory injury resulting from ... its interaction with NF-jB, result- ing in reduction of the DNA binding activity of NF-jB. We found a putative NF-jB binding site (core binding sequence GGGACTTT) in the promoter...

Ngày tải lên: 19/02/2014, 07:20

... mice have an increased incidence of systemic lupus erythematosus (SLE), with classical findings including the presence of autoreactive antibodies and glomerulonephritis occurring in a DNase I-level-dependent manner; ... previously. Proteins were determined using a protein assay kit (Bio- Rad) with BSA as a standard. SDS/PAGE was performed in 12.5% (w/v) gels according to the method...

Ngày tải lên: 19/02/2014, 16:20

... formation of quinonoid intermediates (Scheme 1). In the holoenzymes (E) the cofactor PLP is bound in the active site as an Ôinternal aldimineÕ with an e-amino group of a definite lysine residue. ... groups of amino acid inhibitors mentioned above. The interaction of L -phenylalanine, L -methionine, and their a-deuterated analogs with TPL in D 2 O was charac- terized by the appe...

Ngày tải lên: 19/02/2014, 16:20

... (yellow) and tACE (white). (A) Binding site of CL1 in ACE2 and tACE; (B) binding site of CL2 in ACE2 and tACE. Residue numbering for ACE2 is first. The chloride ion is green and the zinc ion is ... the substitution of Pro407 and Pro519 in ACE for Glu398 and Ser511 in ACE2. The side chains of Glu398 and Ser511 project into the loca- tion of the chloride ion-bindi...

Ngày tải lên: 20/02/2014, 01:20