Báo cáo khoa học: The molecular identity of the mitochondrial Ca2+ sequestration system potx

... the projection of the tilt of the z axis on the x¢,y¢ plane (defined direction of tilt of z and the x¢ axis), and j % a + c defines the location of the rhombic (x, y) axes. The orientation of the ... at position E7 as the source of the H-bond to ligand on the basis of a partial sequence, which had indicated a Tyr on the distal E-helix. The similarity...

Ngày tải lên: 23/03/2014, 17:22

... presence of alternative splicing around the 5¢-end of exon 6 of Meis2 and Meis3 was tested by RT-PCR. The positions of molecular mass markers are shown to the left, and the size in base pairs of the ... However, the activity of the full-length Meis1a was not tested, and on the basis of our work we expect that its activity would be inhibited by the conserved H...

Ngày tải lên: 16/02/2014, 15:20

... advantage of p53 mutation analysis, and a unique feature of this database, is the availabil- ity of the residual activity of the majority of p53 mis- sense mutants. The biological activity of mutant ... of a severe mutant. At the other end of the spectrum, where we have low energy, there is 75% probability for the mutation to be nonsevere if the energy is 0.125...

Ngày tải lên: 18/02/2014, 11:20

... obtained with the transition at posi- tions 1915 and 1917. These mutations had an effect on the formation of pseudouridine exclusively at the mutant position and did not affect either of the other two ... by Southern analysis. The rluD::cat strain had a full deletion of both rluD and yfiH, together with their annotated pro- moter sequences. The inserted cat cassette had a dis...

Ngày tải lên: 18/02/2014, 16:20

... Given that the roles of these residues definitely confirm each other, the dif- ference in their significance might be attributable to the importance and ⁄ or necessity of the receipt of the phenol-hydroxyl ... environments of BPA in the ligand-binding pocket of the ERRc. The proximity of each amino acid residue (within a distance of 5 A ˚ ) to BPA is shown in the...

Ngày tải lên: 18/02/2014, 16:20

... each extremity of the polypeptide chain, must of necessity arise from contacts that are made outwith the active site of the enzyme. The effect of removal of the N-terminal extension The full N-terminal ... binding of this helical N-terminal seg- ment of IA 3 . The E + I « EI balance thus lies far to the right and the addition of further residues at the N-te...

Ngày tải lên: 19/02/2014, 00:20

... less sensitive to the pres- ence of the anion. These residues also modulate the conformation of unfol- ded cytochrome c, influencing its spin state and the coordination to the prosthetic group. Abbreviation CT, ... effect of Cl – reflects the different affinities of the two anions for the protein [11,17]. We also monitored the effect of sulfate on the perchlorate-in...

Ngày tải lên: 19/02/2014, 05:20

... on, the addition of a small amount of a QAE1 isoform, nfeAFP8 (Fig. 7). This is similar to the case of the QAE2 isoform, nfeAFP13; the activity of its monomer was enhanced by the pres- ence of ... sequence alignment of nfeAFPs The complete amino acid sequences of the 13 isoforms of nfeAFP were determined based on the cDNA A B Fig. 2. (A) HPLC purification of...

Ngày tải lên: 19/02/2014, 16:20

... in terms of the number of the enzymes involved, the kinetic mechanisms of the competing enzymes and the number as well as the nature of the allosteric controls. Whether such diversity in the organization ... changes in the concentration of P i do not modify the partition (Fig. 3A). However, the presence of P i considerably affects the dynamics of the s...

Ngày tải lên: 20/02/2014, 02:21

... extraction (IE) harder when learning the individual types of part-whole relations? That is, we determine whether the performance of state -of -the- art IE systems in learning the individual part-whole relation types ... were discarded. The precision of the tuples discovered by the different seed-sets in the last iteration of our algorithm are in Table 3. These results r...

Ngày tải lên: 20/02/2014, 04:20