Báo cáo khoa học: The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of b-glucosidase docx

... Therapeutics. Journal compilation ª 2010 FEBS The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of b-glucosidase Richie Khanna 1 , Elfrida R. ... wild-type human GCase activity in vitro [25]. The ability of IFG to cross the blood–brain barrier and to increase the activity of L444P GCase enc...

Ngày tải lên: 22/03/2014, 21:20

... human cells may affect the metabolism of the target cells in more ways than just the therapeutic purpose of the introduced gene. The normal function of nucleoside kinases is to provide the cells with ... shown). In order to test the enzymatic activity of the Dm-dNK–GFP fusion protein and the level of nucleo- side kinase activity in the cells, we determined t...

Ngày tải lên: 20/02/2014, 01:20

... to the discovered themes. Finally, the V-matrix relates the original sentences to each of the themes. The point of the SVD analysis is to discover these themes based on co-variance between the ... differ- ent assumption about the nature of the reading con- text. Instead of taking the anchor text as an indicator of the user’s information need, it assumes that t...

Ngày tải lên: 20/02/2014, 09:20

... understanding of system capa- bilities. Of the remaining 66% of inputs (2166) which were within the functionality of the system, 68% were in grammar. On the within functionality portion of the data, the ... sets of scenarios and then freely interacting with each system. For counterbalancing purposes, half of the subjects used the tablet and then the re- mo...

Ngày tải lên: 20/02/2014, 12:20

... 1.6808 0.6612 Y= the first right brother of the current node 0.4730 1.1525 0.7502 Y= the first left brother of the current node 0.5832 2.1511 1.2186 Y= the second right brother of the current node ... 0.5044 0.2525 Y= the second left brother of the current node 0.0949 0.6171 0.2697 Y= the first right brother of the parent 0.1068 0.3717 0.2133 Y= the first left...

Ngày tải lên: 20/02/2014, 18:20

... if the actions of the CHH neuropeptides on repression of ecdysteroid synthesis by the Y-organ (YO) are considered. The most widely accepted paradigm of moult control in crustaceans concerns the ... levels in the XO, and peptide levels in the SG during these significant stages of the moult cycle, as these are of fundamental importance with regard to the currently acc...

Ngày tải lên: 21/02/2014, 00:20

... independently of each other (one on the basis of the possible Eng- lish questions about the subject-domain, the other on the basis of the structure of the data base about it) there must be ... items of English. The prim- itives of the lowest semantic level are the prim- itives of the data base (names of files, attributes, data-items). The formal...

Ngày tải lên: 21/02/2014, 20:20

... effect (Fig. 4C). In the case of L-ficolin, the interaction with CD91 was abolished in the presence of EDTA, but the presence or absence of Ca 2+ ions in the buffer had no effect on the interac- tion ... Like MBL and the ficolins they are pattern-recognition molecules but do not share the property of binding the MASPs and therefore do not activate the complement casc...

Ngày tải lên: 06/03/2014, 01:23

... PARP-1-dependent derangement of the integrity of the neurovascular unit is caused by the enzyme’s ability to prompt an increase of blood– brain barrier (BBB) permeability, the release of pro- inflammatory ... occlusion [41]. The key role of PARP-1 hyperactivation in endo- thelial dysfunction in experimental models of diabetes underscores the pathogenetic relevance of...

Ngày tải lên: 07/03/2014, 03:20

... analysis of initial rate data in the absence of inhibitors, we used the specific equation in Scheme 1. The effect of two ligands on the activity of the wild-type DmAChE was evaluated by the equation ... codes 1DX4 and 1QO9). One of these conformations results in the formation of a chan- nel approximately 5 A ˚ in diameter, connecting the gorge to the bulk solven...

Ngày tải lên: 07/03/2014, 05:20