Báo cáo khoa học: Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons ppt

... Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregu- lin beta1 in the Golgi apparatus: fluorescence correla- tion spectroscopic observation of the dynamics of ectodomain shedding in living ... Heitzman D, Stahl RC, DiPino Jr F & Carey DJ (2006) Neuregulin isoforms in dorsal root ganglion neurons: effects of the cytoplasmic domain on localization and membrane sh...

Ngày tải lên: 16/03/2014, 04:20

... presence of P i in the incubation medium [6–8]. Furthermore, the accelerating effects of these cyanine dyes on the mitochondrial oxygen consumption were attributable mainly to the induction of the ... consump- tion [6–8]. These actions of cyanine dyes were attributable mainly to the results of induction of the mitochondrial PT [9,10]. Thus, acceleration of mitochondrial ox...

Ngày tải lên: 16/03/2014, 18:20

... acetylation of Ets1 are also unknown, but of future interest, as mutation of the Ets binding motif (m4) results in both a loss of protein binding and the TSA superinduction of Timp-1. Eleven NAD-independent ... effect on basal expression of Timp-1, only on induced gene expression. In conclusion, this is to our knowledge, the only described instance of HDAC inhibitors hav...

Ngày tải lên: 16/03/2014, 18:20

... consequent effects on interactions involving R98. Modeling studies indicated that insertion of a Trp res- idue at position 74 in the PfTIM structure results in severe short contacts with neighboring ... to in uence the precise positioning of the functional groups involved in catalysis, resulting in a significant reduction of k cat values in the case of the Y74W* TIM muta...

Ngày tải lên: 18/02/2014, 11:20

... The bactericidal effects of H4-(86–100) and ciprofloxacin were completed within 30 min, as incubation of the cells for a longer period (2 h) in the presence of increasing concentrations of the compounds ... His- tone H4 contains two a-helical regions. One region spans amino acids 55–67 [32]. A second region, that spans amino acids 70–90, has been demonstrated to adopt the a-helical...

Ngày tải lên: 18/02/2014, 14:20

... processes including proliferation, apopto- sis, differentiation, and so on. Isoforms of numerous proteins have been studied and compared in this man- ner, including alternative isoforms of members of ... disparities in their expression levels at the onset of foci formation. As such, we generated several expression constructs for Mxi1-SRa containing different lengths of 5¢-UTR,...

Ngày tải lên: 18/02/2014, 16:20

... 3171 Inhibitory effects of nontoxic protein volvatoxin A1 on pore-forming cardiotoxic protein volvatoxin A2 by interaction with amphipathic a-helix Pei-Tzu Wu 1 , Su-Chang Lin 2 , Chyong-Ing Hsu 1 , ... 1–4), which may imply that one molecule of VVA2 has one binding site for interacting with either VVA1 or VVA2. Additional investigation of the characteristics of binding of VVA2...

Ngày tải lên: 19/02/2014, 06:20

... of the point of growth inhibition of UY211 (D 420 ¼ 0.60). The point of growth inhibition of GRd.tsf when expressed as a percentage of that of UY211, was independent of the initial proline concentra- tion ... that the concentrations of ligands were maintained at a constant level during migration of the elongation factors, thereby favouring equilibrium conditions. The conce...

Ngày tải lên: 21/02/2014, 00:20

... repression of COX/PGES activity was clearly antagonized by increasing the concentration of RU486. However, in marked contrast, RU486 primarily resulted in an increased overall inhibition of the response curves ... levels of prostaglandins [4]. Conversely, COX-2 expression is highly sensitive to glucocorticoid inhibition, suggesting that inhibition of COX-2 is critical in t he...

Ngày tải lên: 07/03/2014, 16:20

... than control pcDNA–HEK293 cells. Nontoxic concentra- tions of each polyphenol were used in combination with increasing concentrations of etoposide to deter- mine the effects of the polyphenols on ... activity. Effects of quercetin and silymarin on photoaffinity labelling of MRP1 and MRP4 with [ 32 P] 8-azidoATP[aP] To determine whether silymarin and quercetin bind to nucl...

Ngày tải lên: 07/03/2014, 21:20