Báo cáo khoa học: Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons ppt

Báo cáo khoa học: The effects of a-secretase ADAM10 on the proteolysis of neuregulin-1 pot

... Meltrin beta(ADAM19) mediates ectodomain shedding of Neuregu-lin beta1 in the Golgi apparatus: ﬂuorescence correla-tion spectroscopic observation of the dynamics of ectodomain shedding in living ... Heitzman D, Stahl RC, DiPino JrF & Carey DJ (2006) Neuregulin isoforms in dorsalroot ganglion neurons: effects of the cytoplasmicdomain on localization and membrane shedding of Nrg-1 type I. J ... inhibition of neuregulin-1 processing in human astroglioma cell line U373; however,speciﬁc RNA interference-induced knockdown of ADAM10 remainedwithout effect. In vivo investigations of mice overexpressing...

Báo cáo khoa học: Multiple effects of DiS-C3(5) on mitochondrial structure and function pot

... presence of Pi in the incubationmedium [6–8]. Furthermore, the accelerating effects of thesecyanine dyes on the mitochondrial oxygen consumptionwere attributable mainly to the induction of the ... consump-tion [6–8]. These actions of cyanine dyes were attributablemainly to the results of induction of the mitochondrial PT[9,10]. Thus, acceleration of mitochondrial oxygen con-sumption ... analysis of mitochondrial conﬁguration bytransmission electron microscopy revealed that the a cceler-ating eﬀect of DiS-C3(5) on mitochondrial oxygen con-sumption reﬂects t he induction of the...

Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx

... acetylation of Ets1 are also unknown, but of future interest, as mutation of the Ets binding motif(m4) results in both a loss of protein binding and theTSA superinduction of Timp-1.Eleven NAD-independent ... effect on basal expression of Timp-1, only on induced gene expression. In conclusion, this is to our knowledge, the onlydescribed instance of HDAC inhibitors having oppos-ite effects on the ... (2003) Inhibi-tion of MMTV transcription by HDAC inhibitorsoccurs independent of changes in chromatin remodel-ing and increased histone acetylation. Oncogene 22,4807–4818.32 Thomson S, Clayton...

Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

... consequent effects on interactions involving R98.Modeling studies indicated that insertion of a Trp res-idue at position 74 in the PfTIM structure results in severe short contacts with neighboring ... to in uence the precise positioning of the functional groupsinvolved in catalysis, resulting in a signiﬁcant reduction of kcatvalues in the case of the Y74W* TIM mutant,even at concentrations ... a distribution of partiallyunfolded conformations. At a protein concentration of 5 lm, the monomeric species appears to predominate in the case of Y74W*. The gel ﬁltration results indicatethat...

Tài liệu Báo cáo khoa học: Antimicrobial effects of H4-(86–100), histogranin and related compounds – possible involvement of DNA gyrase ppt

... Thebactericidal effects of H4-(86–100) and ciproﬂoxacinwere completed within 30 min, as incubation of thecells for a longer period (2 h) in the presence of increasing concentrations of the compounds ... His-tone H4 contains two a-helical regions. One regionspans amino acids 55–67 [32]. A second region, thatspans amino acids 70–90, has been demonstrated toadopt the a-helical conformation when ... membraneand binding to the DNA without inducing cell lysis. In the present study, HNr and H4-(86–100), like thequinolone antibiotic ciproﬂoxacin, displayed rapid(within 30 min; Fig. 4) inhibition of...

Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt

... processes including proliferation, apopto-sis, differentiation, and so on. Isoforms of numerousproteins have been studied and compared in this man-ner, including alternative isoforms of members of ... disparities in theirexpression levels at the onset of foci formation. Assuch, we generated several expression constructs forMxi1-SRa containing different lengths of 5¢-UTR, andtested these in in vitro ... Evolutionaryrelationships and functional conservation among verte-brate Max-associated proteins: the zebra ﬁsh homolog of Mxi1. Oncogene 9, 3167–3177.C. Dugast-Darzacq et al. Distinct functions of...

Tài liệu Báo cáo khoa học: Inhibitory effects of nontoxic protein volvatoxin A1 on pore-forming cardiotoxic protein volvatoxin A2 by interaction with amphipathic a-helix doc

... 3171Inhibitory effects of nontoxic protein volvatoxin A1 on pore-forming cardiotoxic protein volvatoxin A2by interaction with amphipathic a-helixPei-Tzu Wu1, Su-Chang Lin2, Chyong-Ing Hsu1, ... 1–4), which may imply thatone molecule of VVA2 has one binding site forinteracting with either VVA1 or VVA2. Additionalinvestigation of the characteristics of binding of VVA2to VVA1 will be ... Additionally, VVA2 bindsliposome-containing membranes, as demonstrated bythe exclusive presence of VVA2 in the pellet fraction(Fig. 1B, lanes 5 and 6). Intriguingly, the presence of VVA1 inhibited...

Tài liệu Báo cáo khoa học: Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts pptx

... of the point of growthinhibition of UY211 (D420¼ 0.60). The point of growthinhibition of GRd.tsf when expressed as a percentage of that of UY211, was independent of the initial proline concentra-tion ... that the concentrations of ligandswere maintained at a constant level during migration of the elongation factors, thereby favouring equilibriumconditions. The concentration of guanine nucleotidesrequired ... level of pppGpp in UY211 before starvation was given a value of 1.0. Thedependency of growth inhibition on proline concentrationwas determined by growing cells in glucose/Mops containingdifferent...

Báo cáo khoa học: Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release docx

... repression of COX/PGES activitywas clearly antagonized by increasing the concentration of RU486. However, in marked contrast, RU486 primarilyresulted in an increased overall inhibition of the responsecurves ... levels of prostaglandins [4]. Conversely, COX-2 expression is highlysensitive to glucocorticoid inhibition, suggesting thatinhibition of COX-2 is critical in t he repression of prostaglandins ... expression (Figs 1 and 2 ). In ad dition, the ability of RU486 to antagonize the repressive effects of 0.1 lMdexamethasone or budesonide was examined. In each case,a concentration-dependent antagonism...

Báo cáo khoa học: Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5) potx

... thancontrol pcDNA–HEK293 cells. Nontoxic concentra-tions of each polyphenol were used in combinationwith increasing concentrations of etoposide to deter-mine the effects of the polyphenols on ... activity. Effects of quercetin and silymarin on photoafﬁnity labelling of MRP1 and MRP4with [32P] 8-azidoATP[aP]To determine whether silymarin and quercetin bind tonucleotide (ATP)-binding sites on ... 1-chloro-2, 4-dinitro-benzene (cDNB), creatine phosphokinase, creatine kinase,cGMP, doxorubicin, quercetin, silymarin, hesperetin, daidz-ein, resveratrol, naringenin, GSH and GST were allobtained from...

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