Báo cáo khoa học: Refined solution structure and backbone dynamics of the archaeal MC1 protein ppt

... inwards, the arms close and the tips of the arms wrap around the DNA. The amplitudes and time scales of the intramolecular motions experienced by the protein backbone are com- monly determined from the 15 N-NMR ... Superimposition of the 15 low- est-energy structures fitted on the second- ary structure elements. (B) Ribbon diagram of the lowest-energy s...

Ngày tải lên: 22/03/2014, 17:20

... further our knowledge with respect to the mechanisms of action of these proteins, it is crucial that we define the precise boundaries of the STI1-homologous domain and compare the struc- tures of ... phosphoprotein STI1. We determined the solution structure of a protein fragment containing amino acids 275–342 of hHR23B (termed XPCB–hHR23B) and compared it with...

Ngày tải lên: 07/03/2014, 17:20

... use the following categories of features: 1. ( ) 2. ( ) and 3. ( ) and 4. ( ) and 5. ( ) and 6. ( ) and 7. ( ) and 8. ( ) and 9. ( ) and Category 1 features depend only on the source word and the ... “which”, in the first example the German word “die”, the word “das” in the second and the word “was” in the third. The considered English and German con...

Ngày tải lên: 20/02/2014, 18:20

... primers and the T3 vector primer. The sequences were obtained after the cloning of the PCR products into the pCR4-TOPO TA vector (Invitrogen). Protein structure modeling Homology models of the S. ... against the hemocyanin fraction show staining of the two 75 kDa bands in Western blot, but do not recognize any other proteins of the hemolymph. Although we expect...

Ngày tải lên: 20/02/2014, 11:20

... mice [28]. The instability of DA at the neutral pH of the cytosol causes the forma- tion of toxic aminochromes, and these species are not formed when DA is protonated at the acidic pH of the storage ... additional risk of oxidative stress, as DA can auto-oxidize at the neutral pH of the cytosol and thereby form toxic DA-quinone species, superoxide radicals and...

Ngày tải lên: 14/02/2014, 21:20

... within the brain. Further studies are required to determine the function of GIF within the normal, injured and neurodegenerative brain, and to establish the therapeutic potential of the protein. Acknowledgements This ... neurodegenerative disease. Synthesis and secretion of GIF in the brain Cellular and temporal localization of GIF synthesis Whilst the MT1 and...

Ngày tải lên: 16/02/2014, 15:20

... form protru- sions at the entrance of the cleft, and the distance between Nf of Lys229 and Oe1 of Glu361 is 16.7 A ˚ . On the other hand, the width of the sugar-binding cleft of EcoMBP is apparently ... suggest that the structure of the N-domain part and the capacity of the sugar-binding site are critical in determining the specificity of the bac...

Ngày tải lên: 19/02/2014, 00:20

... (Met1)-ONC (M23L) by the addition of AAP, as described in the Materials and methods. Completion of the hydrolysis was confirmed by the disappearance of the (Met1)-ONC (M23L) signal in the MALDI-TOF mass spectra ... analyzed by MALDI-TOF MS. The addition of the protease is considered the zero time point. The relative intensities of the peaks from the mass spe...

Ngày tải lên: 19/02/2014, 12:20

... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 746–754, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP What lies beneath: Semantic and syntactic ... in the example) between the abandoned thought and its replacement, 2. Determination that the abandoned portion contains unique and preservable content and should...

Ngày tải lên: 20/02/2014, 07:20

... purpose of utteranc- es and their domain context, it is then possible to correct some of the insertion and mis-recognised word errors from the SR and determine the com- municative intent of the ... modified the grammar they use to change all the rules of the form A -> B C to the form A -> B Link C, and add con- straints to the rules application i...

Ngày tải lên: 20/02/2014, 21:20