Báo cáo khoa học: The role of DYRK1A in neurodegenerative diseases docx

... aggregation into NFTs and the several-fold increase in the number of DYRK1A- positive NFTs. Phosphorylation of ASF by nuclear DYRK1A increases the level of 3R-tau, leading to an imbalance in the 3R ... speckles, the site of storage of inactivated serine⁄ arginine-rich pro- teins, including ASF. This mechanism prevents ASF from facilitating tau exon 10 inclusion and...

Ngày tải lên: 22/03/2014, 16:21

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs, thereby releasing the nucleocapsid into the lumen of these vesi- cles. Then, the capsid uses these intra-endosomal ... mild developmental delay. The protein defective in this disorder is also a NHEJ protein. The distinct clinical features of the patients will be discussed in the con...

Ngày tải lên: 19/02/2014, 07:20

... focus and determines how the focus moves according to the signals which the speaker uses in discourse to indicate the movement. Given a process notion of focus, the paper reviews the difficulties ... by means of rules for antecedence. I. The focus provides a source of antecedence in rules for interpreting pronominal anaphora. 2. Focussing provides a control fo...

Ngày tải lên: 21/02/2014, 20:20

... equal sharing of initiative — the expert had ini- tiative for 60% of the turns in finance ADs and 51% of the turns in software ADs. This is because in the ADs, the novice must communicate the de- tails ... learning (i.e., task success for the tutor). Surpris- ingly, students had initiative more of the time in the didactic dialogues (21% of the turns) tha...

Ngày tải lên: 22/02/2014, 02:20

... pairs found in the four histones may negatively regulate the binding of chromodomains to methylated lysines. Indeed, chromo- domain-containing proteins are involved in a variety of functions, ... divergence in chromatin remodelling. One of the most distinctive characteristics of chromatin remodelling during spermatogenesis is the expression of a large number of histo...

Ngày tải lên: 07/03/2014, 16:20

... equivalent in nin- hydrin colour to 1.0 l mol of leucine in 5 h at pH 7.4 at 37 °C in the presence of CaCl 2 . Data are expressed as the mean ± SD of three independent experiments. (C) The ratio of hydrolytic ... combined thermodynamic and crystallographic study of trypsin and thrombin inhibition. J Mol Biol 313, 593–614. 33 Blevins RA & Tulinsky A (1985) The refine...

Ngày tải lên: 16/03/2014, 00:20

... doubling rules in the inflection of English verbs C. The determination of word-breaking rules as used in end -of -the- line practices in type composition D. The determination of parts -of- speech ... it convenient to group the words of written English into a linear ordering according to the number of vowel strings contained in the word. Our study of the o...

Ngày tải lên: 19/02/2014, 19:20

... is the indeterminacy which arises from the mapping of a continuous territory onto a chart with a finite resolving power; it is not the result of an intrinsically indeterminate use of a discrete ... urgently in MT, be- cause of the great bulk of the material to be stored, but the mathematical problems it pre- sents are the same as in other fields, except where,...

Ngày tải lên: 07/03/2014, 18:20

... through the exchange between subunits of either their N-ter- minal, or their C-terminal ends [33–35]. We found that the behavior with the model membrane of the dimer in which the C-terminal ends ... ‘r’) and variation of the inclination (inclination angle ‘i’) with respect to the plane of the membrane (parallel to the xy plane). Cter and Nter are the C-terminal a...

Ngày tải lên: 19/02/2014, 06:20

... likely that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible. From ... as a nother identification of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex II and against...

Ngày tải lên: 19/02/2014, 16:20